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邱丽萍

发布于:2018-01-04 星期四 14:16:03 点击数:16793

邱丽萍,教授,博士生导师,国家优青,洪堡学者,湖湘英才



基本信息


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2014年于湖南大学获分析化学博士学位,毕业后留校任教。2012-2014年,赴美国佛罗里达大学进行交流学习。2015-2016年赴荷兰拉德堡德大学医学研究中心进行博士后研究。2017年,以洪堡学者身份赴德国联邦材料研究与测试研究所进行深造。获国家优秀青年基金资助,入选中国科协“青年人才托举工程”,入选“湖湘青年英才”计划。长期从事分析化学与生物医学等交叉学科领域的研究工作,在核酸适体的筛选、化学生物传感新方法的研究以及生物医学检测等方面积累了丰富的经验,并取得了阶段性的进展,以第一/通讯作者在Nat Commun、Chem、J Am Chem Soc等期刊上发表高水平学术论文20余篇。

教育背景

2012–2014,联合培养博士,美国佛罗里达大学

2009–2014,博士,湖南大学

2005–2009,本科,湖南大学


工作履历

2014-至今助理教授,副教授, 教授,湖南大学化学化工学院

2017-2018,洪堡学者,德国联邦理工材料研究与测试中心(BAM)

2015-2016,博士后,荷兰拉德堡德大学医学研究中心肿瘤免疫系


学术兼职

国家卫生健康委出生缺陷研究与预防重点实验室双聘首席研究员

研究领域

化学生物传感、生物纳米技术、肿瘤免疫


科研项目

1. 湖南省抗击新冠肺炎疫情应急专项,2020SK3008,家庭简易式新型冠状病毒感染检测技术与试剂盒,2020/03-2021/03,在研,主持;

2. 国家自然科学基金优秀青年科学基金项目,21922404,细胞成像,2020/01-2022/12,在研,主持;

3  国家重点研发计划项目,2018YFC1602900,新型生物识别材料库的构建及其制备关键技术研究,2018/12-2021/12,在研,子课题负责人;

4  湖南省科技创新计划项目,2018RS3035,湖湘青年英才,2018/10-2021/10,在研,主持;

5  国家自然科学基金重大研究计划培育项目,91753109,基于核酸适配体的RNA动态化学修饰研究新方法,2018/01-2020/12,在研,主持;

6  湖南省自然科学基金青年科学基金项目,2018JJ3034,构建基于细胞膜表面的核酸荧光探针用于细胞间信号传递过程的研究,2018/01-2020/12,在研,主持;

7  中国科协“青年人才托举工程”,2016QNRC001,基于功能核酸的单免疫细胞分析,2016/01-2018/12,结题,主持;

8  国家自然科学基金青年科学基金项目,21505039,细胞膜定位功能核酸探针的构建及其在细胞外微环境荧光成像应用的研究,2016/01-2018/12,结题,主持。


学术成果

代表性论文

1.  SitaoXie, Yulin Du, Yu Zhang, Zhimin Wang, Dailiang Zhang, Lei He, Liping Qiu,* Jianhui Jiang* and Weihong Tan*, Aptamer-based Optical Manipulation of Protein Subcellular Localization in Cells. Nat. Commun., 2020,11, 1347, 1-10.

2.  Chao Liu, Zike Huang, Wei Jiang, Xiaojing Liu, Jin Li, Xiaoyan Han, Haijun Tu, Liping Qiu* andWeihong Tan*, Programmable pH-Responsive DNA Nanosensors for Imaging Exocytosis and Retrieval of Synaptic Vesicles. Anal. Chem., 2020, 92, 3620.3626.

3.  Xiaojing Xing,* Jin Li, Liping Qiu* and Weihong Tan, A molecular recognition-activatable DNAnanofirecrackerenables signal-enhanced imaging in living cells. Chem. Comm., 2020, 56, 3131--3134.

4.  LiyanZheng, XiaoXiao Hu, Hui Wu, Liuting Mo, Sitao Xie, Jin Li, Cheng Peng, Shujuan Xu, Liping Qiu* and Weihong Tan*, In vivo Monocyte/Macrophage-hitchhiked IntratumoralAccumula-tionof Nanomedicines for Enhanced Tumor Therapy. J. Am. Chem. Soc. 2020, 142, 382-391.

5.  Jin Li, Kanyu Xun, Ke Pei, Xiaojing Liu, Xueyu Peng, Yulin Du, Liping Qiu* andWeihong Tan*, A cell membrane-anchored DNA nano-platform for programming cellular interactions. J. Am. Chem. Soc. 2019, 141, 45, 18013-18020.

6.  Jianmei Zou, Muling Shi, Xiaojing Liu, Cheng Jin, Xiaojing Xing, Liping Qiu* andWeihong Tan, Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy. Anal. Chem., 2019, 91, 2425−2430

7.  Long Li, Ying Jiang, Cheng Cui, Yu Yang, Penghui Zhang, Kimberly Stewart, Xiaoshu Pan, Xiaowei Li, Lu Yang, Liping Qiu* and Weihong Tan*, Modulating Aptamer Specificity with pH-Responsive DNA Bonds. J. Am. Chem. Soc., 2018, 140, 13335–13339

8.  Yifan Lyu, I-Ting Teng, Liqin Zhang, Yian Guo, Ren Cai, Xiaobing Zhang, Liping Qiu* andWeihong Tan*, Comprehensive Regression Model for Dissociation Equilibria of Cell-Specific Aptamers. Anal. Chem. 2018, 90, 10487−10493

9.  Yuan Liu, Weijia Hou, Lian Xia, Cheng Cui, Shuo Wan, Ying Jiang, Yu Yang, Qiong Wu, Liping Qiu* andWeihong Tan*, ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy. Chem. Sci., 2018, 9, 7505–7509

10.  Jianmei Zou, Cheng Jin, Ruowen Wang, Hailan Kuai, Lili Zhang, Xiaobing Zhang, Juan Li, Liping Qiu* and Weihong Tan*, Fluorinated DNA Micelles: Synthesis and Properties. Anal. Chem. 2018, 90, 6843−6850

11.  Liping Qiu, Hui Liu, Jianhui Jiang*andWeihong Tan*, DNA-nanostructure-templated precise biomineralization. Natl. Sci. Rev. 2018, 0. 1-2

12.  Liping Qiu, Michael Valente, Yusuf Dolen, Eliezer Jäger, MartinterBeest, Liyan Zheng, Carl G. Figdor*andMartijn Verdoes*, Endolysosomal-Escape Nanovaccines through adjuvant-induced tumor antigen assembly for enhanced effector CD8+ T cell activation. Small, 2018, 1703539

13.  SitaoXie, Liping Qiu*, Liang Cui, Honglin Liu, Hao Liang, Ding Ding, Lei He, Huixia Liu, Zhou Chen, Xiaobing ZhangandWeihong Tan*, Reversible and Quantitative Photoregulation of Target Proteins. Chem, 2017, 3, 1021–1035

14.  Liqin Zhang, Shuo Wan, Ying Jiang, Yanyue Wang, Ting Fu, Qiaoling Liu, Zhijuan Cao, Liping Qiu* and Weihong Tan*, Molecular Elucidation of Disease Biomarkers at the Interface of Chemistry and Biology. J. Am. Chem. Soc. 2017, 139, 2532−2540

15.  Liping Qiu, Tao Chen, Ismail öçsoy, Emir Yasun, Cuichen Wu, Guizhi Zhu, Mingxu You, Da Han, Jianhui Jiang, Ruqin Yu and Weihong Tan*, A Cell-Targeted, Size-Photocontrollable, Nuclear-UptakeNanodrugDelivery System for Drug-Resistant Cancer Therapy. Nano Lett., 2015, 15 (1), 457–463

16.  Liping Qiu, Tao Zhang, Jianhui Jiang*, Cuichen Wu, Guizhi Zhu, Mingxu You,XigaoChen, Liqin Zhang, Cheng Cui, Ruqin Yu and Weihong Tan*, Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment. J. Am. Chem. Soc. 2014, 136 (38), 13090–13093

17.  Liping Qiu, Cuichen Wu, Mingxu You, Da Han, Tao Chen, Guizhi Zhu, Jianhui Jiang, Ruqin YuandWeihong Tan*, A Targeted, Self-delivered and Photocontrolled Molecular Beacon for Spatiotemporal mRNA Detection in Living Cells. J. Am. Chem. Soc. 2013, 135 (35), 12952 − 12955

 







奖励与荣誉

湖南省优秀博士论文