header
王雪强

发布于:2018-01-05 星期五 09:48:35 点击数:16567

教授,博士生导师

化学生物传感与计量学国家重点实验室子科学与分子医学实验室

邮箱: wangxq@hnu.edu.cn

课题组网站:http://www.wangxqgroup.com/    ORCID: http://orcid.org/0000-0003-1631-9158

基本信息

                                                                                                                   王雪强.png

       王雪强,湖南大学,化学生物传感与计量学国家重点实验室, 分子科学与分子医学实验室,化学与化工学院教授,博士生导师。2007年本科毕业于临沂师范学院化学系。2012年在中国科学院上海有机化学研究所 (SIOC) 获得硕士学位,导师:吕龙、沈其龙研究员。2015年在西班牙加泰罗尼亚化学研究所 (ICIQ) 获得博士学位,导师:Ruben Martin教授。随后在美国麻省理工学院 (MIT) 开展博士后研究工作,导师:美国三院院士Stephen L. Buchwald教授。目前,已在国际著名期刊JACS, Angew. 等发表学术论文20余篇。课题组主要研究方向为核酸化学与癌症靶向治疗,课题组热烈欢迎满怀理想的青年俊的加盟!

教育背景

2012.11-2015.11         博士研究生,         西班牙加泰罗尼亚化学研究所 (导师:Ruben Martin教授)

2009.09-2012.07         硕士研究生,         中国科学院上海有机化学研究所 (导师:吕龙研究员、沈其龙研究员)

2003.09-2007.07         大学本科,            临沂师范学院



工作履历

2017.08-至今                    湖南大学化学与化工学院

2016.04-2017.08              美国麻省理工学院 (博士后导师:Stephen L. Buchwald教授)

2007.09-2009.07              中国科学院上海有机化学研究所 (导师:游书力研究员)

研究领域

课题组研究方向靶向药物分子设计

酸化学生物学

1)非天然碱基设计、合成与生物医学应用

2)功能核酸结构优化与功能开拓

症的靶向治疗

1)靶向药物连接子化学

2)靶向药物在实体瘤治疗中的应用

科研项目

1.  湖南大学高层次人才启动基金,主持,2017-2025

2.  国家重点研发计划“高通量脱氧核糖核酸(DNA)合成新技术及仪器研发”项目,参与,2019-2024

3.  湖南创新型省份建设专项-湖湘青年英才,主持,2019-202

4.  湖南省重点研发计划“抗肿瘤药物生物合成及恶性肿瘤靶向治疗研究”,子课题负责人,2019-2022

学术成果

课题组代表性论文:


2020年


13) Targeting PTK7 with a Modularly Synthesized Aptamer-CA4 Conjugate for the Efficient and Safty Treatment of

      Colorectal Cancer

      Dan Wang,# Yongbo Peng,# Zhengyu Deng,# Yan Tan, Yuanye Su, Hailan Kuai, Lili Ai, Zhiyong Huang,

      Xue-Qiang Wang,* and Weihong Tan,*

      Advanced Therapeutics, 2020, accepted


12)  Aptamer Enables Consistent Maytansine Delivery Through Maintaining Receptor Homeostasis for HER2 Targeted 

       Cancer Therapy

       Yan Tan, Yongbo Peng, Lili Ai, Yingying Li, Yixin Qu, Dan Wang, Yuanye Su, Tanggang Deng, Ting Fu, Zilong Zhao,

       Xue-Qiang Wang*, and Weihong Tan*

       Bioconjugate Chem. 2020, 31, ASAP DOI: 10.1021/acs.bioconjchem.0c00250


          11)Targeted delivery of emodin to adipocytes by aptamer-functionalized PEG-PLGA nanoparticles in vitro

                 Bo Yu,Ying Pu,Jun Liu,Jie Liao,Ke Chen,Jiani Zhang,Wen Zhong,Yalan Hu,Xue-Qiang  Wang*, Bo Liu*

                 Huixia Liu*,Weihong Tan  

                Journal of Drug Delivery Science and Technology, 2020, 57, DOI: 10.1016/j.jddst.2020.101739


          10)Conjugating Aptamer and Mitomycin C with Reductant-Responsive Linker Leading to Synergistically Enhanced

                 Anticancer Effect

                 Qiuxia Yang, Zhengyu Deng, Dan Wang, Jiaxuan He, Dailiang Zhang, Yan Tan, Tianhuan Peng

                 Xue-Qiang Wang*, Weihong Tan*

                J. Am. Chem. Soc. 2020,  142, 2532-2540


         9)Molecularly Engineering Triptolide with Aptamers for High Specificity and Cytotoxicity for Triple-Negative Breast

              Cancer

              Jiaxuan He, Tianhuan Peng, Yongbo Peng, Lili Ai, Zhengyu Deng, Xue-Qiang Wang*, Weihong Tan*

              J. Am. Chem. Soc. 2020, DOI: 10.1021/jacs.9b10510


         8)Polymeric Engineering of Aptamer–Drug Conjugates for Targeted Cancer Therapy

              Zhengyu Deng, Qiuxia Yang, Yongbo Peng, Jiaxuan He, Shujuan Xu, Dan Wang, Tianhuan Peng, Ruowen Wang,

              Xue-Qiang Wang*, Weihong Tan*

              Bioconjugate Chem. 2020, 31, 37-42.


2019年


         7)Functional nucleic acids for cancer theranostics

              Tianhuan Peng, Zhengyu Deng, Jiaxuan He, Yingying Li, Yan Tan, Yongbo Peng, Xue-Qiang Wang*,    

              Weihong Tan*

              Coordination Chemistry Reviews, 2019, DOI: 10.1016/j.ccr.2019.213080


        6)Deuterated Aryl Alkyl Ethers Synthesis via Nucleophilic Etherification of Aryl Alkyl Ethers and Thioethers with

            Deuterated Alcohols

                Shuai Li, Xia Wang, Xinge Yang*, Guiquan Yu, Xue-Qiang Wang*

            Synlett 2019, 30, 1805-1809

         5)Rapid Amination of Methoxy Pyridines with Aliphatic Amines

               Xia Wang,Cheng-Yu Long,Min-Hui Su,Yi-Xin Qu,Shen-Huan Li,Xiao-Jing Zhang,Xue-Qiang Wang*

               Org. Process Res. Dev. 201923,1587-1593 (Invited paper)


        4)Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with    

              Amines

              Xia Wang, Qiu-Xia Yang, Cheng-Yu Long, Yan Tan, Yi-Xin Qu, Min-Hui Su, Weihong Tan*, Xue-Qiang Wang*

               Org. Lett. 2019, 21, 5111-5115.


2018年


         3)Nucleophilic Amination and Etherification of Aryl Alkyl Thioethers

               Xia Wang, Yue Tang, Cheng-Yu Long, Wen-Ke Dong, Chenchen Li, Xinhua Xu, Wanxiang Zhao,* Xue-Qiang Wang*

               Org. Lett. 2018, 20, 4749–4753.

            Highlighted by Synfacts 2018, 14(10), 1076

         

        2)  Metal-Free Etherification of Aryl Methyl Ether Derivatives by C-OMe Bond Cleavage

             Xue-Qiang Wang,* Chenchen Li, Xia Wang, Qingli Wang, Xiu-Qin Dong, Abing Duan,* Wanxiang Zhao*
               Org. Lett. 2018, 20, 4267–4272.


          1)NaI-mediated Divergent Synthesis of Isatins and Isoindigoes: A New Protocol Enabled by Oxidation Relay Strategy
              Hong-hua Zhang, Yong-qiang Wang, Long-tao Huang, Long-qing Zhu, Yi-yue Feng, Yingmei Lu, Quan-yi Zhao,

              Xue-Qiang Wang,* Zhen Wang *

              Chem. Commun., 2018, 54, 8265-8268.

 

求学期间代表性论文

1)  Ni-Catalyzed Regioselective Hydroamidation of Alkynes with Isocyanates Using Simple Alkyl Bromide as Hydride Source

      Wang, X.; Nakajima, M.; Serrano, E.; Martin, R. J. Am. Chem. Soc. 2016, 138, 15531.

      Among Most read JACS articles in December 2016

2)    Ni-Catalyzed Regioselective Hydrocarboxylation of Alkynes with CO2 by Using Simple Alcohols as Proton Sources

      Wang, X.; Nakajima, M.; Martin, R. J. Am. Chem. Soc. 2015, 137, 8924.

Ÿ      Most read JACS articles in July 2015

3)     Ni-catalyzed Divergent Cyclization/Carboxylation of Unactivated Primary and Secondary Alkyl Halides with CO2

     Wang, X.(co-first author); Liu, Y.; Martin, R. J. Am. Chem. Soc. 2015, 137, 6476.

Ÿ      Among the most read JACS articles in May 2015

4)    Mild ArI-Catalyzed C(sp2)-H or C(sp3)-H Functionalization/C-O Formation: Intriguing Catalyst-Controlled Selectivity Switch.

      Wang, X.; Gallardo-Donaire, J.; Martin, R. Angew. Chem. Int. Ed. 2014, 53, 11084.

Ÿ      Highlighted in Synfacts 2014, 10 (12), 1255

5)    Enantioselective Electrophilic Trifluoromethylthiolation of β-Ketoesters: A Case of Reactivity and Selectivity Bias for

     Organocatalysis.

     Wang, X.(co-first author); Yang, T.; Cheng, X.; Shen, Q. Angew. Chem. Int. Ed. 2013, 52, 12860.



奖励与荣誉

2019入选“湖湘青年英才”计划

2015国家优秀自费留学生奖学金

2015西班牙优秀博士论文

2015礼来公司(欧洲)优秀博士毕业生

2007山东省优秀毕业生