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刘斌

发布于:2018-10-17 星期三 18:24:09  点击数:30607

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刘斌

博士、留美博士后、教授、硕士研究生导师、博士后合作导师

Tel:13508481556

E-mail:binliu2001@hotmail.com

 

基本信息

1994年毕业于湖南师范大学生物系,2001年于中南大学肿瘤研究所获硕士学位,研究方向为鼻咽癌发病分子机制;2002年至2007年在湖南大学攻读博士学位,研究方向为纳米荧光探针与肿瘤生化分析,2007年9月赴美国Texas Tech University医学院开展博士后研究,研究内容为肾类疾病分子机制。目前研究方向主要集中在药用植物活性成分群的靶向筛选、抗肿瘤、心血管疾病的天然药物靶向递送和抗感染复合纳米材料研究。先后主持和参与各类科研项目20多项,指导博士后3名,联合指导博士研究生12名,指导硕士研究生40多名,毕业硕士研究生20多人,指导学生先后50多人次获国家奖学金、校、院优秀研究生、优秀共产党员等荣誉称号。以第一和通讯作者身份在Biomaterials、Acta Biomaterialia、Anal chem、Biosensor and Bioelectrics等国际知名学术期刊发表论文100来篇,总影响因子达到240,论文他引2000多次。

教育背景

1994年毕业于湖南师范大学生物系

2001年于中南大学肿瘤研究所获硕士学位

2002年至2007年在湖南大学攻读博士学位

2007至2009在美国Texas Tech大学开展博士后研究



工作履历

2001.7-至今: 湖南大学生物学院

学术兼职

目前担任中国民族医药协会委员、湖南中医药大学中药民族药创新发展实验室学术委员会委员。

研究领域

研究方向主要集中在天然药物化学与二维碳材料在生物医学中的应用

研究内容主要包括:(1)基于新型纳米材料的多模式抗肿瘤体系的构建;(2)损伤修复酶活性分析方法构建与效应剂的高通量筛选;(3)民族药用植物天然成分的分离、鉴定与活性研究。



科研项目

主持和参与科研项目

[1] 丙型肝炎病毒在干扰素耐药和胰岛素抵抗中的作用机制, 国家自然科学基金70万,参与

[2] 黄精标准化建设项目, 国家中医药管理局,10万,主持

[3]农业部麻类生物学与加工重点实验室2018年度开放课题资助项目, 6万,主持

[4]湖南省妇幼保健院联合研发项目,10万,主持

[5]叶酸-壳聚糖-盐酸米托蒽醌纳米颗粒靶向治疗鼻咽癌的研究,东莞市科技局资助,7万,主持

[6]新型分子信标的设计及其在损伤修复研究中的应用, 中央高校科研业务费20万,主持

[7]5-氟尿嘧 /硒复合纳米缓释制剂的创制及其作用机制研究, 湖南省自然科学基金4万,参与

[8]生物纳米技术用于恶性肿瘤侵袭和转移的分子机理研究, 973计划 ,300, 参与

[9] 超灵敏检测microRNA的双重信号放大系统构建及其在肝癌诊断中的应用研究湖南省自然科学基金面上项目4万,主持

[10] 基于分子识体的细胞识别和未知蛋白捕获研究, 湖南省科技厅重点项目,20万,参与  

[11] 生物纳米技术用于恶性肿瘤早期诊断的基础研究 科技部国际合作项目120万,参与

[12] 肿瘤相关基因转录产物的痕量分析及其在活细胞内的成像研究, 国家自然科学基金20万,参与。

[13]负载黄酮J5的仿生化纳米药物联合光热治疗抗乳腺癌研究,湖南省科技厅面上项目,10万,主持

[14]盐酸青藤碱纳米靶向递送制剂研究,湖南中医药大学联合项目, 20万,主持

[15]工具酶激活剂筛选与应用研究,湖南艾科瑞生物工程有限公司联合项目,50万,主持





学术成果

近年发表的部分文章:

[1] Y Qin, C Peng, W Yang, et al. A bi-functional fluorescent probe for visualized and rapid natural drug  screening via GSTs activity monitoring. Sensors and Actuators B: Chemical 328(2021) :129047. (IF: 7.100)

[2]  X Xiong, W Dang, R Luo, et al. A graphene-based fluorescent nanoprobe for simultaneous imaging of dual miRNAs in living cells Talanta 225(2021) 121947 (IF:5.339)

[3] Z Wang, Y Long, J Fan, et al. Biosafety and biocompatibility assessment ofPrussian blue nanoparticles in vitro and invivo. Nanomedicine 2020 (IF: 4.83).

[4] C Tong, X Zhong, Y Yang, et al. PB@PDA@Ag nanosystem for synergistically eradicating MRSA andaccelerating diabetic wound healing assisted with laser irradiation. Biomaterials 243 (2020) 119936 (IF:10.273)

[5] Y Qiu,W Dang, J Fan, et al. DNAzyme and rGO based fluorescence assay for Fpg activity analysis, drug screening, and bacterial imaging. Talanta 218 (2020) 121158 (IF5.339)

[6] Y Qin, J Fan, W Yang, et al. Endogenous Cys-Assisted GSH@AgNCs-rGO Nanoprobe for Real Time Monitoring of Dynamic Change in GSH Levels Regulated by Natural Drug. Anal Chem 92( 2020) 1988-1996 (IF: 6.32)

[7] T Zhou, R Luo, Y Li, B Liu, et al. Activity assay and intracellular imaging of APE1 assisted with tetrahedralDNA nano structure modified-dnazyme and molecular beacon. Sensors & Actuators: B. Chemical 317 (2020) 128203 (IF: 7.100).

[8] L Luo, F Zeng, J Xie, et al. A RBC membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photother mal therapy of cervical cancer. J. Mater. Chem. B, 8(2020) 4080 (IF:5.344)

[9] M Daniyal, Y Jian, F Xiao, et al. Development of a nanodrug-delivery systemcamouflaged by erythrocytes membrane for the chemo/phototherapy of cancer. Nanomedicine 2020 (IF: 4.83).

[10] J Fan, Bin Liu, Y Long, et al. Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. Acta Biomaterialia. 113(2020): 554-569 (IF:7.36)

[11] C Tong C, Y Hu , Q Xie, et al. Sensitive RNase A detection and intracellular imaging using a natural compound-assisted tetrahedral DNA nanoprobe. Chem Comm. 2020 DOI: 10.1039/ d0cc 00284d (IF: 6.23)

[12] R Luo, H Zhou, W Dang, et al. A DNAzyme-rGO coupled fluorescence assay for T4PNK activity in vitro andintracellular imaging. Sensors and Actuators B: Chemical  310(2020):127884. (IF: 7.100)

[13] Y Long, X Wu, Z Li, et al. PEGylated WS2 nanodrug system with erythrocyte membrane coating for chemo/photothermal therapy of cervical cancer. Biomaterials Science 8(2020) 5088

[14] B Liu ,W Wang, J Fan, et al. RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer. Biomaterials 2019, 217:119301 (IF:10.273)

[15] C Tong, L Li, F Xiao, J Fan,et al. Daptomycin and AgNP co-loaded rGO nanocomposites for specific treatment of Gram-positive bacterial infection in vitro and in vivo. Biomaterials Science DOI: 10.1039/c9bm01229j (IF:5.31)

[16] H Zhou, C Tong, W Zou, et al. A novel fluorescence method for activity assay and drug screening of T4 PNK by coupling rGO with ligase reaction. Analyst 2019, 11:1187-1196 ( IF:3.864)

[17] S Tasneem, B Liu, Bin Li, et al. Molecular pharmacology of inflammation: medicinal plants as antiinflammatory agents. Pharmacological Research, 2019, 139:126-140 ( IF: 4.897)

[18] W Wang, J Li,J Fan, et al. Ultrasensitive and non-labeling fluorescence assay for biothiols using enhanced silver nanoclusters. Sensors and Actuators B: Chemical 2018, 267:174-180 (IF:5.667)

[19] Y Qin, M Danial, W Wang, et al. An Enhanced Silver Nanocluster System for Cytochrome c Detection and Natural Drug Screening targeted for Cytochrome c. Sensors and Actuators B: Chemical 2019,291:485-492 (IF:5.667)

[20]  C Tong, X Zhang, J Fan, et al. PEGylated mBPEI-rGO nanocomposites facilitate hepotocarcinoma treatment combining photothermal therapy and chemotherapy. Science Bulletin 2018, 63(14): 935-946.

[21]  Y Chen, N Liang, J Fan, et al. Seco-dammarane triterpenoids from the leaves of Cyclocarya paliurus Phytochem istry  2018,145: 85-92 (IF:3.186).

[22] C Tong, C Zhao, Bin Liu, et al. Sensitive detection of RNase A activity and collaborative drugs screening based on rGO and fluorescence probe. Anal Chem.2018,  90(4): 2655-2661. (IF: 6.32)

[23] J Li, X Zhang, J Jiang, et al. Systematic Assessment of the Toxicity and Potential Mechanism of Graphene Derivatives In Vitro and In Vivo. Toxicological Sciences, 2018, https://doi.org/10.1093/ toxsci/kfy235.(IF: 4.181)

[24] C Zhao, J Fan, L Peng, et al. An end-point method based on graphene oxide for RNase H analysis and inhibitors screen. Biosens  Bioelectron  2017, 90: 103-109 (IF:7.78)

[25] L Wang, H Zhou, B Liu, et al. Fluorescence Assay for Ribonuclease H Based on Nonlabeled Substrate and DNAzyme Assisted Cascade Amplification. Anal Chem. 2017, 89: 11010-11020  (IF: 6.32)

[26] L Peng, J Fan, C Tong, et al. An ultra sensitive fluorescence method suitable for quantitative analysis of mung bean nuclease and inhibitor screening in vitro and vivo. Biosens Bioelectron  2016, 83: 169-176 (IF: 7.457)

[27] W Xu, Z Xie, C Tong , et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO- quenched hairpin probe. Anal Bioanal Chem 2016,14: 3801- 3809. (IF:3.45)

[28] B Liu, L Peng. Real-time monitoring AP site incision caused by APE1 using a modified hybridization probe. Anal. Methods  2016,8: 862-868 (IF:1.92)

[29] W Xu, L Peng, B Li, et al. A real time S1 assay at neutral pH based on graphene oxide quenched fluorescence probe.  Sensing and Bio-Sensing Research 7(2016) 42- 47

[30] C Li, Y Long, B Liu, et al. Real time monitoring uracil excision using uracil- containing molecular beacons. Anal Chimica Acta 8(2014)1104-1108IF4.57)

[31]  B Liu, D Xiang, Y Long, et al. Real time monitoring of junction ribonuclease activity of RNase H using chimeric molecular beacons. Analyst 138(2013) 3238–3245 (IF4.033)

[32] N Liu, Y Long, B Liu, et al. ISG12a mediates cell response to Newcastle disease viral infection. Virology 462-463(2014) 283-294 (IF:3.200)

[33]  B Liu, W Wang, C Li, et al. A rapid and simple method to assess the changes of human VEGF mRNA based on dual molecular beacons. Anal Methods 13 (2014) 4585- 4592 (IF:1.915)

[34] B Liu, C Li, et al. Increasing extracellular matrix collagen level and MMP activity induces cyst development in polycystic kidney disease. BMC Nephrology 2012,13: 109 doi: 10.186/ 1471- 2369-13-109.