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王祖勇

发布于:2017-09-23 星期六 19:09:13 点击数:3079

副教授,博士生导师,湖南大学“岳麓学者”晨星B岗

研究领域:生物材料制造与应用

电子邮箱:wangzy@hnu.edu.cn; zuyong.nus@gmail.com

诚挚欢迎化学、材料、机械工程及生物医学相关专业背景的本科生、硕士研究生和博士研究生加入!

基本信息

        个人简介:男,1984年1月出生,籍贯江苏盐城,博士(工学)

        学习经历:2006年本科毕业于吉林大学生命科学院,师从房学迅教授;2009年硕士毕业于厦门大学材料学院,师从任磊教授;2013年博士毕业于新加坡国立大学机械工程系,师从生物医用材料与转化研究专家Teoh Swee Hin教授和Thian Eng San副教授、激光制造与应用专家Hong Minghui教授、干细胞与胎儿早期诊断临床医生Chan Kok Yen Jerry副教授。2014-2016年留校从事为期3年的博士后研究工作,2017年1月起全职回国工作。

        主要研究领域:聚焦支架材料技术研究,探索微纳材料支架制备工艺与器件性能和生物功能之间的内在联系。感兴趣的课题方向包括:3D打印与纤维材料、医用支架与人体软组织工程、健康监测柔性器件

        发表第一作者/通讯作者SCI/EI收录论文10篇(Google学术:https://scholar.google.com.hk/citations?user=MmLbKs0AAAAJ&hl=zh-CN),研究成果获国际著名组织工程专家John Jansen博士评论和ScienceDaily®、SingHealth News、YAHOO! News等报道。

        迄今申请中国和国际专利5项,肌腱支架材料和薄膜包装材料获国际PCT专利,部分进入大型动物实验阶段同时获中国、欧洲和美国专利申请

        学生培养:诚挚欢迎校内外优秀本科生进课题组开展SIT、毕业论文等相关研究工作。实验室拟每年招收化学、材料、机械工程及生物医学专业硕士和博士研究生3~4人。

教育背景

2009.8-2013.12        博士        新加坡国立大学        (导师:Teoh Swee Hin, Hong Minghui, Thian Eng San, and Chan Kok Yen Jerry)

2006.9-2009.7          硕士        厦门大学                    (导师:任磊)

2002.9-2006.7          本科        吉林大学                    (导师:房学迅)


工作履历

2017.1-至今            副教授                   湖南大学材料科学与工程学院非金属材料与工程系

2014.2-2017.1        博士后研究员        新加坡国立大学生物医用材料与应用中心

2013.9-2014.2        研究员助理            新加坡国立大学光学科学与工程中心

2012.2-2012.3        访问学者                日本京都工业纤维大学


学术兼职

中国生物材料学会会员,担任Elsevier、RSC、ACS和Bentham Science等集团期刊审稿人,包括Acta Biomaterialia、ACS Applied Materials & Interfaces、Polymer Chemistry、Materials Science & Engineering C、Current Medicinal Chemistry等。


研究领域

围绕实现‘支架材料的可控制备和功能’进行探索,主要研究方向包括:

  • 纤维增材制造复合技术(高分子基复合材料)

  • 医用支架材料与人体软组织工程

  • 健康监测柔性器件

  • 皮肤与肌腱修复支架 (转化研究)


研究概况

研究项目:

  • 湖南省自然科学青年基金,基于机械拉伸的“梯度化”生物可适配性腱骨连接点修复材料的构建及机理研究,2018.1-2020.12 5万 主持

  • 国家自然科学青年基金,基于图案化3D打印纤维的可生物适配性肌腱支架的构建及其性能研究,2018.1-2020.12 25万 主持






学术成果

A) 期刊论文 (#, 共同第一作者; *, 通讯作者)

1.       Z Wang*, WJ Lee, BTH Koh, M Hong, W Wang, PN Lim, J Feng, LS Park, M Kim, ES Thian*. Functional regeneration of tendons xxxxx. Science Advances. Accepted 2018.

2.       Dong Wang, Chris Steffi, Zuyong Wang, Chee Hoe Kong, Poon Nian Lim, Zhilong Shi, Eng San Thian, Wilson Wang. Beta-cyclodextrin modified mesoporous bioactive glass nanoparticles/silk fibroin hybrid nanofibers as an implantable estradiol delivery system for the potential treatment of osteoporosis. Nanoscale. 2018, DOI: 10.1039/C8NR05268A

3.       Chris Steffi, Dong Wang, Chee Hoe Kong, Zuyong Wang, Poon Nian Lim, Zhilong Shi, Eng San Thian, Wilson Wang. Estradiol-loaded poly(ε-caprolactone)/silk fibroin electrospun microfibers decrease osteoclast activity and retain osteoblast function. ACS Applied Materials & Interfaces. 2018, 10(12): 9988–9998

4.       Zuyong Wang*, Rui Zhou, Feng Wen, Rongkai Zhang, Lei Ren, Swee Hin Teoh, Minghui Hong*. Reliable laser fabrication: the quest for responsive biomaterials surface. Journal of Materials Chemistry B. 2018, 00(00): doi:10.1039/C7TB02545A

5.       Poon Nian Lim, Toshiisa Konishi, Zuyong Wang, Jason Feng, Jing Han, Zhijie Yang, Eng San Thian. Enhancing osteoconductivity and biocompatibility of silver-substituted apatite in-vivo through silicon co-substitution. Materials Letters. 2018, 212(00): 90-93

6.       Kaichen Xu#, Zuyong Wang#, Chuan Fu Tan, Ning Kang, Lianwei Chen, Lei Ren, Eng San Thian, Ghim Wei Ho, Rong Ji, Minghui Hong. Uniaxially stretched flexible surface plasmon resonance film for versatile surface enhanced raman scattering diagnostics. ACS Applied Materials & Interfaces. 2017, 9(31): 26341-26349

7.       Zuyong Wang, Feng Wen, Rongkai Zhang, Qinyuan Zhang. Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality. MRS Communications. 2017, 7(3): 348-360 (Invited Paper)

8.       Poon Nian Lim, Zuyong Wang, Dong Wang, Toshiisa Konishi, Eng San Thian. Development in additive printing for musculoskeletal tissue engineering-bone and tendon. Current Opinion in Biomedical Engineering. 2017, 2: 99-104 (New Journal, Invited Paper)

9.       Zuyong Wang, Feng Wen, Poon Nian Lim, Qinyuan Zhang, Toshiisa Konishi, Dong Wang, Swee Hin Teoh, Eng San Thian. Nanomaterial scaffolds to regenerate musculoskeletal tissue: signals from within for neovessel formation. Drug Discovery Today. 2017, 22(9): 1385-1391 (Invited Paper)

10.    Poon Nian Lim, Jason Feng, Zuyong Wang, Mark Chong, Toshiisa Konishi, Lay Geok Tan, Jerry Chan, Eng San Thian. In-vivo evaluation of subcutaneously implanted cell-Loaded apatite microcarriers for osteogenic potency. Journal of Materials Science: Materials in Medicine. 2017, 28(6): 86

11.    Shi Yun Tong#, Zuyong Wang#,*, Poon Nian Lim, Wilson Wang, Eng San Thian*. Uniformly-dispersed nanohydroxapatite-reinforced poly(epsilon-caprolactone) composite films for tendon tissue engineering application. Materials Science and Engineering C: Materials for Biological Applications. 2017, 70(Pt 2): 1149-1155 (Invited Paper)

12.    Poon Nian Lim, Zuyong Wang, Lei Chang, Toshiisa Konishi, Cleo Choong, Bow Ho, Eng San Thian. A multi-material coating containing chemically-modified apatites for combined enhanced bioactivity and reduced infection via a drop-on-demand micro-dispensing technique. Journal of Materials Science: Materials in Medicine. 2017, 28(1): 3

13.    Yang Wu#, Zuyong Wang#, Ying Hsi Jerry Fuh, San Yoke Wong, Wilson Wang, Eng San Thian. Direct E-jet printing of three-dimensional fibrous scaffold for tendon tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2017, 105(3): 616–627

14.    Yang Wu, Zuyong Wang, Jerry Ying His Fuh, Yoke San Wong, Wilson Wang, Eng San Thian. Mechanically-enhanced three-dimensional scaffold with anisotropic morphology for tendon regeneration. Journal of Materials Science: Materials in Medicine. 2016, 27(7): 115 (Covered Paper)

15.    Zuyong Wang, Zheren Du, Jerry Kok Yen Chan, Swee Hin Teoh, Eng San Thian, Minghui Hong. Direct laser microperforation of bioresponsive surface-patterned films with through-hole arrays for vascular tissue-tngineering application. ACS Biomaterials-Science & Engineering. 2015, 1(12): 1239-1249

16.    Zuyong Wang, Swee Hin Teoh, Minghui Hong, Fangfang Luo, Yiling Erin Teo, Jerry Kok Yen Chan, Eng San Thian. Dual-mcrostructured porous, anisotropic film for biomimicking of endothelial basement membrane. ACS Applied Materials & Interfaces. 2015, 7(24): 13445-13456

17.    Qinyuan Zhang, Zuyong Wang, Feng Wen, Lei Ren, Jun Li, Swee Hin Teoh, Eng San Thian. Gelatin-siloxane nanoparticles to deliver nitric oxide for vascular cell regulation: synthesis, cytocompatibility, and cellular responses. Journal of Biomedical Materials Research Part A. 2015, 103(3): 929-938

18.    Youyong Yuan, Zuyong Wang, Pingqiang Cai, Jie Liu, Lun-De Liao, Minghui Hong, Xiaodong Chen, Nitish Thakor, Bin Liu. Conjugated polymer and drug co-encapsulated nanoparticles for chemo- and photo-thermal combination therapy with two-photon regulated fast drug release. Nanoscale. 2015, 7: 3067-3076

19.    Zuyong Wang, Swee Hin Teoh, Nuryanti Binti Johana, Mark Seow Khoon Chong, Erin Yiling Teo, Minghui Hong, Jerry Kok Yen Chan, Eng San Thian. Enhancing mesenchymal stem cell response using uniaxially stretched poly(epsilon-caprolactone) film micropatterns for vascular tissue engineering application. Journal of Materials Chemistry B. 2014, 2: 5898-5909.

20.    Zuyong Wang, Jing Lim, Yeow Siong Ho, Qinyuan Zhang, Mark Seow Khoon Chong, Min Tang, Minhui Hong, Jerry Kok Yen Chan, Swee Hin Teoh, Eng San Thian. Biomimetic three-dimensional anisotropic geometries by uniaxial stretching of poly(epsilon-caprolactone) films: degradation and mesenchymal stem cell responses. Journal of Biomedical Materials Research Part A. 2014, 102A: 2197-2207

21.    Zuyong Wang, Erin Yiling Teo, Mark Seow Khoon Chong, Qinyuan Zhang, Jing Lim, Zhiyong Zhang, Minghui Hong, Eng San Thian, Jerry Kok Yen Chan, Swee Hin Teoh. Biomimetic three-dimensional anisotropic geometries by uniaxial stretch of poly(epsilon-caprolactone) films for mesenchymal stem cell proliferation, alignment, and myogenic differentiation. Tissue Engineering Part C: Methods. 2013, 19(7): 538-549 (Featured Press, Immediate Release News)

22.    Pei Yin, Jūn Wang, Lei Ren, Zuyong Wang, Tianxiao Wang, Dong Wang, Miaomiao Thian, Xinhua Thian. Conjugation of membrane-destabilizing peptide onto gelatin–siloxane nanoparticles for efficient gene expression. Materials Science and Engineering: C. 2010, 30(8): 1260-1265

23.    Dongtao Ge, Dewang Wu, Zuyong Wang, Wei Shi, Ting Wu, Aifeng Zhang, Shimin Hong, Jun Wang, Ye Zhang, Lei Ren. Cellular uptake mechanism of molecular umbrella. Bioconjugate Chemistry. 2009, 20(12): 2311-2316

24.    Zuyong Wang#, Yang Zhao#, Lei Ren, Lihua Jin, Liping Sun, Pei Yin, Yafei Zhang, Qiqing Zhang. Novel gelatin-siloxane nanoparticles decorated by Tat peptide as vectors for gene therapy. Nanotechnology. 2008, 19(44): 445103

 

B) 专利

1.       Eng San Thian*, Zuyong Wang, Yi Min Tan, Bow Ho. A Packaging Material and Method of Preparation Thereof. 9/1/2017, Singapore, 10201610373X (Approved), PCT/SG2017/050605, WO 2018/106191 A1 (Approved)

2.       Eng San Thian*, Zuyong Wang, Wilson Wang, Minghui Hong. Tissue Scaffold Device and Method for Fabricating Thereof. 3/11/2015, Singapore, PCT/SG2015/050431, US Patent 15/526,429, European Patent 15859055.4 (Approved)

3.       Swee Hin Teoh*, Zuyong Wang, Erin Y. Teo, Jerry K.Y. Chan, Mark S.K. Chong, Zhiyong Zhang, Chuen Neng Lee, Minghui Hong. Method to Produce Unique Discontinuous 3D Topolographical Cues on Bioresorbable Polymeric Film via Uni-Axial Stretching Below the Melting Temperature for Cell Alignment, Proliferation and Differentiation in Tissue Engineering Applications. 9/3/2011, US Patent, 61/541,201 (Application)

4.       任磊*, 张亚菲, 印佩, 王祖勇, 王军, 张其清. 基于羧甲基壳聚糖的基因递送载体及其制备方法和应用. 26/12/2008, 福建, CN200810072485.X(申请)

5.       任磊*;赵阳;王祖勇;张其清, 一种用于基因递送的载体及其制备方法和应用, 29/5/2008, 福建, CN200810071151.0(授权)


奖励与荣誉

  • 国家优秀自费留学生奖学金                                   国家留学基金委                           中国                        2013

  • 优秀海报奖(Rapid Fire)                                    9th世界生物材料大会                  中国                        2012

  • KIT iTech交流项目奖学金                                     日本文部科学省JASSO                 日本                        2012

  • 新加坡教育局/国立大学研究奖学金                        新加坡国立大学                           新加坡                    2009-2013