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黄静

发布于:2018-10-18 星期四 12:37:05 点击数:4224

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黄静

教授、博士生导师

E-mail:huangjing16@hnu.edu.cn


基本信息

黄静,博士生导师,湖南大学生物学院、化学生物传感与计量国家重点实验室,湖南大学化学生物学与纳米医学研究所教授。2010年毕业于武汉大学化学与分子科学学院,获化学生物学博士学位。2010年年底赴美国国立卫生研究院(NIH)从事博士后研究。2013,2014连续两年获得美国国立卫生研究院(NIH)优秀博士后研究员奖。2017年入选“湖南省青年百人计划”。主要从事交叉学科研究,包括化学生物学,细胞生物学,分子生物学等学科交叉。已在Molecular Cell, Angew. Chem. Int. Ed.,Nucleic Acids Research, J Am Chem Soc.,等国际期刊上发表论文30多篇;主持国家自然科学基金项目多项。

电子邮箱:huangjing16@hnu.edu.cn


招聘信息:

由于课题研究与项目研发的需要,本实验室招聘:

1、特聘研究岗位(研究员、副研究员、助理研究员与研究助理);

2、招聘博士后;

3、每年招收博士与硕士研究生。

有意者请联系并将个人简历发送至 huangjing16@hnu.edu.cn邮箱。




教育背景

2001-2005 湖南农业大学 应用化学专业本科

2005-2010 武汉大学 化学生物学博士



工作履历

2010 -2015在美国国立卫生研究院(NIH)从事博士后研究

2016年至今 湖南大学生物学院,化学生物学与纳米医学研究所

2017年至今 化学生物传感与计量国家重点实验室


研究领域

1、抗癌靶向小分子的筛选及其生物活性研究

2、基因损伤修复机理与基因组的稳定性

3、化学生物传感探针


科研项目

1.    国家自然科学基金青年项目,21708007,DNA转位酶FANCM抑制剂的筛选及其在DNA交联损伤修复通路中的作用研究,2018.01-2020.12,主持。

2.     国家自然科学基金面上项目,31871365,基于DNA纤维荧光原位杂交技术的DNA交联损伤修复研究,2019.01-2022.12,主持。

3.     国家自然科学基金海外合作项目,21828701,泛素化组蛋白H4探针的设计合成以及在基因损伤修复中的应用,2019.01-2020.12

4.     黄静,湖南省自然科学基金青年项目,2018JJ3030,基于活性氧激活的RNA G-四链体探针的设计、合成及其生物活性研究,2018.01-2020.12,主持。

学术成果


  1. Jing Huang*, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman*, Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2, Cell Reports, 2019, 27, 1794-1808.

  2. Lu Liu, Yaya Zhang, Jia Zhou, Jihuan Yang, Cheng Zhong, Yueshou Zhang, Yu Luo, Yang Fua, Jing Huang*, Zhibin Song*, Yiyuan Peng, Design of a quinazolinone-based environment-sensitive fluorescent dye: Solvatochromic fluorescence and application for one-photon and two-photon bioimaging, Dyes and Pigments, 2019, 165, 58-64.

  3. Marina A Bellani, Jing Huang, Manikandan Paramasivam, Durga Pokharel, Julia Gichimu, Jing Zhang, Michae M. Seidman*, Imaging cellular responses to antigen tagged DNA damage, DNA Repair, 2018, 71, 183-189.

  4. Jing Huang, Himabindu Gali, Julia Gichimu, Marina A. Bellani, Durga Pokharel, Manikandan Paramasivam, Michael M. Seidman*, Single Molecule Analysis of Laser Localized Psoralen Adducts, Journal of Visualized Experiments, 2017122, e55541.

  5. Chen Ling, Jing Huang, Zhijiang Yan, Yongjiang Li, Mioko Ohzeki, Masamichi Ishiai, Dongyi Xu, Minoru Takata, Michael Seidman*, and Weidong Wang*, Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks, Cell Discovery, 2016, 2, 16047.

  6. Florian Rohleder#, Jing Huang#, Yutong Xue, Jochen Kuper, Adam Round, Michael Seidman*, Weidong Wang*, and Caroline Kisker*, FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks, Nucleic Acids Research, 2016, 44, 3219–3232.

  7. Jing Huang, Himabindu Gali, Manikandan Paramasivam, Parameswary Muniandy, Julia Gichimu, Marina A. Bellani and Michael M. Seidman*, Single molecule analysis of laser localized interstrand crosslinks. Frontiers in Genetics, 2016, 7.

  8. Taraswi Banerjee, Joshua A. Sommers, Jing Huang, Michael M. Seidman, Robert M. Brosh, Jr*, Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress. Current Biology, 2015, 25, 2830-2838.

  9. Xiaolin Li, Evandro Fei Fang, Morten Scheibye-Knudsen, Honghua Cui, Lu Qiu, Jian Li, Yuping He, Jing Huang, Vilhelm A Bohr, Tzi Bun Ng*, Hongwei Guo*, Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis, Science Report2014, 4, 6434.

  10. Jing Huang, Shuo Liu, Marina A. Bellani, Arun Kalliat Thazhathveetil, Chen Ling, Johan P. de Winter, Yinsheng Wang, Weidong Wang, and Michael M. Seidman*, “The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks”, Molecular Cell. 2013, 52, 434–446.

  11. Daniel R. McNeill, Manikandan Paramasivam, Jakita Baldwin, Jing Huang, Vaddadi N. Vyjayanti, Michael M. Seidman and David M. Wilson III*, “NEIL1responds and binds to psoralen-induced DNA interstrand crosslinks”, Journal of Biological Chemistry, 2013, 288, 12426-12436.

  12. Venkateswarlu Popuri, Jing Huang, Mahesh Ramamoorthy, Takashi Tadokoro, Deborah L Croteau, Vilhelm A Bohr*, RECQL5 plays co-operative and complementary roles with WRN syndrome helicase, Nucleic Acids Research, 2013, 41, 881-899.

  13. Xiaolin Wang#, Jing Huang#, Yangyang Zhou, Shengyong Yan, Xiaocheng Weng, Xiaojun Wu, Minggang Deng, Xiang Zhou*Conformational Switching of G-Quadruplex DNA by PhotoregulationAngewandte Chemie International Edition, 2010 , 49, 5305-539.

  14. Bai Minghui, Huang Jing, Zheng Xiaolong, Song Zhibin, Tang Miru, Mao Wuxiang, Yuan Libo, Wu Jun, Weng Xiaocheng, Zhou Xiang*, Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives, Journal of the American Chemical Society, 2010 , 132, 15321-15327.

  15. Yuhao Du, Jing Huang, Xiaocheng Weng, Xiang Zhou*, Specific recognition of DNA by small molecules.Current Medicinal Chemistry, 2010, 17, 173-189.

  16. Liang Xu, Dan Zhang, Jing Huang, Minggang Deng, Ming Zhang, Xiang Zhou *High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex, Chemical Communications, 2010, 46 :743-745.

  17. Yuhao Du, Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou*, Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA, Bioorganic & Medicinal Chemistry, 2010, 18, 4149-4153.

  18. Jing Huang, Ming Wang, Yangyang Zhou; Xiaocheng Weng, Liang Shuai, Xiang Zhou *, Deqing Zhang, Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, Bioorganic & Medicinal Chemistry, 2009 , 17, 7743-7748.

  19. Jing Huang#, Guorui Li#, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex, Chemical Communications, 2009, 8, 902-904.

  20. Ming Zhang, Jing Huang, Minggang Deng, Xiaocheng Weng, Heng Ma, Xiang Zhou *, Sensitive and Visual Detection of Adenosine by a Rationally Designed FokI-Based Biosensing Strategy, Chemistry – An Asian Journal, 2009, 4,1420-1423.

  21. Lin Wu, Li Yang, Jing Huang, Lixia Zhang, Xiaocheng Weng, Xiaolian Zhang, Chao Shen, Xiang Zhou *, Congyi Zheng, Cationic Ester Porphyrins Cause High Levels of Phototoxicity in Tumor Cells and Induction of Apoptosis in HeLa CellsChemistry & Biodiversity, 2009 , 6, 1066-1076.

  22. Shao R Wang, Dan Zhang, Feng L Luo, Lin Liu, Xiao C Weng, Jing Huang, Guo R Li, Xiao L Zhang, Xiang Zhou *, Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation of c-myc in Hep G2 cellsJournal of Porphyrins & Phthalocyanines, 2009, 13, 865-875.

  23. Guorui Li#, Jing Huang#, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand, Chemical Communications, 2008, 38,4564-4566.

  24. Zhibin Song, Xiaocheng Weng, Liwei Weng, Jing Huang, Xiaolin Wang, Minghui Bai, Yangyang Zhou, Guangfu Yang, Xiang Zhou *, Synthesis and Oxidation-Induced DNA Cross-Linking Capabilities of Bis(catechol) Quaternary Ammonium Derivatives, Chemistry - A European Journal, 2008, 14, 5751-5754.

  25. Lixia Zhang, Jing Huang, Lige Ren, Minghui Bai, Lin Wu, Baoping Zhai, Xiang Zhou *, Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase, Bioorganic & Medicinal Chemistry, 2008, 16 303-312.

  26. Boqiao Fu#, Jing Huang#, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du Xiaojun Wu, Xiang Zhou *, Guangfu Yang, Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands, Chemical Communications, 2007, 31, 3264-3266.

  27. An-Ming Zhang#, Jing Huang#, XiaoCheng Weng, JinXi Li, Lige Ren, ZhiBin Song, XiaoQin Xiong, Xiang Zhou *, XiaoPing Cao, Yan Zhou, A water-soluble, octacationic zinc phthalocyanine as molecular probe for nucleic acid secondary structure, Chemistry & Biodiversity, 2007, 4, 215-223.

  28. Lixia Zhang, Lige Ren, Minghui Bai, Liwei Weng, Jing Huang, Lin Wu, Minggang Deng, Xiang Zhou *, Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups, Bioorganic & Medicinal Chemistry, 2007, 15, 6920-6926.

  29. XiaoCheng Weng, Jing Huang, Song Wu, LiGe Ren, LiWei Weng, ShuGao Zhu, Xiang Zhou *, Specific recognition of loop DNA by dicationic PorphyrinsChemistry & Biodiversity, 2007, 4, 1501-1507.

  30. Lige Ren, Anming Zhang, Jing Huang, Ping Wang, Xiaocheng Weng, Lixia Zhang, Feng Liang, Zheng Tan, Xiang Zhou *, Quaternary ammonium zinc phthalocyanine: Inhibiting telomerase by stabilizing G quadruplexes and inducing G-quadruplex structure transition and formation, Chembiochem, 2007, 8, 775-780.

  31. Xiaocheng Weng, Lige Ren, Liwei Weng, Jing Huang, Shugao Zhu, Xiang Zhou*, Linhong Weng, Synthesis and biological studies of inducible DNA cross-linking agents, Angewandte Chemie International Edition, 2007, 46, 8020-8023.


奖励与荣誉

2017 湖南省“青年百人”计划

2014美国国立卫生研究院(NIH)优秀博士后研究员奖

2013美国国立卫生研究院(NIH)优秀博士后研究员奖