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袁林

发布于:2018-01-04 星期四 15:01:14 点击数:12356

教授,博士生导师

国家优秀青年科学基金获得者

E-mail: lyuan@hnu.edu.cn

Tel: 0731-88821632




基本信息

袁林照片.jpg

袁林,19825月出生,现为湖南大学化学化工学院、化学生物传感与计量学国家重点实验室教授、博士生导师。分别于南华大学和湖南大学获得学士和博士学位,在新加坡国立大学化学系从事博士后研究。2012年至今,历任湖南大学助理教授、副教授、教授。目前已在国际学术期刊上发表论文70余篇,总引用5300余次,h指数为40,其中2012年至今以第一或通讯作者在J. Am. Chem. Soc7篇)、Angew. Chem. Int. Ed6篇)、Chem. Sci.2篇)Anal. Chem.3篇)Adv. Funct. MaterBiomaterials等期刊发表论文30余篇。2016年获国家优秀青年科学基金资助,2017年入选湖南省湖湘青年科技创新英才支持对象。主要从事小分子荧光探针及应用方向的研究。

招生专业:分析化学(化学与生物传感/博士和硕士生)、有机化学(生物有机化学/博士和硕士生)

实验室成员:

博士后:程丹

博士生:任天兵(获2018年国奖)、袁婕、刘晓、李伟、钟维邦、张星星

硕士生:吕芸(获2018年国奖)、文思雨、张维、王志尧、赖焕华、向振、彭蓉

已毕业学生:程丹(博士,获2017年国奖)、潘月(硕士)、魏艳芬(硕士,获2016年国奖)、金芳平(硕士,获2015年国奖)、张倩玲(硕士)




教育背景

2002.9-2006.7  南华大学化学化工学院,工学学士;

2006.9-2008.8  湖南大学化学化工学院,无;

2008.9-2013.5  湖南大学化学化工学院,理学博士.



工作履历

2012. 6-2015. 9  湖南大学化学化工学院,助理教授

2014. 2-2015. 3  新加坡国立大学化学系,博士后

2015. 10-2017. 1  湖南大学化学化工学院,副教授

2017. 1- 现在     湖南大学化学化工学院,教授


学术兼职

《中国化学快报》青年编委;美国化学会会员;J. Am. Chem. SocChem. Sci.Anal. Chem.等期刊审稿人。

研究领域

分子探针及生物成像、有机光功能染料合成及应用

科研项目

国家自然科学基金优秀青年基金(2017-2019)

国家自然科学基金面上项目(2019-2022)

国家自然科学基金重点项目(子课题)(2018-2022)

湖湘青年英才项目(2017-2019)

学术成果

全部文章:http://www.researcherid.com/rid/F-8200-2011

Selected Publications:  *(Corresponding Author)

24. D. Cheng, J. Peng, Y. Lv, D. Su, D. Liu, M. Chen, L. Yuan*X. Zhang. De Novo Design of Chemical Stability Near-infrared Molecular Probes for High-fidelity Hepatotoxicity Evaluation in VivoJ. Am. Chem. Soc. 2019DOI: 10.1021/jacs.9b01374


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23.  L. Su, T. Ren, J. Dong*, L. Liu, S. Xie, L. Yuan*, Y. Zhou*, SF. Yin. Cu (I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties.  J. Am. Chem. Soc. 2019 141 (6), 2535–2544. DOI: 10.1021/jacs.8b12495

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22.  T. Ren, W. Xu, W. Zhang, X. Zhang, Z. Wang, Z. Xiang, L. Yuan*X. Zhang. A General Method to Increase Stokes Shift by Introducing Alternating Vibronic Structures. J. Am. Chem. Soc. 2018140 (24), 7716–7722. DOI: 10.1021/jacs.8b04404

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21. T. Ren, W. Xu, Q. Zhang, X. Zhang, S. Wen, H. Yi, L. Yuan*, X. Zhang. Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network. Angew. Chem. Int. Ed. 2018,  57(25), 7473-7477. DOI:10.1002/anie.201800293


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20. Y. Lv,  D. Cheng,  D. Su,  M.Chen,  B.-C. Yin, L. Yuan*, X. Zhang. Visualization of Oxidative Injury in the Mouse Kidney by Selective Superoxide Anion Fluorescent Probes. Chem. Sci., 20189, 7606-7613. DOI:10.1039/C8SC03308K



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19. T. Ren, Q. Zhang,  D. Su, X. Zhang,  L. Yuan*, X. Zhang. Detection of Analytes in Mitochondria without Interference from Other Sites Based on an Innovative Ratiometric Fluorophore. Chem Sci2018 9, 5461-5466. DOI:10.1039/C8SC01673A    

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18.  D. Cheng, Y. Pan, L. Wang, Z. Zeng, L. Yuan*, X. Zhang, Y.-T. Chang. Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe. J. Am. Chem. Soc. 2017, 139, 285-292. DOI: 10.1021/jacs.6b10508                                              

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17.  J. Peng*, A. Samanta, X. Zeng, S. Han, L. Wang, D. Su, D. T. B. Loong, N.-Y. Kang, S.-J. Park, A. H. All, W. Jiang, L. Yuan*, X. Liu*, Y.-T. Chang*. Real-time in vivo hepatotoxicity monitoring through chromophore-conjugated upconversion nanoprobes. Angew. Chem. Int. Ed2017, 56, 4165 –4169. DOI:10.1002/anie.201612020

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16.  D. Cheng, W. Xu, L. Yuan*, X. Zhang. Investigation of Drug-Induced Hepatotoxicity and Its Remediation Pathway with Reaction-Based Fluorescent Probes. Anal. Chem2017, 89, 7693-7700. DOI: 10.1021/acs.analchem.7b01671

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15.  T. Ren, W. Xu, F. Jin, D. Cheng, L Zhang, L. Yuan*, X. Zhang. Rational Engineering of Bioinspired Anthocyanidin Fluorophores with Excellent Two-Photon Properties for Sensing and Imaging. Anal. Chem2017, 89, 11427-11434. DOI: 10.1021/acs.analchem.7b02538

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14.  W. Xu, Z. Zeng, J.-H. Jiang*, Y.-T.Chang*, L. Yuan*. Discerning the chemistry in individual organelles with small molecule fluorescent probes. Angew. Chem. Int. Ed201655, 13658-13699. DOI:10.1002/anie.201510721

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13.  L. Wang, L. Yuan*, X. Zeng, J. Peng, Y. Ni, J. C. Er, W. Xu, B. K. Agrawalla, D. Su, B. Kim, Y.-T. Chang*. A multisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells. Angew. Chem. Int. Ed201655, 1773-1776. DOI:10.1002/anie.201510003 (commercial available at https://www.sigmaaldrich.com/catalog/product/mm/sct045?lang=zh&region=CN)

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12.  J. Peng, C. L. Teoh, X. Zeng, A. Samanta, L. Wang, W. Xu, D. Su, L. Yuan*, X. Liu, Y.-T. Chang*. Development of a highly selective, sensitive, and fast response upconversion luminescent platform for hydrogen sulfide detection. Adv. Funct. Mater201626, 191-199. DOI:10.1002/adfm.201503715

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11. Y. Wei, D. Cheng, T. Ren, Y. Li, Z. Zeng, L. Yuan*. Design of NIR chromenylium–cyanine fluorophore library for “switch-on” and ratiometric detection of bio-active species in vivoAnal. Chem. 2016, 88, 1842−1849. DOI: 10.1021/acs.analchem.5b04169

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10. L. Yuan, L. Wang, K. Bikram, S.-J. Park, H. Zhu, B. Sivaraman, J. Peng, Q. Xu, Y.-T. Chang. Development of targetable two-photon fluorescent probes to image hypochlorous acid in mitochondria and lysosome in live cell and inflamed mouse model. J. Am. Chem.Soc. 2015, 137, 5930−5938.

9. L. Yuan*, F. Jin, Z. Zeng*, C. Liu, S. Luo, J. Wu. Engineering a FRET strategy to achieve a ratiometric two-photon fluorescence response with a large emission shift and its application to fluorescence imaging. Chem Sci20156, 2360-2365.

8. L. Yuan, W. Lin*, H. Chen, S. Zhu, L. He. A unique family of rigid analogues of the GFP chromophore with tunable two-photon action cross-sections for biological imaging. Angew. Chem. Int. Ed201358, 10018–10022.

7. L. Yuan, W. Lin*, L. Tan, K. Zheng, W. Huang. Lighting up carbon monoxide: fluorescent probes for monitoring CO in living cells. Angew. Chem. Int. Ed201352, 1628–1630.

6. L. Yuan, W. Lin*, K. Zheng, L. He, W. Huang, Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging. Chem. Soc. Rev., 201342, 622-661.

5. L. Yuan, W. Lin*, K. Zheng, S. Zhu, FRET-based small-molecule fluorescent probes: rational design and bioimaging applications. Acc. Chem. Res201346, 1462-1473.

4. L. Yuan, W. Lin, H. Chen, Analogs of Changsha near-infrared dyes with large Stokes Shifts for bioimaging. Biomaterials201334, 9566-9571.

3. L. Yuan, W. Lin*, S. Zhao, W. Gao, B. Chen, L. He, S. Zhu, A unique approach to development of near-infrared fluorescent sensors for in vivo imaging. J. Am. Chem.Soc. 2012134, 13510-13523.

2. L. Yuan, W. Lin,* Y. Xie, B. Chen, S. Zhu. Single fluorescent probe responds to H2O2, NO, and H2O2/NO with three different sets of fluorescence Signals. J. Am. Chem. Soc. 2012, 134, 1305-1315.

1. L. Yuan, W. Lin,* Y. Yang, H. Chen. A unique class of near-infrared functional fluorescent dyes with carboxylic-acid-modulated fluorescence ON/OFF switching: rational design, synthesis, optical properties, theoretical calculations, and applications for fluorescence imaging in living animals. J. Am. Chem. Soc. 2012134, 1200-1211.

 


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奖励与荣誉

2017年  湖湘青年英才

2016年  国家优青