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孙宏羽

发布于:2018-10-18 星期四 21:09:00 点击数:3977

孙宏羽.png   孙宏羽

  教授,博士生导师

 Tel: 18670390670

  Email:S5893149@hnu.edu.cn


基本信息

1980年出生于中国台湾,2011年毕业于台湾成功大学基础医学研究所,获得理学博士学位。2012年--2018年于台湾成功大学医学检验及生物科技学系从事博士后研究,2018年担任台湾成功大学兼任助理教授,同年被聘为湖南大学教授、博士生导师。2013年获颁台湾科技部博士后研究人员学术著作奖,207年获颁台湾肝病防治学术基金会肝病防治优秀论文奖。参与台湾科技部及产学研合作多项专题研究计划,2017年作为CO-PI主持台湾成功大学/秀传医疗体系合作计划。研究工作作为探讨载脂蛋白调控胞内/外脂肪积累之分子机制,于肝炎病毒,代谢性疾病及细胞癌化之应用,以第一作者及共同作者在刊“GUT”及“Journal of hepatology”等杂志发表十余篇论文,担任Journal of On cology之客座编辑。

教育背景

博士国立成功大学        基础医学研究所       2004/9~2011/6

硕士国立成功大学        分子医学研究所       2002/9~2004/6

学士国立中兴大学           动物系          1998/9~2002/6

工作履历

2018/09-今      湖南大学生物医学工程学系             教授

 2018/09-今      台湾成功大学分子医学研究所         兼任助理教授

 2011/08-2018/09   台湾成功大学医学检验生物技术学系     博士后研究员

 2016/11-2016/12   加拿大渥太华生物及微生物免疫学系     访问博士后研究员

研究领域

主要从事脂蛋白/载脂蛋白代谢,肝炎病毒学,细胞生物学,分子病毒学及微生物致病机转领域的科研工作。长期研究目标为探讨载脂蛋白及脂蛋白调控胞内/外脂肪累积之分子机制,于肝炎病毒,代谢性疾病及细胞癌化之应用,具体工作目标包括载脂蛋白于脂肪酸及病毒诱发脂肪累积之机制,载脂蛋白于代谢相关疾病临床显着性,构筑代谢相关疾病之载脂蛋白与脂肪体数据库及寻找能够预防或治疗脂肪累积之小分子药物。

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学术成果

1. Yu-Min Lin, Hung-Yu Sun, Wen-Tai Chiu, Hui-Chen Su, Yu-Chieh Chien,Lee-Won Chong, Hung-Chuen Chang, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao. Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation. Viruses, 2018 (Impact Factor 3.761)

2. Hung-Yu Sun*, Pin-Nan Cheng, Chiung-Ying Tseng, Wei-Jen Tsai, Yen-Cheng Chiu, Kung-Chia Young. Favoring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic hepatitis C virus infection. GUT, 2018. 67:1342-1350 (Impact Factor 17.016)

3. Peiju Tsai, Chun-Chieh Lin, Hung-Yu Sun, Jin-Ching Lee, Ting-Tsung Chang, Kung-Chia Young. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient’s viremia. Journal of Microbiology, Immunology and Infection. 2018. 51:446-455. (Impact Factor 2.094)

4. Hung-Yu Sun*, Chun-Chieh Lin, Pei-Ju Tsai, Wei-Jen Tsai, Jin-Ching Lee, Chiung-Wen Tsao, Pin-Nan Cheng, I-Chin Wu, Yen-Cheng Chiu, Ting-Tsung Chang, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cellular Microbiology, 2017. 19: e12673. (Impact Factor 4.41)

5. Yu-Min Lin, Bu-Chin Yu, Wen-Tai Chiu, Hung-Yu Sun, Yu-Chieh Chien, Hui-Chen Su, Shu-Yang Yen, Hsin-Wen Lai, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao. Fluoxetine regulates cell growth inhibition of interferon-&alpha. International Journal of Oncology, 2016. 49:1746-54. (Impact Factor 3.333)

6. Cheng-Hsun Ho, Huai-Chia Chuang, I-Chin Wu, Hung-Wen Tsai, Yih-Jyh Lin, Hung-Yu Sun, Kung-Chia Young, Yen-Cheng Chiu, Pin-Nan Cheng, Wen-Chun Liu, Tse-Hua Tan, Ting-Tsung Chang. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget, 2016. 7: 49765-49776

7. Chun-Chieh Lin, Peiju Tsai, Hung-Yu Sun, Mei-Chi Hsu, Jin-Ching Lee, I-Chin Wu, Chiung-Wen Tsao, Ting-Tsung Chang, Kung-Chia Young. Apolipoprotein J, a glucose up-regulated molecular chaperone stabilizes core and NS5A to promote infectious hepatitis C virus virion production, Journal of Hepatology, 2014; 61: 984-93. (Impact Factor 12.486)

8. Jin-Ching Lee, Chin-Kai Tseng, Kung-Chia Young, Hung-Yu Sun, Shainn-Wei Wang, Wei-Chun Chen, Chun-Kuang Lin, Yu-Hsuan Wu. Andrographolide exerts anti-hepatitis C virus activity by upregulating heme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. BRITISH JOURNAL OF PHARMACOLOGY, 2014; 171: 237-252. (Impact Factor 6.81)

9. Hung-Yu Sun*, Chun-Chieh Lin, Jin-Ching Lee, Shainn-Wei Wang, Pin-Nan Cheng, I-Chin Wu, Ting-Tsung Chang, Ming-Derg Lai, Dar-Bin Shieh, Kung-Chia Young. Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. GUT, 2013; 62:1193-1203. (Impact Factor 17.016)

10. Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin and Kung-Chia Young. The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in taiwanese breast cancer patients: a 10-year follow-up study. BMC CANCER, 2013; 13:330. (Impact Factor 3.288)

11. M-C Hsu, C-S Chang, K-T Lee, H-Y Sun, Y-S Tsai, P-H Kuo, K-C Young and CH Wu. Central obesity in males affected by a dyslipidemia associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster. Nutrition & Diabetes, 2013; 3: e06. (Impact Factor 3.534)

12. Sun HY*, Ou NY, Wang SW, Liu WC, Cheng TF, Shr SJ, Sun KT, Chang TT, Young KC (2011) Novel Nucleotide and Amino Acid Covariation between the 5'UTR and the NS2/NS3 proteins of Hepatitis C Virus: Bioinformatic and Functional Analyses. PLoS One. 6: e25530 (Impact Factor 2.806)

13. Sun HY*, Chen SF, Lai MD, Chang TT, Chen TL, Li PY, Shieh DB, Young KC (2010) Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clin Chim Acta 411: 336-344. (Impact Factor 2.873)


国际研讨会论文 (2013-2018)

1.      Chiung-Wen Tsao, Yu-Min Lin, Hung-Yu Sun, Kung-Chia Young, Yu-Chieh Chien, Wu-Tzu Feng. Anti-HCV effect of calcitriol via the newly protein synthesis and blockade of PPAR-g activity. 6th International Symposium on Infectious Disease and Signal Transduction/2016 Tawain-Japan Joint Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan (R.O.C), 2016 Oct 22-23.

2.      Hung Yu Sun, Kung Chia Young. Lipoprotein lipase inhibits hepatitis C virus infection and reverses virus induced lipid accumulation through unsaturated fatty acid/CD36/PPARalpha signaling pathway. 23rd International Symposium on Hepatitis C Virus and Related Viruses. Kyoto, Japan. 2016 Oct 11-15. Oral presentation.

3.      Tseng Chiung Ying, Hung Yu Sun, Wei Jen Tsai, Pin Nan Cheng, Yen Cheng, Chiu, Ting Tsung Chang, Kung Chia Young. The impacts of Zepatier or Harvoni treatment on plasma lipid profiles in chronic hepatitis C patients. 23rd International Symposium on Hepatitis C Virus and Related Viruses. Kyoto, Japan. 2016 Oct 11-15.

4.      Wei Jen Tsai, Hung Yu Sun, Tseng Chiung Ying, Pin Nan Cheng, Yen Cheng, Chiu, Ting Tsung Chang, Kung Chia Young. Cultivated cell based evaluation of apolipoproteins with the treatment of direct acting antiviral agents against hepatitis C virus infection. 23rd International Symposium on Hepatitis C Virus and Related Viruses. Kyoto, Japan. 2016 Oct 11-15

5.      Pin-Nan Cheng, Hung-Yu Sun, Chong-Ying Tseng, Wei-Jen Tsai, Yen-Cheng Chiu, Kung-Chia Young. Impacts of Direct-Acting Antiviral Agents on Plasma Lipid Profiles of Chronic Hepatitis C Patients. 5th APASL Single Topic Conference on Hepatitis C,  Kaohsiung, Taiwan (R.O.C), 2016 June 10–12

6.      Hung-Yu Sun, Pei-Ju Tsai, Chiung-Wen Tsao, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids to inhibit hepatitis C virus infection and prevent lipid accumulation. 5th International Symposium on Infectious Disease and Signal Transduction/2015 Tawain-Japan Joint Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan (R.O.C), 2015 Nov 11-15.

7.      Tsao, C.W., Lin, Y.M., Sun, H.Y., Young, K.C., Chien, Y.C., Feng, W.T. Anti-HCV effect of PK11195 via blockade of nitric oxide release. 5th International Symposium on Infectious Disease and Signal Transduction/2015 Tawain-Japan Joint Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan (R.O.C), 2015 Nov 11-15.

8.      Hung-Yu Sun, Pei-Ju Tsai, Chiung-Wen Tsao, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids exerting inhibitions of hepatitis C virus infection and lipid accumulation in hepatocytes. 10th Asia-Pacific Congress of Medical Virology 2015 (APCMV 2015) in conjunction with 12th Taipei International Conference on HIV/AIDS, Taipei, Taiwan (R.O.C), 2015 Oct 15-18.

9.      Hung-Yu Sun, Chun-Chieh Lin, Pei-Ju Tsai, Chiung-Wen Tsao, Chih-Hsing Wu, Ting-Tsung Chang, Kung-Chia Young. Lipoprotein lipase inhibits HCV infection through free fatty acids-mediated PPARa pathway. 21th International Meeting on Hepatitis C Virus and Related Viruses, Banff, Canada, 2014 Sep 7-11.

10.  Peiju Tsai, Chun-Chieh Lin, Hung-Yu Sun, Sung-Fang Chen, Yu-Wei Shiu, Kung-Chia Young. Establishment of Acute and Chronic Hepatitis C Virus Infections in Cell-Based Reporter System. 21th International Meeting on Hepatitis C Virus and Related Viruses, Banff, Canada, 2014 Sep 7-11.

11.  Lin CC, Tsai PJ, Sun HY, Lee JC, Lai MD, Chang TT, Young KC. Apolipoprotein J is an essential host factor for the assembly of infectious hepatitis C virus particles. 20th International Meeting on Hepatitis C Virus and Related Viruses, Melbourne, Australia, 2013 Oct 6-10.




奖励与荣誉

2017  台湾肝病防治学术基金会肝病防治优秀论文奖

2017  成功大学-秀传医疗体系学术合作研究计划 共同主持人

执行计划 ” 诊断治疗及预防在病毒/代谢性/癌化肝脏疾病之转译应用:脂蛋白与载脂蛋白的新技术”

2017  台湾必治妥施贵宝股份有限公司代检合作计划

执行计划 ”C型肝炎病毒定量代检”

2016  成功大学医学检验技术中心

执行代检项目 ” 抗C型肝炎病毒药物检测 ”

执行代检项目 ” C型肝炎病毒NS5A抗药性相关变异株检测 ”

执行代检项目 ” 亚培C型肝炎病毒负荷量检验 ”

2014  国立成功大学医学检验生物技术学系

病毒实验室OHSAS 18000职业安全卫生管理系统认证

2014  国立成功大学医学检验生物技术学系

病毒实验室TOSHMS台湾职业安全卫生管理系统认证

2013  景凯生物科技股份有限公司代检合作计划

执行计划 ”景凯药物检测”

2013  财团法人工业技术研究院代检合作计划