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张晓兵

发布于:2018-01-19 星期五 19:49:56 点击数:18330

张晓兵,教授,博士生导师

长江学者特聘教授

国家杰出青年科学基金获得者

核酸适配体湖南省工程实验室主任

Tel: +86-731-88821894

E-mail: xbzhang@hnu.edu.cn xiaobingzhang89@hotmail.com


基本信息

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教育背景

1989-1993 湖南大学 有机化工 学士;

1995-1998 湖南大学 有机化学 硕士;

1998-2001 湖南大学 分析化学 博士。

工作履历

2001年获分析化学博士学位后留校任教。2003-2005年在法国里昂高等师范学校、瑞典皇家工学院从事生物有机化学方向博士后研究,20053月加入湖南大学化学生物传感与计量学国家重点实验室,2006年起任湖南大学教授。分别于20086-9月以邀请教授的身份到法国里昂高等师范学校,20092-8月以高级访问学者的身份到美国伊利诺伊大学香槟分校从事生物分析领域的科研合作。

学术兼职

现任《分析化学》及《中国科学-化学》编委。

研究领域

新型有机小分子荧光探针的设计与合成;荧光生物探针在生物分析中的应用。

科研项目

主持国家杰出青年科学基金项目,国家自然科学基金面上项目以及国家“973”计划课题等

学术成果

代表性论文:

1. H. Liu, K. Li, X.-X. Hu, L. Zhu, Q. Rong, Y. Liu, X.-B. Zhang*, J. Hasserodt, F.-L. Qu, W. Tan, In situ localization of enzyme activity in live cells by a molecular probe releasing a precipitating fluorochrome, Angew. Chem. Int. Ed. 2017, 56, 11788-11792. 

2. Y. Wu, L. Zhang, C. Cui, S. Cansiz, H. Liang, C. Wu, I.-T. Teng, W. Chen, Y. Liu, W. Hou, X.-B. Zhang*, W. Tan*, Enhanced targeted gene transduction: AAV2 vectors conjugated to multiple aptamers via reducible disulfide linkages, J. Am. Chem. Soc. 2018, 140, 2-5.

3. Hong-Min Meng, Hui Liu, Hailan Kuai, Ruizi Peng, Liuting Mo and Xiao-Bing Zhang*, Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy, Chem. Soc. Rev., 2016, 45, 2583-2602.

4. Huanhuan Fan, Guobei Yan, Zilong Zhao, Xiaoxiao Hu, Wenhan Zhang, Hui Liu, Xiaoyi Fu, Ting Fu, Xiao-Bing Zhang* and Weihong Tan*, A Smart Photosensitizer-MnO2 Nanosystem for Enhanced Photodynamic Therapy via Reducing Glutathione Levels in Cancer Cells, Angew. Chem. Int. Ed., 2016, 55, 5477-5482.

5. Yifan Lv, Rong Hu, Guizhi Zhu, Xiao-Bing Zhang*, Lei Mei, Qiaoling Liu, Liping Qiu, Cuichen Wu, Weihong Tan*, Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers, Nature Protocols, 2015, 10, 1508-1524.

6. Zhi-Ling Song, Zhuo Chen*, Xia Bian, Li-Yi Zhou, Ding Ding, Hao Liang, Yu-Xiu Zou, Shan-Shan Wang, Long Chen, Chao Yang, Xiao-Bing Zhang*, and Weihong Tan*, Alkyne-Functionalized Superstable Graphitic Silver Nanoparticles for Raman Imaging, J. Am. Chem. Soc., 2014, 136, 13558-13561.

7. Hao Liang, Xiao-Bing Zhang*, Yifan Lv, Liang Gong, Ruowen Wang, Xiaoyan Zhu,Ronghua Yang* and Weihong Tan*. Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy, Acc. Chem. Res., 2014, 47, 1891-1901.

8. Zilong Zhao, Hongmin Meng, Nannan Wang, Michael J. Donovan, Ting Fu, Mingxu You, Xiao-Bing Zhang*, Weihong Tan*, A Controlled-release Nanocarrier with pHe-driven Targeting and Translocation for Drug Delivery, Angew. Chem. Int. Ed., 2013, 52, 7487-7491.

9. Tao Chen, Cuichen Sam Wu, Elizabeth Jimenez, Zhi Zhu, Joshua G. Dajac, Mingxu You, Da Han, Xiao-Bing Zhang*, and Weihong Tan*, DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy, Angew. Chem. Int. Ed., 2013, 52, 2012-2016.

10. Cuichen Wu, Da Han, Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiaobing Zhang*, Weihong Tan*, Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. J. Am. Chem. Soc., 2013, 135, 18644-18650.

11. Mingxu You, Yan Chen, Xiao-Bing Zhang*, Haipeng Liu, Ruowen Wang, Kelong Wang, KathrynR.Williams, and Weihong Tan*, An Autonomous and Controllable Light-Driven DNA Walking Device. Angew. Chem. Int. Ed., 2012, 51, 2457-2460.

12. Tao Chen, Ismail Oecsoy, Quan Yuan, Ruowen Wang, Mingxu You, Zilong Zhao, Erqun Song, Xiao-Bing Zhang*, Weihong Tan,* One-Step Facile Surface Engineering of Hydrophobic Nanocrystals with Designer Molecular Recognition, J. Am. Chem. Soc., 2012, 134, 13164-13167.

13. Liu Yang, Ling Meng, Xiao-Bing Zhang*, Yan Chen, Guizhi Zhu, Haipeng Liu, Kwame Sefah and Weihong Tan*, Engineering Polymeric Aptamers for Selective Cytotoxicity. J. Am. Chem. Soc., 2011, 133, 13380-13386.

14. Li-Min Lu, Xiao-Bing Zhang*, Rong-Mei Kong, Bin Yang, Weihong Tan*, Ligation-triggered DNAzyme Cascade for Amplified Fluorescence Detection of Biological Small Molecules with Zero-Background Signal. J. Am. Chem. Soc., 2011, 133, 11686-11691.


奖励与荣誉

2007年入选教育部新世纪优秀人才计划项目,

2011年获湖南省杰出青年科学基金资助,

2013年获国家杰出青年科学基金资助,

2015年入选湖南省芙蓉学者特聘教授, 

2016年入选湖南省科技领军人才、国家中青年科技创新领军人才、教育部长江学者特聘教授,

2017年入选国家“万人计划”科技创新领军人才、国家百千万人才工程,并被授予“有突出贡献中青年专家称号”