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高兵

发布于:2019-09-13 星期五 14:34:32 点击数:122

教授、博士生导师

gaobing@hnu.edu.cn

基本信息

       高兵,湖南大学化学化工学院教授、博士生导师。课题组研究方向:围绕氟化学、点击化学开发新试剂、新方法,并探索其在功能高分子材料、化学生物学领域的应用。

       课题组长期招聘副教授(编制内)、讲师(编制内)、博士后、科研助理,每年有若干名额招收博士研究生、硕士研究生 (推免或统考均可),随时欢迎联合培养学生、本科生入组。课题组与上海有机所、美国斯克里普斯研究所等研究机构的顶尖科研团队建立了深度合作伙伴关系,为学术交流互访、人才联合培养创造良好条件,诚邀对有机化学、材料化学和化学生物学感兴趣的青年才俊加盟!

教育背景

2009 – 2014    中国科学院上海有机化学研究所,博士学位,导师:胡金波研究员

2005 – 2009    吉林大学、化学学院,学士学位

工作履历

2019. 09 –       湖南大学、化学化工学院,教授、博导

2015 – 2019    美国斯克里普斯研究所(Scripps Research),博士后,导师:K. Barry Sharpless 教授

2014 – 2015    中国科学院上海有机化学研究所,科研助理,导师:胡金波研究员

研究领域

氟化学、点击化学(Click Chemistry)及其在功能材料、化学生物学领域的应用

学术成果

[1]    Gao, B.; Li, S. H.; Wu, P.; Moses J. Sharpless, K. B.* “Sulfur(VI)–Carbon Link Enabled Multidimensional Sulfur(VI) Fluoride Exchange Connections from Thionyl Terafluoride (SOF4) Hub” Angew. Chem. Int. Ed. 2018, 57, 1939-1943.

[2]    Gao, B.; Zhang, L. D.; Zheng, Q. H.; Zhou, F.; Klivansky, L. M.; Lu, J. M.; Liu, Y.; Dong, J. J.; Wu, P.; Sharpless, K. B.* “Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates” Nature Chemistry 2017, 9, 1083-1088.

[3]    Gao, B.; Zhao, Y.; Hu, J.*, “AgF-Mediated Fluorinative Cross-Coupling of Two Olefins: Facile Access to alpha-CF3 Alkenes and beta-CF3 Ketones.” Angew. Chem. Int. Ed. 2015, 54, 638-642.

[4]    Gao, B.; Zhao, Y.; Hu, J.; Hu, J.*, “Difluoromethyl 2-pyridyl sulfone: a versatile carbonyl gem-difluoroolefination reagent.” Org. Chem. Front. 2015, 2, 163-168.

[5]    Gao, B.; Hu, J.; Zhao, Y.; Hu, J.*, “Carbonyl olefination of diaryl ketones with heteroaryl sulfoxides.” Tetrahedron Lett. 2015, 56, 4180-4183.

[6]    Gao, B.; Zhao, Y.; Ni, C.; Hu, J.*, “AgF-Mediated Fluorinative Homocoupling of gem-Difluoroalkenes.” Org. Lett. 2014, 16, 102-105.

[7]    Gao, B.; Zhao, Y.; Hu, M.; Ni, C.; Hu, J.*, “gem-Difluoroolefination of Diaryl Ketones and Enolizable Aldehydes with Difluoromethyl 2-Pyridyl Sulfone: New Insights into the Julia-Kocienski Reaction.” Chem. Eur. J. 2014, 20, 7803-7810.

[8]    Gao, B.; Ni, C.; Hu, J., “Selective Incorporation of Difluoromethylene Moieties into Arenes Assisted by Transition Metals.” Chimia 2014, 68, 414-418.

[9]    Smedley, C. J.; Zheng, Q.; Gao, B.; Li, S.; Molino, A.; Duivenvoorden, H. M.; Parker, B. S.; Wilson, D. J. D.; Sharpless, K. B.; Moses, J. E., Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides. Angew. Chem. Int. Ed. 2019, 58, 4552-4556.

[10] Miao, W.; Zhao, Y.; Ni, C.; Gao, B.; Zhang, W.; Hu, J., Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone. J. Am. Chem. Soc. 2018, 140, 880-883.

[11] Wang, H.; Zhou, F.; Ren, G. R.; Zheng, Q. H.; Chen, H. L.; Gao, B.; Klivansky, L.; Liu, Y.; Wu, B.; Xu, Q. F.; Lu, J. M.; Sharpless, K. B.; Wu, P.* “SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts” Angew. Chem. Int. Ed. 2017, 56, 11203-11208.

[12] Zhu, J.; Ni, C.; Gao, B.; Hu, J.*, “Copper(0)-mediated fluoroalkylation of iodobenzene with 2-bromo-1,1,2,2-tetrafluoroethyl compounds: Investigation on the influence of R substituent on the reactivity of RCF2Cu species.” J. Fluorine Chem. 2015, 171, 139-147.

[13] Hu, J.; Gao, B.; Li, L.; Ni, C.; Hu, J.*, “Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide.” Org. Lett. 2015, 17, 3086-3089.

[14] Zhao, Y.; Ni, C.; Jiang, F.; Gao, B.; Shen, X.; Hu, J.* “Copper-Catalyzed Debenzoylative Monofluoromethylation of Aryl Iodides Assisted by the Removable (2-Pyridyl)sulfonyl Group.” Acs. Catal. 2013, 3, 631-634.

[15] Hu, M.; He, Z.; Gao, B.; Li, L.; Ni, C.; Hu, J.* “Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C-F Bond Cleavage.” J. Am. Chem. Soc. 2013, 135, 17302-17305.

[16] Hu, M.; Gao, B.; Ni, C.; Zhang, L.; Hu, J.* “Nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls with PhSO2CF2H reagent in the presence of in situ generated substoichiometric amount of base.” J. Fluorine Chem. 2013, 155, 52-58.

[17] Zhao, Y.; Gao, B.; Ni, C.; Hu, J.* “Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group.” Org. Lett. 2012, 14, 6080-6083.

[18] Zhao, Y.; Gao, B.; Hu, J.* “From Olefination to Alkylation: In-Situ Halogenation of Julia-Kocienski Intermediates Leading to Formal Nucleophilic Iodo- and Bromodifluoromethylation of Carbonyl Compounds” J. Am. Chem. Soc. 2012, 134, 5790-5793.

[19] Huang, W.; Ni, C.; Zhao, Y.; Gao, B.; Hu, J.* “Nucleophilic difluoromethylation of N,N-acetals with TMSCF2SO2Ph reagent promoted by trifluoroacetic acid: A facile access to alpha-difluoromethylated tertiary amines.” J. Fluorine Chem. 2012, 143, 161-166.


奖励与荣誉

湖南省百人计划(2019,青年项目)