发布于:2018-07-06 星期五 10:03:17 点击数:16151

游常军 Changjun You


E-mail: changjun@hnu.edu.cn

研究方向: 生命分析化学、化学生物学

Reserch Interests: Chemical Modifications & Molecular Toxicity 




游常军,湖南大学化学化工学院、化学生物传感与计量学国家重点实验室教授、博士生导师,Chemical Society Reviews、Journal of the American Chemical Society、 Analytical Chemistry、Chemical Research in Toxicology以及Science China Chemistry等国内外学术期刊审稿人。博士毕业于华中农业大学生命科学技术学院,获得理学博士学位,随后进入美国加州大学河滨分校化学系开展博士后研究工作。课题组目前的研究方向为生命分析化学和化学生物学,主要涉及生物质谱分析、核酸化学修饰及分子毒理学等方面的相关研究。至今已在Accounts of Chemical Research、Nature Chemical Biology、Nature Protocols以及Nucleic Acids Research等国际权威期刊发表论文30余篇。


Dr. Changjun You is currently a Professor in the College of Chemistry and Chemical Engineering at Hunan University. He received his Ph.D. in Biochemistry and Molecular Biology from Huazhong Agricultural University, and he conducted postdoctoral research in the Department of Chemistry at the University of California-Riverside. His research interests span a wide range of topics in bioanalytical chemistry, chemical biology, and molecular toxicology. Specially, he has made significant progress in developing the mass spectrometry-based quantitative strategies for assessing the cytotoxic, mutagenic and carcinogenic potentials of chemically modified biomacromolecules that can be induced by various endogenous and environmental genotoxic agents. To date, he has published more than 30 research articles in highly reputed international journals such as Accounts of Chemical Research, Nature Chemical Biology, Nature Protocols, PNAS and Nucleic Acids Research.

Selected Publications

1. You, C., Dai, X., and Wang, Y. Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation. Nucleic Acids Research, 2017, 45: 9059-9067.

2. You, C., and Wang, Y. Mass spectrometry-based quantitative strategies for assessing the biological consequences and repair of DNA adducts. Accounts of Chemical Research, 2016, 49: 205-213.

3. You, C., Wang, P., Nay, S., Wang, J., Dai, X., O’Connor, T., and Wang, Y. Roles of AAG, ALKBH2 and ALKBH3 in the repair of carboxymethylated and ethylated thymidine lesions. ACS Chemical Biology, 2016, 11: 1332-1338.

4. You, C., and Wang, Y. Quantitative measurement of transcriptional inhibition and mutagenesis induced by site-specific DNA lesions in vitro and in vivo. Nature Protocols, 2015, 10: 1389-1406.

5. You, C., Wang, J., Dai, X., and Wang, Y. Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA. Nucleic Acids Research, 2015, 43: 1012-1018.

6. You, C., Wang, P., Dai, X., and Wang, Y. Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II. Nucleic Acids Research, 2014, 42:13706-13713.

7. You, C., Swanson, A., Dai, X., Yuan, B., Wang, J., and Wang Y. Translesion Synthesis of 8,5'-Cyclopurine-2'-deoxynucleosides by DNA Polymerases η, ι, and ζ. Journal of Biological Chemistry, 2013, 288, 28548-28556.

8. You, C., Dai, X., Yuan, B., and Wang, Y. Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human Cells. Journal of Biological Chemistry, 2012, 287:40915-23.

9. You, C., Dai, X., Yuan, B., Wang, J., Wang, J., Brooks, P., Niedernhofer, L., and Wang, Y. A quantitative assay for assessing the effects of DNA lesions on transcription. Nature Chemical Biology, 2012, 8, 817-822.