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蒋健晖

发布于:2018-01-18 星期四 19:56:58 点击数:2200

教授,博士生导师

国家杰出青年科学基金获得者(2010),英国皇家化学会会士(FRSC, 2014) ,国家万人计划科技创新领军人才(2017)


基本信息

197110月生于湖南省邵阳市,湖南大学化学化工学院教授,博士生导师。国家杰出青年科学基金获得者(2010),国务院特殊津贴专家(2013),英国皇家化学会会士(FRSC, 2014) ,国家万人计划科技创新领军人才(2017)。曾任《化学学报》、《分析化学》、《Current Analytical Chemistry》、《Analytical ChemistryA-pages等编委。湖南大学分析化学专业学士学位(1993年)、硕士学位(1996年,导师:俞汝勤院士)、理学博士学位(1999年,导师:俞汝勤院士)。日本关西学院大学博士后(2000.11-2001.12,合作导师:Yukihiro Ozaki)、访问教授(2002.11-2003.2)。主要研究方向为生物传感、生物成像和化学生物学SCI收录论文300余篇,他引11,000余次,H指数55。通讯作者论文180余篇,他引6,200余次,H指数42,其中IF>6论文70余篇(Nature Mater 1篇;JACS 6篇;Angew Chem Int Ed 3篇;Chem Rev 1篇;Anal Chem 30篇等)。申请及授权中国发明专利20余件。获2014年国家自然科学二等奖(第三)、2003年国家自然科学二等奖(第五)、2002Buchi国际近红外光谱学奖(排名第一)等。曾主持国家杰出青年科学基金项目、国家重大科学仪器研制项目、欧盟FP7项目等。

教育背景

1996/9 – 1999/6   湖南大学,分析化学,研究生/博士

1993/9 – 1996/6   湖南大学,分析化学,研究生/硕士 

1989/9 – 1993/6   湖南大学,分析化学,本科/学士



工作履历

2017/11 – 至今     湖南大学,校长助理

2011/01 – 至今     湖南大学,化学化工学院 院长

2005/07 – 2012/12  湖南大学,化学化工学院 副院长

2004/12 – 至今     化学生物传感与计量学国家重点实验室,副主任

2003/05 – 至今     湖南大学,教授

2002/11 – 2003/02   日本关西学院大学,访问教授

    2001/03 – 2003/05   湖南大学,副教授

2000/11 – 2001/12   日本关西学院大学,博士后

1999/07 – 2001/03   湖南大学,讲师


研究领域

生物传感、生物成像、化学生物学、化学计量学

科研项目

1.       国家自然科学基金重大科研仪器研制项目,21527810,数字滚环扩增生物分析的单分子成像与计数装置研究,2016/01-2020/12519万元,主持。

2.       国家自然科学基金杰出青年基金项目,21025521,生化分析及生物传感,2011/01-2014/12200万元,主持。

3.       国家自然科学基金面上项目,20875027,基因突变分子传感新方法研究,2009/01-2011/1230万元,主持。

4.       European Commission FP7-HEALTH-2010 Program, 260600, Glycomics by High-throughput Integrated Technologies, 2011/01-2014/067万欧元,主持。

5.       国家科技部国际合作项目,国科外字2011-16-1007,蛋白质糖基化的液相芯片分析新技术研究,2010/12-2013/1253万元,主持。


学术成果

近年部分通讯作者论文

2018: 

1. Jiyun Chen, Xiaomin Xu, Zhimei Huang, Yuan Luo, Lijuan Tang*, Jian-Hui Jiang*, BEAMing LAMP: Single-Molecule Capture and On-bead Isothermal Amplification for Digital Detection of Hepatitis C Virus in Plasma, Chemical Communications, 2018, 54, 291-294.

2.  Hang Zhang, Guanhua Zhang*, Zhiqin Li, Ke Qu, Huimin Shi, Qingfeng Zhang, Huigao Duan, and Jianhui Jiang*, Osiers-sprout-like heteroatoms doped carbon nanofibers as ultra-stable anodes for lithium/sodium ion storage, Nano Research, 2018, 11, in press.

3.  Lan Liu, Jin-Wen Liu, Han Wu, Xiang-Nan Wang, Ru-Qin Yu*, Jian-Hui Jiang*, Branched Hybridization Chain Reaction (bHCR) Circuit for Ultrasensitive Localizable Imaging of mRNA in Living Cells, Analytical Chemistry, 2018, 90, 1502-1505.

4. Jin-Wen Liu, Yu-Min Wang, Chong-Hua Zhang, Lu-Ying Duan, Zheng Li*, Ru-Qin Yu, Jian-Hui Jiang*, Tumor-Targeted Graphitic Carbon Nitride Nanoassembly for Activatable Two-Photon Fluorescence Imaging, Analytical Chemistry, 2018, 90, in press.

5.  Zhan-Ming Ying, Bin Tu, Lan Liu, Hao Tang*, Li-Juan Tang, Jian-Hui Jiang*, Spinach-Based Fluorescent Light-up Biosensors for Multiplexed and label-Free Detection of microRNAs, Chemical Communications, 2018, 54, DOI: 10.1039/C8CC00123E.

6. Xianjun Liu, Meihao Xiang, Zongxuan Tong, Fenglin Wang*, Ru-Qin Yu and Jian-Hui Jiang*, Activatable Fluorescence Probe via Self-immolative Intramolecular cyclization for Histone Deacetylase Imaging in Live Cells and Tissues, Analytical Chemistry, 2018, 90, in press.

7.  Shuaijun Pan*, Rui Guo, Mattias Björnmalm, Joseph J. Richardson, Ling Li, Chang Peng, Nadja Bertleff-Zieschang, Weijian Xu*, Jianhui Jiang*, Frank Caruso, Coatings superrepellent to sub-20 mN m−1 liquids, Nature Materials, 2018, 90, in press.

8. Du-Juan Huang, Zhi-Mei Huang, Hu-Yan Xiao, Zhen-Kun Wu*, Li-Juan Tang, Jian-Hui Jiang*, Protein Scaffolded DNA Tetrads Enable Efficient Delivery and Ultrasensitive Imaging of miRNA through Crosslinking Hybridization Chain Reaction, Chemical Sciences, 2018, in press.

 

2017: 

1. Zhan-ming Ying, Zhan Wu, Bin Tu, Weihong Tan, Jian-Hui Jiang*, Genetically-encoded Fluorescent RNA Sensor for Ratiometric Imaging of MicroRNA in Living Tumor Cells, Journal of the American Chemical Society, 2017, 139, 9779-9782. 

2. Zhenkun Wu, Huanhuan Fan, Nitya Sai Reddy Satyavolu, WenJing Wang, Ryan Lake, Jian-Hui Jiang,* and Yi Lu*, Imaging Endogenous Metal Ions in Living Cells Using a DNAzyme–Catalytic Hairpin Assembly Probe, Angewandte Chemie International Edition, 2017, 56, 8721-8725. 

3. Ying Tang, Xiao-Li Zhang, Li-Juan Tang, Ru-Qin Yu, Jian-Hui Jiang*, In Situ Imaging of Individual mRNA Mutation in Single Cells Using Ligation Mediated Branched Hybrization Chain Reaction (Ligation-bHCR), Analytical Chemistry, 2017, 89, 3445-3451. 

4. Lan Liu, Jin-Wen Liu, Zhi-Mei Huang, Han Wu, Na Li, Li-Juan Tang*, and Jian-Hui Jiang*, Proton-Fueled, Reversible DNA Hybridization Chain Assembly for pH Sensing and Imaging, Analytical Chemistry, 2017, 89, 6944-6947. 

5. Xueli Zhu, Jin Huang, Jinwen Liu, Hang Zhang, Jianhui Jiang*, Ruqin Yu*, Dual enzyme-inorganic hybrid nanoflowers incorporated microfluidic paper-based analytic devices (µPADs) biosensor for sensitive visualized detection of glucose, Nanoscale, 2017, 9, 5658-5663. 

6. Yu-Min Wang, Jin-Wen Liu, Gary Brent Adkins, Wen Shen, Michael Trinh, Lu-Ying Duan, Jian-Hui Jiang*, Wenwan Zhong*, Enhancement of the Intrinsic Peroxidase-Like Activity of Graphitic Carbon Nitride Nanosheets by ssDNAs and Its Application for Detection of Exosomes, Analytical Chemistry, 2017, 89, 12327-12333. 

7. Feng Liu, Hai-Juan Liu, Xian-Jun Liu, Wen Chen, Feng-Lin Wang*, Ru-Qin Yu, and Jian-Hui Jiang*, Mitochonrion-Targeting, Environment-Sensitive Red Fluorescent Probe for Highly Sensitive Detection and Imaging of Vicinal Dithiol-Containing Proteins, Analytical Chemistry, 2017, 89, 11203-11207.

 

2016: 

1. Xiang-Cheng Lin, Ting Zhang, Lan Liu, Hao Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Mass Spectrometry Based Ultrasensitive DNA Methylation Profiling Using Target Fragmentation Assay, Analytical Chemistry, 2016, 88, 1083-1087. 

2. Jin-Wen Liu, Yu-Min Wang, Liu Xu, Lu-Ying Duan, Hao Tang*, Ru-Qin Yu, and Jian-Hui Jiang*, Melanin-like Nanoquencheron Graphitic Carbon Nitride Nanosheetsfor Tyrosinase Activity and Inhibitor Assay, Analytical Chemistry, 2016, 88, 8355-8358    

3. Chong-Hua Zhang, Ling-Wei Liu, Ping Liang, Li-Juan Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Plasmon Coupling Enhanced Raman Scattering Nanobeacon for Single-Step, Ultrasensitive Detection of Cholera Toxin, Analytical Chemistry, 2016, 88, 7447-7452. 

4. Wei Liu, Si-Jia Liu, Yong-Qing Kuang*, Feng-Yan Luo, Jian-Hui Jiang*, Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells, Analytical Chemistry, 2016, 88, 7867-7872. 

5. Xiang-Cheng Lin, Xiang-Nan Wang, Lan Liu, Qian Wen*, Ru-Qin Yu, Jian-Hui Jiang*, Surface Enhanced Laser Desorption Ionization of Phospholipids on Gold Nanoparticles for Mass Spectrometric Immunoassay, Analytical Chemistry, 2016, 88, 9881-9884. 

6. Ying Tang, Zhan Wu*, Chong-Hua Zhang, Xiao-Li Zhang and Jian-Hui Jiang*, Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors, Chemical Communications, 2016, 52, 3631-3634. 

7. Wenfang Du, Mengmei Lv, Junjie Li, Ruqin Yu*, Jianhui Jiang,* A Ligation-Based Loop-Mediated Isothermal Amplification (Ligation-LAMP) Strategy for Highly Selective MicroRNA Detection, Chemical Communications, 2016, 52, 12721-12724 

8. Chonghua Zhang, Ying Tang, Ying-Ying Sheng, Hui Wang, Zhan Wu*, Jianhui Jiang,* Ultrasensitive Detection of MicroRNAs using Catalytic Hairpin Assembly Coupled with Enzymatic Repairing Amplification, Chemical Communications, 2016, 52, 13584-13587. 

9. Wang Xu, Zebing Zeng, Jian-Hui Jiang,* Young-Tae Chang,* Lin Yuan*, Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes, Angewandte Chemie International Edition, 2016, 55, 13658-13699. 

10. Mei-Hao Xiang, Jin-Wen Liu, Na Li, Hao Tang*, Ru-Qin Yu and Jian-Hui Jiang*, Fluorescent Graphitic Carbon Nitride Nanosheet Biosensor for Highly Sensitive, Label-Free Detection of Alkaline Phosphatase, Nanoscale, 2016, 8, 4727-4732. 

11. Jin-Wen Liu, Ying Luo, Yu-Min Wang, Lu-Ying Duan, Jian-Hui Jiang*, and Ru-Qin Yu*, Graphitic Carbon Nitride Nanosheets-based Ratiometric Fluorescent Probe for Highly Sensitive Detection of H2O2 and Glucose, ACS Applied Materials & Interfaces, 2016, 8, 33439-33445.

 

2015: 

1. Zhan Wu, Gao-Qin Liu, Xiao-Li Yang, Jian-Hui Jiang*, Electrostatic Nucleic Acid Nanoassembly Enables Hybridization Chain Reaction in Living Cells for Ultrasensitive mRNA Imaging, Journal of the American Chemical Society, 2015, 137, 6829-6836. 

2. Zhen-Kun Wu, Dian-Ming Zhou, Zhan Wu*, Xia Chu, Ru-Qin Yu and Jian-Hui Jiang*, Single-Base Mismatch Discrimination by T7 Exonuclease with Target Cyclic Amplification Detection, Chemical Communications, 2015, 51, 2954-2956.

3. Qing Li, Yan-Dan Wang, Guo-Li Shen, Hao Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Split Aptamer Mediated Endonuclease Amplification for Small-Molecule Detection, Chemical Communications, 2015, 51, 4196-4199. 

4. Jian Chen*, Weibang Zhong, Ying Tang, Zhan Wu, Ya Li, Pinggui Yi*, Jianhui Jiang*, Amphiphilic BODIPY-Based Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Patterning and Dual-Color Cell Imaging, Macromolecules, 2015, 48, 3500-3508.

 

2014: 

1. Liping Qiu, Tao Zhang, Jianhui Jiang*, Cuichen Wu, Guizhi Zhu, Mingxu You, Xigao Chen, Liqin Zhang, Cheng Cui, Ruqin Yu, Weihong Tan*, Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment, Journal of the American Chemical Society, 2014, 136, 13090-13093.

2. Dian-Ming Zhou, Wen-Fang Du, Qiang Xi, and Jian-Hui Jiang*, A Novel Isothermal Nucleic Acid Amplification Strategy by Cyclic Enzymatic Repairing for Highly Sensitive MicroRNA Detection, Analytical Chemistry, 2014, 86, 6763-6767.

 3. Qiang Xi, Dianming Zhou, Jin-Wen Liu, Ru-Qin Yu*, Jian-Hui Jiang*, Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification, Analytical Chemistry, 2014, 86, 1361-1365. 

4. Qing Li, Lin Liu, Jin-Wen Liu, Jian-Hui Jiang*, Ru-Qin Yu, Xia Chu*, Nanomaterial-based fluorescent probes for live-cell imaging, Trends in Analytical Chemistry, 2014, 58, 130-144. 

5. Xin-Min Nie, Rong Huang, Cai-Xia Dong, Li-Juan Tang, Rong Gui*, Jian-Hui Jiang*, Plasmonic ELISA for the ultrasensitive detection of Treponema pallidum, Biosensors and Bioelectronics, 2014, 58, 314-319. 

6. Qian Wen, Si-Jia Liu, Li-Juan Tang*, Ying Tang, Jian-Hui Jiang*, Gold Nanoparticle Supported Phospholipid Membranes as A Biomimetic Biosensor Platform for Phosphoinositide Signaling Detection, Biosensors and Bioelectronics, 2014, 62, 113-119.


2013: 

1. Yu Wang, Lijuan Tang, Jianhui Jiang*, SERS-Based, Homogeneous, Multiplexed Immunoassay with Antibody-Fragments Decorated Gold Nanoparticles, Analytical Chemistry, 2013, 85, 9213-9220. 

2. Qian Wen, Yi Gu, Li-Juan Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Peptide-Templated Gold Nanocluster Beacon as a Sensitive, Label-Free Sensor for Protein Post-translational Modification Enzymes, Analytical Chemistry, 2013, 85, 11681-11685. 

3. Zhan Wu, Zhen-Kun Wu, Hao Tang, Li-Juan Tang, Jian-Hui Jiang*, Activity-Based DNA-Gold Nanoparticle Probe as Colorimetric Biosensor for DNA Methyltransferase/Glycosylase Assay, Analytical Chemistry, 2013, 85, 4376-4383. 

4. Liangliang Zhang, Jingjin Zhao, Min Duan, Hua Zhang, Jianhui Jiang*, Ruqin Yu*, Inhibition of dsDNA-Templated Copper Nanoparticles by Pyrophosphate as a Label-Free Fluorescent Strategy for Alkaline Phosphatase Assay, Analytical Chemistry, 2013, 85, 3797-3801.

5. Weihong Tan*, Michael J. Donovan, Jianhui Jiang*, Aptamers from Cell-Based Selection for Bioanalytical Applications, Chemical Reviews, 2013, 113, 2842-2862. 

6. Yu Wang, Xianghua Deng, Jinwen Liu, Hao Tang*, Jianhui Jiang*, Surface Enhanced Raman Scattering Based Sensitive Detection of Histone Demethylase Activity using Formaldehyde-Selective Reactive Probe, Chemical Communications, 2013, 49, 8489-8491. 

7. Cuihua Chen, Dianming Zhou, Hao Tang*, Jianhui Jiang*, A Sensitive, Homogeneous Fluorescence Assay of Thymine DNA Glycosylase Activity with Exonuclease-Mediated Amplification, Chemical Communications, 2013, 49, 5874-5876. 

8. Yong Huang*, Jing Zhu, Guiyin Li, Zhencheng Chen, Jian-Hui Jiang*, Guo-Li Shen, Ru-Qin Yu, Electrochemical detection of point mutation based on surface hybridization assay conjugated Allele-Specific polymerase chain reaction, Biosensors and Bioelectronics, 2013, 42, 526-531. 

9. Dianming Zhou, Qiang Xi, Manfen Liang, Cuihua Chen, Li-Juan Tang*, Jian-Hui Jiang*, Graphene Oxide-Hairpin Probe Nanocomposite as A Homogeneous Assay Platform for DNA Base Excision Repair Screening, Biosensors and Bioelectronics, 2013, 41, 359-365. 

10. Cui Wang, Hui Zhou, Wenping Zhu, Hongbo Li, Jianhui Jiang*, Guoli Shen, Ruqin Yu*, Ultrasensitive electrochemical DNA detection based on dual amplification of circular strand-displacement polymerase reaction and hybridization chain reaction, Biosensors and Bioelectronics, 2013, 42, 324-328.


奖励与荣誉

2017 科技部创新人才推进计划中青年科技创新领军人才

2016 湖南省教学成果三等奖(排名第五)

2014 国家自然科学二等奖(排名第三)

2011 湖南省优秀博士论文导师

2008 教育部自然科学一等奖(排名第三)

2005 湖南省青年科技奖

2003 国家自然科学二等奖(排名第五)

2002 Buchi 国际近红外光谱学奖(排名第一)

2002 湖南省科学技术进步奖一等奖

2002 湖南省自然科学优秀学术论文一等奖