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李家昆

发布于:2019-11-07 星期四 17:41:17 点击数:4488

教授、博士生导师

Email: jkli@hnu.edu.cn

基本信息

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李家昆,湖南大学化学化工学院、化学生物传感与计量学国家重点实验室教授、博士生导师。主要从事生物活性分子导向的有机氟合成方法学,新型糖苷化方法、复杂寡糖的全合成及构效关系等领域的研究。

欢迎报考本实验室博士研究生、硕士研究生,随时欢迎联合培养学生、本科生入组。课题组长期招聘副教授(编制内)、讲师(编制内)、博士后。


教育背景

2009.09–2014.06    中国科学技术大学-中科院上海有机所联合培养,理学博士,导师:俞飚研究员 

2005.09–2009.07    黑龙江大学,理学学士, 导师:马东升教授


工作履历

2019.09–至今          湖南大学化学化工学院 教授,博士生导师

2015.05–2019.06    德国马普煤炭所(MPI für Kohlenforschung)、哈佛大学, 博士后,导师:Tobias Ritter教授

2014.07–2015.04    中国科学院上海有机化学研究所,助理研究员, 导师:俞飚研究员

研究领域

1. 新型有机氟代反应

2. 具有重要生理活性的糖及糖缀合物的合成方法学、全合成和化学生物学

3. 18F-PET分子影像探针的合成及临床应用


学术成果

迄今发表国际期刊文章10篇,以第一/共同第一作者在Nature, Nature Chemistry, J. Am. Chem. Soc., Angew. Chem. Int. Ed.等国际权威期刊发表论文6篇。研究成果被C&EN、BioCentury及F1000Prime等专题报道。

1. Jiakun Li, Junting Chen, Ruocheng Sang, Won-Seok Ham, Matthew B. Plutschack, Florian Berger, Sonia Chabbra, Alexander Schnegg, Christophe Genicot and Tobias Ritter*. “Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination” Nature Chemistry, 2020, 12, 56-62.

2. Junting Chen, Jiakun Li, Matthew B. Plutschack, Florian Berger and Tobias Ritter*. “Regio- and Stereoselective Thianthrenation of Olefins to Access Versatile Alkenyl Electrophiles” Angew. Chem. Int. Ed. 2020, 59, 5616-5620.

3. Kumiko Yamamoto#, Jiakun Li#, Jeffrey A. O. Garber, Julian D. Rolfes, Gregory B. Boursalian, Jannik C. Borghs, Christophe Genicot, Jérôme Jacq, Maurice van Gastel, Frank Neese and Tobias Ritter*. “Palladium-catalysed electrophilic aromatic C–H fluorination” Nature, 2018, 554, 511–514 (#equal contribution).

4. Neil P.J. Price*, Trina M. Hartman, Jiakun Li, Kiran K. Velpula, Todd A. Naumann, Biao Yu, Kenneth M. Bischoff. “Modified Tunicamycins with Reduced Toxicity that Enhance the Antibacterial Activity of β-Lactams.” The Journal of Antibiotics, 2017, 70, 1070–1077.

5. Neil P.J. Price*, Michael A Jackson, Karl E Vermillion, Judith A Blackburn, Jiakun Li and Biao Yu. “Selective catalytic hydrogenation of the N-acyl and uridyl double bonds in the tunicamycin family of protein N-glycosylation inhibitors” The Journal of Antibiotics, 2017, 70, 1122–1128.

6. Nathaniel W. Goldberg, Xiao Shen, Jiakun Li and Tobias Ritter* “AlkylFluor: Deoxyfluorination of Alcohols” Org. Lett. 2016, 18, 6102–6104.

7. Jiakun Li and Biao Yu*. “A Modular Approach to the Total Synthesis of Tunicamycins” Angew. Chem. Int. Ed. 2015, 54, 6618–6621.

8. Jiakun Li, Yuanwei Dai, Laval Stéphane, Wei Li, Peng Xu and Biao Yu*. “Effective Synthesis of α-D-GlcN-(1®4)-D-GlcA/L-IdoA Glycosidic Linkage under Gold(I) Catalysis” The Asian Journal of Organic Chemistry, 2015, 4, 756–762.

9. Yu Tang#, Jiakun Li#, Yugen Zhu, Yao Li and Biao Yu*. “Mechanistic Insights into the Gold(I)-Catalyzed Activation of Glycosyl ortho-Alkynylbenzoates for Glycosidation” J. Am. Chem. Soc. 2013, 135, 18396–18405 (#equal contribution).

10. Jiakun Li, Wei Li* and Biao Yu*. “A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction” Org. Biomol. Chem. 2013, 11, 4971–4974.


奖励与荣誉

2019.12 湖南省百人计划(青年)