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葛行义

发布于:2018-10-18 星期四 12:29:16 点击数:4349

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葛行义

教授、博士生导师

Tel:13659882712

E-mail:xyge@hnu.edu.cn


基本信息

任职于湖南大学生物学院,主要研究方向为动物新型病毒病原发现与鉴定、重要病毒病原如冠状病毒、汉坦病毒等的种间传播、感染和致病机制等。

在SARS冠状病毒溯源、动物病毒宏基因组学研究等方面取得良好进展,在Nature、JVI、JGV等杂志发表SCI论文30余篇,参与专著编写2部。 获得湖北省优秀学术论文-特等奖一项、 湖北省自然科学奖一等奖一项(排名第二)、“梅里埃青年优秀论文奖-三等奖” 、中国科学院优秀博士学位论文、中国科学院院长优秀奖等奖项。主持国家自然科学基金2项、2017年入选湖南省 “湖湘青年英才”人才计划、2019年获“湖南省杰青”人才项目。


招聘信息:

由于课题研究与项目研发的需要,本实验室正在招聘:

1、课题组副组长(Co-PI);

2、特聘研究岗位(研究员、副研究员、助理研究员与研究助理);

3、招聘博士后;

4、每年招收博士与硕士研究生。

有意者请联系并将个人简历发送至 xyge@hnu.edu.cn邮箱。


教育背景

2001-2005华中农业大学生物技术专业本科;

2005-2008华中农业大学预防兽医学硕士;

2008-2011中国科学院武汉病毒研究所生化与分子生物学博士;

2010法国巴斯德研究所中法联合培养博士生项目。






工作履历

2016.6至今任湖南大学生物学院教授、博士生导师;

2013.9-2016.5任国科学院武汉病毒研究所副研究员;

2012.1-2013.8任国科学院武汉病毒研究所助理研究员。


研究领域

动物新型病毒病原发现与鉴定、病毒生物信息学、重要病毒病原如冠状病毒、汉坦病毒等的种间传播、感染和致病机制等。

科研项目

1.    2019年度湖南省杰出青年项目(负责人) 

2.    2018-2020, 国家重点研发计划(子课题负责人);

3.        2018-2020, 国家重点研发计划(子课题负责人);

4.        2017-2019,“湖湘青年英才”人才项目负责人

5.        2015-2018, 国家自然科学基金面上项目(负责人);

6.        2015-2017, 国家自然科学基金青年项目(负责人)。


学术成果

1.        Ge XY, Li JL, Yang XL, Chmura AA, Zhu G, Epstein JH, Mazet JK, Hu B, Zhang W, Peng C, Zhang YJ, Luo CM, Tan B, Wang N, Zhu Y, Crameri G, Zhang SY, Wang LF, Daszak P, Shi ZL. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013 Nov 28;503(7477):535-8. doi: 10.1038/nature12711.

2.        Ge XY, Yang WH, Zhou JH, Li B, Zhang W, Shi ZL, Zhang YZ. Detection of alpha- and betacoronaviruses in rodents from Yunnan, China. Virol J. 2017 May 26;14(1):98.

3.        Ge XY, Wang N, Zhang W, Hu B, Li B, Zhang YZ, Zhou JH, Luo CM, Yang XL, Wu LJ, Wang B, Zhang Y, Li ZX, Shi ZL. Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft. Virol Sin. 2016 Feb;31(1):31-40.

4.        Ge XY, Yang WH, Pan H, Zhou JH, Han X, Zhu GJ, Desmond JS, Daszak P, Shi ZL, Zhang YZ. Fugong virus, a novel hantavirus harbored by the small oriental vole (Eothenomys eleusis) in China. Virol J. 2016 Feb 16;13:27. doi:10.1186/s12985-016-0483-9. Erratum in: Virol J. 2016;13(1):75.

5.        Xing-Yi Ge, Ben Hu, and Zheng-Li. Chapter 5: Bat coronaviruses, p127-148. Bats and Viruses: From Pathogen Discovery to Host Genomics. Lin-fa Wang, 2015, Wiley-Blackwell. ISBN: 9781118818732. Published Online: 26 JUN 2015, DOI: 10.1002/9781118818824.ch5.

6.        Ge X, Wu Y, Wang M, Wang J, Wu L, Yang X, Zhang Y, Shi Z. Viral metagenomics  analysis of planktonic viruses in East Lake, Wuhan, China. Virol Sin. 2013 Oct;28(5):280-90.

7.        Ge X, Li Y, Yang X, Zhang H, Zhou P, Zhang Y, Shi Z. Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in China. J Virol. 2012 Apr;86(8):4620-30.

8.        Ge X, Rameix-Welti MA, Gault E, Chase G, dos Santos Afonso E, Picard D, Schwemmle M, Naffakh N. Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response. PLoS One. 2011;6(8):e23368. doi: 10.1371/journal.pone.0023368.

9.        Ge X, Li J, Peng C, Wu L, Yang X, Wu Y, Zhang Y, Shi Z. Genetic diversity of novel circular ssDNA viruses in bats in China. J Gen Virol. 2011 Nov;92(Pt 11):2646-53.

10.    Li TT, Li JY, Huang T, Ge XY. Complete Genome Sequence of a Novel Strain of Infectious Bronchitis Virus, Isolated from Chickens in China in 2016. Genome Announc. 2017 Nov 9;5(45). pii: e01277-17. doi: 10.1128/genomeA.01277-17.

11.    Zeng Z, Li TT, Jin X, Peng FH, Song NH, Peng GQ, Ge XY. Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016. Virol Sin. 2017 Aug;32(4):298-306.

12.    Wang N, Ruan Z, Wan Y, Wang B, Zhang SH, Ge XY. Identification of a novel strain of influenza A (H9N2) virus in chicken. Virol Sin. 2015 Aug;30(4):309-12. doi: 10.1007/s12250-015-3616-1. PubMed PMID: 26242377.

13.    Zhang Z, Zhu Z, Chen W, Cai Z, Xu B, Tan Z, Wu A, Ge X, Guo X, Tan Z, Xia Z, Zhu H, Jiang T, Peng Y. Cell membrane proteins with high N-glycosylation, high expression, and multiple interaction partners are preferred by mammalian viruses  as receptors. Bioinformatics. 2018 Aug 9. doi: 10.1093/bioinformatics/bty694.

14.    Zhu Z, Zhang Z, Chen W, Cai Z, Ge X, Zhu H, Jiang T, Tan W, Peng Y. Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein. Infect Genet Evol. 2018 Jul;61:183-184.

15.    Hu B, Zeng LP, Yang XL, Ge XY, Zhang W, Li B, Xie JZ, Shen XR, Zhang YZ, Wang N, Luo DS, Zheng XS, Wang MN, Daszak P, Wang LF, Cui J, Shi ZL. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog. 2017 Nov 30;13(11):e1006698.

16.    Zeng LP, Ge XY, Peng C, Tai W, Jiang S, Du L, Shi ZL. Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses. Sci China Life Sci. 2017 Dec;60(12):1399-1402.

17.    Zhu Y, Mao C, Ge X, Wang Z, Lu P, Zhang Y, Chen S, Hu Y. Characterization of a Minimal Type of Promoter Containing the -10 Element and a Guanine at the -14 or -13 Position in Mycobacteria. J Bacteriol. 2017 Oct 3;199(21). pii: e00385-17.

18.    Tan B, Yang XL, Ge XY, Peng C, Liu HZ, Zhang YZ, Zhang LB, Shi ZL. Novel bat adenoviruses with low G+C content shed new light on the evolution of adenoviruses. J Gen Virol. 2017 Apr;98(4):739-748. doi: 10.1099/jgv.0.000739. PubMed PMID: 28475035.

19.    Waruhiu C, Ommeh S, Obanda V, Agwanda B, Gakuya F, Ge XY, Yang XL, Wu LJ, Zohaib A, Hu B, Shi ZL. Molecular detection of viruses in Kenyan bats and discovery of novel astroviruses, caliciviruses and rotaviruses. Virol Sin. 2017 Apr;32(2):101-114. doi: 10.1007/s12250-016-3930-2. Epub 2017 Apr 6. PubMed PMID: 28393313.

20.    Wang B, Yang XL, Li W, Zhu Y, Ge XY, Zhang LB, Zhang YZ, Bock CT, Shi ZL. Detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in China. Virol J. 2017 Feb 22;14(1):40. doi: 10.1186/s12985-017-0706-8. PubMed PMID: 28222808; PubMed Central PMCID: PMC5320732.

21.    Wang SR, Zhang QY, Wang JQ, Ge XY, Song YY, Wang YF, Li XD, Fu BS, Xu GH, Shu B, Gong P, Zhang B, Tian T, Zhou X. Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene. Cell Chem Biol. 2016 Sep 22;23(9):1113-1122. doi:10.1016/j.chembiol.2016.07.019. PubMed PMID: 27617851.

22.    Zeng LP, Gao YT, Ge XY, Zhang Q, Peng C, Yang XL, Tan B, Chen J, Chmura AA, Daszak P, Shi ZL. Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. J Virol. 2016 Jun 24;90(14):6573-6582. doi: 10.1128/JVI.03079-15. Print 2016 Jul 15. PubMed PMID: 27170748; PubMed Central PMCID: PMC4936131.

23.    Tan B, Yang XL, Ge XY, Peng C, Zhang YZ, Zhang LB, Shi ZL. Novel bat adenoviruses with an extremely large E3 gene. J Gen Virol. 2016 Jul;97(7):1625-35.

24.    Wang MN, Zhang W, Gao YT, Hu B, Ge XY, Yang XL, Zhang YZ, Shi ZL. Longitudinal surveillance of SARS-like coronaviruses in bats by quantitative real-time PCR. Virol Sin. 2016 Feb;31(1):78-80.

25.    Yang XL, Hu B, Wang B, Wang MN, Zhang Q, Zhang W, Wu LJ, Ge XY, Zhang YZ, Daszak P, Wang LF, Shi ZL. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. J Virol. 2015 Dec 30;90(6):3253-6.

26.    Hu B, Ge X, Wang LF, Shi Z. Bat origin of human coronaviruses. Virol J. 2015 Dec 22;12:221.

27.    Liang YZ, Wu LJ, Zhang Q, Zhou P, Wang MN, Yang XL, Ge XY, Wang LF, Shi ZL. Cloning, expression, and antiviral activity of interferon β from the Chinese microbat, Myotis davidii. Virol Sin. 2015 Dec;30(6):425-32.

28.    Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015 Dec;21(12):1508-13.

29.    Yang XL, Tan B, Wang B, Li W, Wang N, Luo CM, Wang MN, Zhang W, Li B, Peng C, Ge XY, Zhang LB, Shi ZL. Isolation and identification of bat viruses closely related to human, porcine and mink orthoreoviruses. J Gen Virol. 2015 Dec;96(12):3525-31.

30.    Wang MN, Ge XY, Wu YQ, Yang XL, Tan B, Zhang YJ, Shi ZL. Genetic diversity and temporal dynamics of phytoplankton viruses in East Lake, China. Virol Sin. 2015 Aug;30(4):290-300.

31.    Wang Y, Sun Y, Wu A, Xu S, Pan R, Zeng C, Jin X, Ge X, Shi Z, Ahola T, Chen Y, Guo D. Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis. J Virol. 2015 Aug;89(16):8416-27. doi: 10.1128/JVI.00948-15.

32.    Xia H, Wang M, Ge X, Wu Y, Yang X, Zhang Y, Li T, Shi Z. Study of the dynamics of Microcystis aeruginosa and its cyanophage in East Lake using quantitative PCR. Virol Sin. 2013 Oct;28(5):309-11.

33.    Wu L, Zhou P, Ge X, Wang LF, Baker ML, Shi Z. Deep RNA sequencing reveals complex transcriptional landscape of a bat adenovirus. J Virol. 2013 Jan;87(1):503-11. .

34.    Moisy D, Avilov SV, Jacob Y, Laoide BM, Ge X, Baudin F, Naffakh N, Jestin JL. HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. J Virol. 2012 Sep;86(17):9122-33.

35.    Yang X, Zhang Y, Ge X, Yuan J, Shi Z. A novel totivirus-like virus isolated from bat guano. Arch Virol. 2012 Jun;157(6):1093-9.

36.    Li Y, Ge X, Hon CC, Zhang H, Zhou P, Zhang Y, Wu Y, Wang LF, Shi Z. Prevalence and genetic diversity of adeno-associated viruses in bats from China. J Gen Virol. 2010 Oct;91(Pt 10):2601-9.

37.    Zhang Y, Zhang H, Dong X, Yuan J, Zhang H, Yang X, Zhou P, Ge X, Li Y, Wang LF, Shi Z. Hantavirus outbreak associated with laboratory rats in Yunnan, China.  Infect Genet Evol. 2010 Jul;10(5):638-44.

38.    Li Y, Ge X, Zhang H, Zhou P, Zhu Y, Zhang Y, Yuan J, Wang LF, Shi Z. Host range, prevalence, and genetic diversity of adenoviruses in bats. J Virol. 2010 Apr;84(8):3889-97. doi: 10.1128/JVI.02497-09.


奖励与荣誉

湖北省优秀学术论文-特等奖一项

湖北省自然科学奖一等奖一项(排名第二)

“梅里埃青年优秀论文奖-三等奖” 

中国科学院优秀博士学位论文

中国科学院院长优秀奖等奖项

2017年入选湖南省 “湖湘青年英才”人才计划

2018年获“国家自然科学奖-二等奖”(排名第二)

2019年获“湖南省杰出青年”人才项目