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聂舟

发布于:2018-01-04 星期四 14:15:55 点击数:17364

教授,博士生导师

国家杰出青年基金获得者,教育部青年长江学者,万人计划青年拔尖人才

生物大分子化学生物学湖南省重点实验室主任

Tel: 0731-88821626

Email: niezhou@hnu.edu.cn / niezhou.hnu@gmail.com


基本信息

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教育背景

1998-2002  南开大学生命科学学院 理学学士

2002-2007  中国科学院化学研究所 理学博士


工作履历

2015-至今  湖南大学化学化工学院 副院长

2011-2012 Purdue University(普渡大学)  博士后

2011-至今  湖南大学化学化工学院 教授 博士生导师

2008-2010 湖南大学化学化工学院 副教授

2007-2008 湖南大学化学化工学院 讲师

学术兼职

2018年10月-至今 中国化学会青年化学工作者委员会委员

2018年6月-至今 中国化学会期刊《分析化学》编委

2015年7月-至今 英国皇家化学会所属学术期刊《RSC Advances》Associate Editor

研究领域

围绕生物医学中关键机制,如表观遗传及细胞信号传导等开展深入探索,主要开展以下两方面研究:

1. 基于功能蛋白质和核酸的生物传感新方法;

2. 化学手段调控细胞行为和命运。

科研项目

国家自然科学基金杰出青年基金

国家自然科学基金优秀青年基金

国家自然科学基金委创新研究群体基金项目(主要成员)

国家自然科学基金面上项目2项

国家自然科学基金青年基金

湖南省杰出青年基金

学术成果

自2009年以来作为通讯作者在J. Am. Chem. Soc.Angew. Chem. Int. Ed., Nano Lett., Nucleic Acids Res., Chem. Sci., TrAC-Trend. Anal. Chem., Anal. Chem., Small, Chem. Commun., 等SCI收录源刊物上发表SCI论文70余篇(影响因子> 5,60余篇),近五年论文他引2000多次。获国家发明专利授权2项,受邀为Springer出版社撰写英文学术专著2章。

Selected publications:

  1. X.Y. Luo#, B.B. Xue#, G.F. Feng#, J.H. Zhang, B. Lin, P. Zeng, H.Y. Li, H.B. Yi, X.-L. Zhang, H.Z. Zhu*, Z. Nie*. Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection. J. Am. Chem. Soc., 2019, 141, 5182-5191

  2. G.F. Feng#, X.Y. Luo#, X. Lu, S.Y. Xie, L. Deng, W.Y. Kang, F. He, J.H. Zhang, C.Y. Lei*, B, Lin, Y. Huang, Z. Nie*, S.Z. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment. Angew. Chem. Int. Ed., 2019, 58, 6590-6594. (Very Important Paper, Back Cover)

  3. M. Wang, F. He, H. Li, S.H. Yang, J.H. Zhang, P. Ghosh, H.-H. Wang*, Z. Nie*. A near-infrared light-activated DNA-agonist nanodevice for nongenetically and remotely controlled cellular signaling and behaviors in live animals. Nano Lett., 2019, 19, 2603-2613.

  4. H. Li, M. Wang, T.H. Shi, S.H. Yang, J.H. Zhang, H.-H. Wang*, Z. Nie*. A DNA-mediated chemically induced dimerization (D-CID) nanodevice for nongenetic engineering of receptor to control cell behaviorAngew. Chem. Int. Ed., 2018, 57,10226-10230. (Hot paper)

  5. Y. Li, S.J. Sun, L. Fan, S.F. Hu, Y. Huang, K. Zhang, Z. Nie*, S.Z. Yao. Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis. Angew. Chem. Int. Ed., 2017, 56, 14888-14892.

  6. Z. Nie*, P.F. Wang, C. Tian, C.D. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405.

  7. C.Y. Lei, Y. Huang, Z. Nie*, J. Hu, L.J. Li, G.Y. Lu, Y.T. Han, S.Z. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362. (Hot Paper)

  8. G.F. Feng, C. Luo, H.B. Yi, L. Yuan, B. Lin, X.Y. Luo, X.X. Hu, H.-H. Wang, C.Y. Lei, Z. Nie*, S.Z. Yao. DNA mimics of red fluorescent proteins (RFP) based on G-quadruplex-confined synthetic RFP chromophores. Nucleic Acids Res., 2017, 45, 10380-10392.

  9. W. Li, Y. Li, Z.L. Liu, B. Lin, H.B. Yi, F. Xu, Z. Nie*, S.Z. Yao. Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity. Nucleic Acids Res., 2016, 44, 7373-7384.

  10.  K.Y. He, Y. Li, B.B. Xiang, P. Zhao, Y.F. Hu, Y. Huang, W. Li, Z. Nie*, S.Z. Yao. A universal platform for building molecular logic circuits based on a reconfigurable three-dimensional DNA nanostructure. Chem. Sci., 2015, 6, 3556-3564.

  11. S.F. Hu, J.H. Zhang, R. Tang, J.H. Fan, H.Q. Liu, W.Y. Kang, C.Y. Lei,  Z. Nie*, Y. Huang*, S.Z. Yao. Click-type protein−DNA conjugation for Mn2+ imaging in living cells. Anal. Chem., 2019, 91, 10180-10187.

  12. S. Wang, W. Song, S. Wei, S. Zeng, S. Yang, C. Lei*, Y. Huang, Z. Nie*, S. Yao. Functional titanium carbide MXenes-loaded entropy-driven RNA explorer for long noncoding RNA PCA3 imaging in live cells. Anal. Chem., 2019, 91, 86228629.

  13. S. Wang, S.H. Wei, S.G. Wang, X.H. Zhu, C. Lei*, Y. Huang, Z. Nie*, S.Z. Yao. Chimeric DNA-functionalized titanium carbide MXenes for simultaneous mapping of dual cancer biomarkers in living cells. Anal. Chem., 2019, 91, 1651-1658.

  14. S.J. Sun, Y.N. Liu, J.L. Xia, M. Miao, R. Tang, C.Y. Lei, Y. Huang, Z. Nie*, S.Z. Yao. A semisynthetic fluorescent protein assembly-based FRET probe for real-time profiling of cell membrane protease functions in situ. Chem. Commun., 2019, 55, 2218-2221.

  15. S. Zeng, D. Liu, C.Y. Li, F. Yu, L. Fan, C.Y. Lei, Y. Huang*, Z. Nie*, S.Z. Yao. Cell-surface-anchored ratiometric DNA tweezer for real-time monitoring of extracellular and apoplastic pH. Anal. Chem., 2018, 90, 13459-13466.

  16. J.K. Wang, Y.L. Zhu, C.A. Grimes, Z. Nie*, Q.Y. Cai*. Eu,Sm,Mn-doped CaS nanoparticles with 59.3% upconversion-luminescence quantum yield: enabling ultrasensitive and facile smartphone-based sulfite detectionAnal. Chem., 2018, 90, 8658–8664.

  17. S.F. Hu, X.Y. Chen, C.Y. Lei, R. Tang, W.Y. Kang, H.H. Deng, Y. Huang*, Z. Nie*, S.Z. Yao. Charge designable and tunable GFP as a target pH-responsive carrier for intracellular functional protein delivery and tracing. Chem. Commun., 2018, 54, 7806-7809.

  18. X.H. Zhu, L. Fan, S.G. Wang, C.Y. Lei*, Y. Huang, Z. Nie*, S.Z. Yao. Phospholipid-tailored titanium carbide nanosheets as a novel fluorescent nanoprobe for activity assay and imaging of phospholipase D. Anal. Chem., 2018, 90, 6742-6748.

  19. J. Zhang, M.L. Wang, R. Tang, Y.N. Liu, C.Y. Lei, Y. Huang*, Z. Nie*, S.Z. Yao. Transpeptidation-mediated assembly of tripartite split green fluorescent protein for label-free assay of sortase activity. Anal. Chem., 2018, 90, 3245-3252.

  20. J.K. Wang, N. He, Y.L. Zhu, Z.B. An, P. Chen, C.A. Grimes, Z.Nie*, Q.Y. Cai*. Highly-luminescent Eu,Sm,Mn-doped CaS up/down conversion nano-particles: application to ultra-sensitive latent fingerprint detection and in vivo bioimaging. Chem. Commun., 2018, 54, 591-594.

  21. K.L. Zhao, Y. Tang, Z. Wang, J. Zhang, C.Y. Lei, H.-H. Wang, H. Li, Y. Huang*, Z. Nie*, S.Z. Yao. Surface charge tuneable fluorescent protein-based logic gates for smart delivery of nucleic acids. Chem. Commun., 2017, 53, 11326-11329.

  22. Z.L. Liu, X.Y. Luo, Z. Li, Y. Huang, Z. Nie*, H.-H. Wang*, S.Z. Yao. Enzyme-activated G-quadruplex synthesis for in situ label-free detection and bioimaging of cell apoptosis. Anal. Chem., 2017, 89, 1892-1899.

  23. X.H. Zhu, M. J.Liu, Y. Liu, R.W. Chen, Z.Nie*, J.H. Li*, S.Z. Yao. Carbon-coated hollow mesoporous FeP microcubes: an efficient and stable electrocatalyst for hydrogen evolution. J. Mater. Chem. A, 2016, 4, 8974-8977.

  24. Y. Li, P. Li, R. Zhu, C. Luo, H. Li, S.F. Hu, Z. Nie*, Y. Huang, S.Z. Yao. Multifunctional gold nanoclusters-based nanosurface energy transfer probe for real-time monitoring of cell apoptosis and self-evaluating of pro-apoptotic theranostics. Anal. Chem., 2016, 88, 11184-11192.

  25.  Y.T. Han, P. Li, Y.T. Xu, H. Li, Z.L. Song, Z. Nie*, Z. Chen*, S.Z. Yao. Fluorescent nanosensor for probing histone acetyltransferase activity based on acetylation protection and magnetic graphitic nanocapsules, Small, 2015, 11, 877-885.

  26. P. Zhao, K.Y. He, Y.T. Han, Z. Zhang, M.Z. Yu, H.H. Wang, Y. Huang, Z. Nie*, S.Z. Yao. Near-infrared dual-emission quantum dots-gold nanoclusters nanohybrid via co-template synthesis for ratiometric fluorescent detection and bioimaging of ascorbic acid in vitro and in vivo. Anal. Chem., 2015, 87, 9998-10005.

  27. Y.T. Han, H. Li, Y.F. Hu, P. Li, H.X. Wang, Z. Nie*, S.Z. Yao. Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III) probes. Anal. Chem., 2015, 87, 9179-9185.

  28. C. Yin, M. Wang, C.Y. Lei, Z. Wang, P. Li, Y. Li, W. Li, Y. Huang*, Z. Nie*, S.Z. Yao. Phosphorylation-mediated assembly of a semisynthetic fluorescent protein for label-free detection of protein kinase activity. Anal. Chem., 2015, 87, 6311-6318.

  29. S.Y. Chen, Y. Li, Y.F. Hu, Y.T. Han, Y. Huang, Z. Nie*, S.Z. Yao. Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of Histone Acetyltransferases, Chem. Commun., 2015, 51, 4469-4472.

  30. Y.F. Hu, S.Y. Chen, Y.T. Han, H.J. Chen, Q. Wang, Z. Nie*, Y. Huang, S.Z. Yao. Unique electrocatalytic activity of a nucleic acid-mimicking coordination polymer for the sensitive detection of coenzyme A and histone acetyltransferase activity. Chem. Commun., 2015, 51, 17611-17614.

  31. S. Tang, Z. Nie*, W. Li*, D.Q. Li, Y. Huang, S.Z. Yao. A poly(ADP-ribose) polymerase-1 activity assay based on the FRET between a cationic conjugated polymer and supercharged green fluorescent protein. Chem. Commun., 2015, 51, 14389-14392.

  32. Z. Wang, Y. Li, L.J. Li, D.Q. Li, Y. Huang*, Z. Nie*, S.Z. Yao. DNA-mediated supercharged fluorescent protein/graphene oxide interaction for label-free fluorescence assay of base excision repair enzyme activity. Chem. Commun., 2015, 51, 13373-13376.

  33. X. Liu, Y. Li, X.H. Xu, P. Li, Z. Nie*, Y. Huang, S.Z. Yao*. Nanomaterial-based tools for protein kinase bioanalysis. TrAC-Trend. Anal. Chem., 2014, 58, 40-53. (Invited Review)

  34. Z.L. Liu, W. Li, Z. Nie*, F.F. Peng, Y. Huang, S.Z. Yao. Randomly arrayed G-quadruplexes for label-free and real-time assay of enzyme activity. Chem. Commun., 2014, 50, 6875-6878.

奖励与荣誉

2016年 教育部“长江学者”青年学者

            中国化学会青年化学奖

2015年 中组部“万人计划”青年拔尖人才

            卢嘉锡优秀导师奖

2013年 湖湘青年科技创新创业平台培养对象

2010年 教育部新世纪人才


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