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徐翔晖

发布于:2019-09-25 星期三 11:20:18 点击数:592

徐翔晖 高像素.jpg    徐翔晖

     教授、博士生导师

     

    Email: xianghui.xu@hnu.edu.cn

基本信息

徐翔晖,长期从事精准化生物医用高分子药物与载体的研究工作:发现了树状高分子可控组装与调控规律,实现了低代数树状高分子的高效分子递送;创制了仿病毒高侵染的树状高分子载体系统,为解决肿瘤耐药及渗透提供了新思路;建立了精准化肽类树状高分子药物的研究领域,揭示了树状高分子药物的构效关系。以第一作者或通讯作者在Angewandte Chemie International Edition、Advanced Materials、ACS Nano、Advanced Functional Materials、Materials Horizons、Chemistry of Materials、Small、Theranostics等国际重要期刊发表了一系列研究性论文;申请国家发明专利13 项,已授权7 项。主持国家自然科学基金青年基金、面上项目等多项科研项目;受邀在中国材料大会、中国生物材料会等进行邀请报告十余次;担任中国医药生物技术协会分会、中国药学会药剂学青年学者专家委员会等委员;担任Asian Journal of Pharmaceutical Sciences期刊青年编委,及担任Advanced Materials、Nano Letters等多个国际期刊审稿专家。




招聘信息

课题组拟招聘教学科研岗专任教师1-2名(学校提供事业编制、配套启动经费等),科研助理1名。

课题组每年计划招收博士后1-2名(全年均可入站),并长期招收博士研究生和硕士研究生。

欢迎本科生科研训练和联合培养研究生加入。



教育背景

2009.9-2014.6  四川大学            高分子化学与物理专业     理学博士 

2005.9-2009.6  北京化工大学     生物功能材料专业            工学学士   

工作履历

2019.8-至今      湖南大学          生物学院                                            Professor

2018.7-2019.7  美国威斯康辛大学麦迪逊分校     生物医学工程系        Visiting Professor

2017.7-2018.6  南京工业大学   材料科学与工程学院                           Professor

2015.9-2017.6  四川大学          国家生物医学材料工程技术研究中心   Associate Professor

2014.7-2015.8  四川大学          国家生物医学材料工程技术研究中心   Assistant Professor

学术成果

十篇代表性论文*为通讯作者)

[1] Xiao Zhang, Xianghui Xu,* Yachao Li, Cheng Hu, Zhijun Zhang, Zhongwei Gu.* Virion-Like Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer. Advanced Materials 2018, 30, 1707240. (IF=25.809, Cover Feature)

[2] Yachao Li, Xiao Zhang, Zhijun Zhang, Huayu Wu, Xianghui Xu,* Zhongwei Gu.* Tumor-Adapting and Tumor-Remodeling AuNR@ Dendrimer-Assembly Nanohybrids Overcome Impermeable Multidrug-Resistant Cancer. Materials Horizons 2018, 5, 1047-1057. (IF=14.356, Cover Feature)

[3] Yachao Li, Xianghui Xu,* Xiao Zhang, Yunkun Li, Zhijun Zhang, Zhongwei Gu.* Tumor-Specific Multiple Stimuli-Activated Dendrimeric Nanoassemblies with Metabolic Blockade Surmount Chemotherapy Resistance. ACS Nano 2017. 11, 416–429. (IF=13.903)

[4] Xiao Zhang, Zhijun Zhang, Xianghui Xu,* Yunkun Li, Yachao Li, Yeting Jian, Zhongwei Gu.* Bioinspired Therapeutic Dendrimers as Efficient Peptide Drugs Based on Supramolecular Interactions for Tumor Inhibition. Angewandte Chemie International Edition 2015, 54, 4289-4294. (IF=12.257, Cover Feature)

[5] Zhijun Zhang, Xiao Zhang, Xianghui Xu,* Yunkun Li, Yachao Li, Dan Zhong, Yiyan He, Zhongwei Gu.* Virus-Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor-Specific Infection and Systemic Drug Delivery. Advanced Functional Materials 2015, 25, 5250-5260. (IF=15.621, Cover Feature)

[6] Xianghui Xu, Yeting Jian, Yunkun Li, Xiao Zhang, Zhaoxu Tu, Zhongwei Gu.* Bio-Inspired Supramolecular Hybrid Dendrimers Self-Assembled from Low-Generation Peptide Dendrons for Highly Efficient Gene Delivery and Biological Tracking. ACS Nano 2014, 8, 9255-9264. (IF=13.903)

[7] Xianghui Xu, Hui Yuan, Jing Chang, Bin He,* Zhongwei Gu.* Cooperative Hierarchical Self-Assembly of Peptide Dendrimers and Linear Polypeptides into Nanoarchitectures Mimicking Viral Capsids. Angewandte Chemie International Edition 2012, 51, 3130-3133. (IF=12.257)

[8] Cheng Hu, Xianghui Xu,* Xiao Zhang, Yachao Li, Yunkun Li, Zhongwei Gu.* Bioinspired Design of Stereospecific D-Protein Nanomimics for High-Efficiency Autophagy Induction. Chemistry of Materials 2017, 29, 7658−7662. (IF=10.159, Cover Feature)

[9] Xianghui Xu, Yunkun Li, Haiping Li, Rong Liu, Mingming Sheng, Bin He, Zhongwei Gu.* Smart Nanovehicles Based on pH-Triggered Disassembly of Supramolecular Peptide-Amphiphiles for Efficient Intracellular Drug Delivery. Small 2014, 10, 1133-1140. (IF=10.856, Cover Feature)

[10] Xiao Zhang, Yachao Li, Cheng Hu, Yahui Wu, Dan Zhong, Xianghui Xu,* Zhongwei Gu.* Engineering Anticancer Amphipathic Peptide-Dendronized Compounds for Highly-Efficient Plasma/Organelle Membrane Perturbation and Multidrug Resistance Reversal. ACS Applied Materials & Interfaces 2018, 10 , 30952-30962. (IF=8.456, Cover Feature)