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刘剑波

发布于:2018-02-07 星期三 08:29:31 点击数:14013

刘剑波   博士,副教授,博士生导师  

办公室: 纳米楼附一楼

Email: liujianbo@hnu.edu.cn, liujianbohn@gmail.com  

http://nanobio.hnu.edu.cn

基本信息

刘剑波,男,博士,湖南大学化学化工学院副教授;化学生物传感与计量学国家重点实验室、生物纳米与分子工程湖南省重点实验室成员。2011年获得湖南大学博士学位。2017-2019年在英国布里斯托大学开展博士后研究。获得湖南省杰出青年基金(2021年),湖南大学岳麓学者称号(2017年),湖南大学中国共产党成立100周年优秀党员(2021年)等荣誉。在教学方面,承担《分析化学》、《环境化学》、《数据分析与科研绘图》等本科生与研究生课程。在科研方面,主要开展化学生物学与分析化学方面的研究,主持科研项目十余项,包括国家自然科学基金4项,湖南省自然科学基金3项;参与国家自然科学基金重大项目等。围绕原始细胞的仿生构筑、人工细胞的化学合成以及化学生物分析与生物医学应用开展研究,迄今以通讯作者/第一作者在Nat. Chem., J. Am. Chem. Soc., Angew. Chem., CCS Chem.,Chem. Sci. 等期刊发表学术论文40余篇;署名文章100余篇。授权发明专利5项。相关工作在湖南日报、红网、搜狐、网易,“学习强国”客户端,以及ScienceDaily,EurekAlert等国外媒体进行新闻报道。

教育背景

2006–2011,湖南大学,分析化学,博士 (导师:王柯敏 教授)

2004–2006,湖南大学,生物医学工程,硕士  (导师:王柯敏 教授)

2000–2004,湖南大学,化学(应用化学试点班),学士

工作履历

2014-至今,湖南大学,化学化工学院,副教授

2017-2019,英国布里斯托大学,化学学院,博士后 (合作导师: Stephen Mann FRS)

2011-2014,湖南大学,化学化工学院,助理研究员

学术兼职

中国化学会会员,美国化学会会员,中国生物物理学会会员;

教育部学位论文评审专家;

期刊论文评审专家:作为 Nature Review Chemistry, Nature Communication, Chemical Science, Analytical Chemistry, Small, Chemical Communications, Research on Chemical Intermediates, ACS Applied Materials & Interfaces, RSC Advanced, ACS Biomaterials Science & Engineering, Journal of Nanoparticle Research 等国内外期刊审稿人。

研究领域

化学生物学: 原始细胞仿生构筑以及液液相分离行为研究

                     人工细胞的化学合成以及生物医学应用研究

分析化学:    纳米与分子尺度水平上的化学生物分析


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科研项目

主持项目:

1、国家自然科学基金面上项目,22177032,基于凝集体囊泡人造细胞的硫化氢可控供给及其血管舒张应用研究,2022/01 - 2025/12,主持(在研);

2、国家自然科学基金面上项目,21778016,仿生催化产生一氧化氮的级联酶组装体的构建及其抗血栓应用研究,2018/01-2021/12,主持(在研)

3、国家自然科学基金面上项目,21575037,核酸适配体-DNA纳米凝胶药物载体的构建及其肿瘤靶向治疗研究,2016/01-2019/12,主持(结题)

4、国家自然科学基金青年基金,21205033,量子点可逆团聚荧光纳米探针的构建研究,2013/01-2015/12,主持(结题)

5、湖南省杰出青年基金项目,2021JJ10013,凝集体人造细胞的构建及其一氧化氮产生与血管舒张应用研究,2021/01-2023/12,主持(在研)

6、湖南省自然科学基金面上项目,2020JJ4168,一氧化氮仿生催化组装体的构建及其生物效应研究,2020/01-2022/12,主持(在研)

7、湖南省自然科学基金青年项目,2017JJ3026,基于量子点化学鼻阵列图谱的血清蛋白传感技术研究,2017/01-2019/12,主持(结题)

8、湖南大学优秀青年人才培养计划项目,人工细胞的化学构建与诊疗应用,2021/09-2023/09,主持(在研)

9、化学生物传感与计量学国家重点实验室优秀青年人才培养计划项目,人工细胞的化学构建与应用,2021/09-2023/09,主持(在研)

10、化学生物传感与计量学国家重点实验室交叉学科前沿研究项目,2020/01-2021/01,主持(结题)

11、湖南大学青年教师成长计划资助,中央高校基本科研业务费,2012-018,2012/1-2018/12、主持(结题)

参与项目:

12、湖南省重点研发科技计划项目,2017DK2011,面向早期结直肠癌诊治的小鼠T分期原位模型构建及其功能化探针筛选与靶向诊疗应用研究, 2017/03-2019/12,参与(结题)

13、863计划,诊断试剂关键性原辅材料的研制,2012/04-2016/12,参与(结题)

14、国家自然科学基金重大项目子课题,21190041, 核酸适配体的筛选与分子识别基础研究,2012/04-2016/12,参与(结题)

学术成果

发表学术论文100余篇,其中第一作者与通讯作者文章40余篇。授权发明专利5项。

URL:     http://www.researcherid.com/rid/K-1959-2016

ORCID: https://orcid.org/0000-0001-8282-4078


第一作者与通讯作者文章列表:

2021年

[45] Hui Chen, Li Zhou (co-author), Chunying Li, Xiaoxiao He, Jin Huang, Xiaohai Yang, Hui Shi,* Kemin Wang, Jianbo Liu.* Controlled dimerization of artificial membrane receptors for transmembrane signal transduction. Chemical Science, 2021, 12, 8224-8230. https://doi.org/10.1039/D1SC00718A

[44] Yanwen Zhang, Yufeng Chen, Xiaohai Yang, Xiaoxiao He, Mei Li, Songyang Liu, Kemin Wang, Jianbo Liu*, Stephen Mann.* Giant coacervate vesicles as an integrated approach to cytomimetic modeling. Journal of the American Chemical Society, 2021, 143, 2866−2874. https://doi.org/10.1021/jacs.0c12494 

[43] Qiaoshu Chen, Meiling Jian, Hui Chen, Bing Zhou, Hui Shi, Xiaohai Yang, Kemin Wang, Jianbo Liu.* Design of lipophilic split aptamers as artificial carriers for transmembrane transport of adenosine triphosphate. CCS Chemistry, 2021, 3, 144-153.  https://doi.org/10.31635/ccschem.020.202000591 

[42] Yanwen Zhang, Yu Yao, Songyang Liu, Yufeng Chen, Shaohong Zhou, Kemin Wang, Xiaohai Yang,* Jianbo Liu.* Coacervate microdroplet protocells-mediated gene transfection for nitric oxide production and induction of cell apoptosis. Journal of Materials Chemistry B, 2021, DOI: 10.1039/D1TB01930A

[41] Qiaoshu Chen, Yanwen Zhang, Hui Chen, Jianbo Liu,* Juewen Liu.* Enhancing the sensitivity of DNA and aptamer probes in the Dextran/PEG aqueous two-phase system. Analytical Chemistry,  2021, 93, 8577–8584. https://doi.org/10.1021/acs.analchem.1c01419

[40] Yu Yao#, Yanwen Zhang (co-author)#, Li Li, Yan Huang, Xiaohai Yang, Zhihong Peng,* Kemin Wang, Jianbo Liu.* Photothermally activated coacervate model protocells as signal transducers endow mammalian cells with light sensitivity. Advanced Biology, 2021, 5, 2100695. https://doi.org/10.1002/adbi.202100695.

[39] Chunying Li, Hui Chen, Xiaohai Yang,* Kemin Wang, Jianbo Liu.* An ion transport switch based on light-responsive conformation-dependent G-quadruplex transmembrane channels. Chemical Communications, 2021, 57, 8214-8217. https://doi.org/10.1039/D1CC03273A

[38] Yufeng Chen, Yanwen Zhang, Mei Li, Songyang Liu, Xiaohai Yang, Kemin Wang, Stephen Mann,* Jianbo Liu.* Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation. Chemical Communications, 2021,57, 5438-5441. https://doi.org/10.1039/D1CC01483H

2020年

[37] Songyang Liu, Yanwen Zhang, Mei Li, Li Xiong, Zijian Zhang, Xiaohai Yang, Xiaoxiao He, Kemin Wang, Jianbo Liu,* Stephen Mann.* Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells. Nature Chemistry, 2020, 12, 1165-1173. https://www.nature.com/articles/s41557-020-00585-y

[36Jianbo Liu,* Liangfei Tian, Yan Qiao, Shaohong Zhou, Avinash J. Patil, Kemin Wang, Mei Li,* Stephen Mann.* Hydrogel-immobilized coacervate droplets as modular microreactor assemblies. Angewandte Chemie International Edition, 2020, 59, 6853 – 6859. (Hot paper, Cover Article)

[35] Yanwen Zhang, Songyang Liu, Yu Yao, Yufeng Chen, Shaohong Zhou, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Invasion and defense interactions between enzyme-active liquid coacervate protocells and living cells. Small, 2020, 16, 20020733 (Cover Article).

[34] Yufeng Chen, Min Yuan, Yanwen Zhang, Songyang Liu, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Construction of coacervate-in-coacervate multicompartment protocells for spatial organization of enzymatic reactions. Chemical Science, 2020, 11, 8617–8625.

[33] Chunying Li, Hui Chen, Qiaoshu Chen, Hui Shi,* Xiaohai Yang, Kemin Wang, Jianbo Liu.* Lipophilic G-quadruplex isomers as biomimetic ion channels for conformation- dependent selective transmembrane transport. Analytical Chemistry, 2020, 92, 10169–10176.

[32] Qiaoshu Chen, Yibo Liu, Jianbo Liu,* Juewen Liu.* Liposome boosted peroxidase mimicking nanozymes breaking the pH limit. Chemistry - A European Journal, 2020, 26, 16659-16665 (Hot paper).

[31] Yingben Wu,* Yan Liu (co-author), Huizhi Liu, Biao Liu, Wei Chen, Lijuan Xu, Jianbo Liu.* Ion-mediated self-assembly of Cys-capped quantum dots for fluorescence detection of As(III) in water. Analytical Methods, 2020, 12, 4229–4234.

[30] Yan Huang, Haifeng Li, Xiaoxiao He, Xiaohai Yang, Li Li, Songyang Liu, Zhen Zou, Kemin Wang,* Jianbo Liu.* Near-infrared photothermal release of hydrogen sulfide from nanocomposite hydrogels for anti-inflammation applications. Chinese Chemical Letters, 2020, 31, 787-791.

2019年

[29] Miaomiao Zhuang, Yanwen Zhang, Shaohong Zhou, Yun Zhang, Kemin Wang, Jinfang Nie,* Jianbo Liu.* Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum.  Chemical Communications, 2019, 55, 13880-13883.

[28] Chunying Li, Hui Chen, Li Zhou, Hui Shi, Xiaoxiao He, Xiaohai Yang,* Kemin Wang, Jianbo Liu.* Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport. Chemical Communications, 2019, 55, 12004-12007. (Cover Page)

[27] Haifeng Li,  Yu Yao, Hui Shi, Yanli Lei, Yan Huang, Kemin Wang, Xiaoxiao He,* Jianbo Liu.* Near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability. Journal of Materials Chemistry B, 2019, 7, 5992-5997.

[26] Qiaoshu Chen, Shaohong Zhou, Chunying Li, Qiuping Guo, Xiaohai Yang, Jin Huang, Jianbo Liu,* Kemin Wang.* DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging. Chemical Communications, 2019, 55, 4242-4245. 

2018年及其以前

[25] Li Li, Gui Li, Xiaoxiao He, Xiaohai Yang, Songyang Liu, Jinlu Tang, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Protein- driven disassembly of surfactant- polyelectrolyte nanomicelles: Modulation of quantum dot/fluorochrome FRET for pattern sensing. Sensors and Actuators B: Chemical, 2018, 272, 393-399.

[24] Li Zhou, Yu Liu, Hui Shi, Xiaohai Yang, Jin Huang, Songyang Liu, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.*  Flexible assembly of an enzyme cascade on a DNA triangle prism nanostructure for the controlled biomimetic generation of nitric oxide. ChemBioChem. 2018, 19, 2099-2106. 

[23] Wei Liu, Jue Zhang, Zhihong Peng, Xiaohai Yang, Li Li, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Controlled formation of Ag2S/Ag Janus nanoparticles using alkylamine as reductant surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, 544, 111-117.

[22] Qiaoshu Chen, Chunying Li, Xiaohai Yang, Jin Huang, Songyang Liu, Wei Liu, Jianbo Liu,* Kemin Wang*. Self-assembled DNA nanowires as quantitative dual-drug nanocarriers for antitumor chemophotodynamic combination therapy. Journal of Materials Chemistry B, 2017, 5, 7529-7537.

[21] Yu LiuQiaoshu ChenXiaohai YangQiuping GuoLi Li, Jianbo Liu,* Kemin Wang*. Design of modular DNA triangular-prism sensor enabling ratiometric and multiplexed biomolecule detection on single microbead. Analytical Chemistry2017, 89, 3590−3596.

[20] Xi Guo, Yanwen Zhang, Jianbo Liu,*Xiaohai Yang, Jin Huang, Li Li, Lan Wan, Kemin Wang.* Red blood cell membrane-mediated fusion of hydrophobic quantum dots with living cell membranes for cell imaging. Journal of Materials Chemistry B, 2016, 4, 4191-4197.

[19] Lan Wan, Qiaoshu Chen, Jianbo Liu,* Xiaohai Yang, Jin Huang, Li Li, Xi Guo, Jue Zhang, Kemin Wang* Programmable self-assembly of DNA-protein hybrid hydrogel for enzyme encapsulation with enhanced biological stability. Biomacromolecules, 2016, 17, 1543–1550.

[18] Li Li, Jianbo Liu*, Xiaohai Yang, Jin Huang, Dinggeng He, Xi Guo, Lan Wan, Xiaoxiao He,* Kemin Wang* Biomimetic synthesis of highly biocompatible gold nanoparticles with amino acid-dithiocarbamate as a precursor for SERS imaging. Nanotechnology, 2016, 27, 105603.

[17] Xing Shi, Jue Zhang, Xiaohai Yang, Wei Liu, Li Li, Gui Li, Jianbo Liu,* Kemin Wang* Metallurgical leaching of metal powder for facile and generalized synthesis of metal sulfide nanocrystals. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 497, 344–351

[16] Wei Liu, Xiaohai Yang, Dinggeng He, Leiliang He, Li Li, Yu Liu, Jianbo Liu,* Kemin Wang.* Dopamine modulated ionic permeability in mesoporous silica sphere based biomimetic compartment. Colloids and surfaces B: Biointerfaces, 2016, 142, 266–271.

[15] Jianbo Liu, Haining Ji, Jin Huang, Li Li, Qing Wang, Xiaohai Yang,* Kemin Wang.* Intelligent nucleic acid functionalized dual-responsive gold nanoflare: logic-gate nanodevice visualized by single-nanoparticle imaging. ChemistrySelect, 2016, 1(2), 347 –353

[14] Li Li, Jianbo Liu (co-author), Xiaohai Yang, Zhihong Peng, Wei Liu, Xu Jianguo, Jinglu Tang, Xiaoxiao He,* Kemin Wang.* Quantum dot/ methylene blue FRET mediated NIR fluorescent nanomicelles with large Stocks shift for bioimaging. Chemical Communications, 2015, 51, 14357-14360.

[13] Chunlei Wu, Jianbo Liu (co-author), Pengfei Zhang, Jing Li, Haining Ji, Xiaohai Yang, Kemin Wang* Recognition-before-labeling strategy for sensitive detection of lung cancer cells with quantum dots-aptamer complex. Analyst, 2015,140, 6100-6107.

[12]  Wei Liu, Jianbo Liu  (co-author), Xiaohai Yang, Kemin Wang,* Qing Wang, Meng Yang, Li Li, Chunxia Song. Phosphate modulated permeability of mesoporous silica spheres: a biomimetic ion channel decorated compartment model. Journal of Materials Chemistry B, 2015, 2015,3, 323-329.

[11]  Jianbo Liu, Gui Li, Xiaohai Yang, Kemin Wang,* Li Li, Wei Liu, Xing Shi, Yali Guo. Exciton energy transfer-based quantum dot fluorescence sensing array: “chemical noses” for discrimination of different nucleobases. Analytical Chemistry, 2014, 87, 876-883.

[10]  Jianbo Liu, Pengfei Zhang, Xiaohai Yang, Kemin Wang,* Qiuping Guo, Jin Huang, Wei Li. Aptamer-mediated indirect quantum dot labeling and fluorescent imaging of target proteins in living cells. Nanotechnology, 2014, 25, 505502.

[9]  Jianbo Liu, Xiaohai Yang, Kemin Wang,* Qing Wang, Wei Liu, Dong Wang. Solid-phase single molecule biosensing using dual-color colocalization of fluorescent quantum dot nanoprobes. Nanoscale 2013, 5, 11257-11264.

[8]  Jianbo Liu, Yan Liu, Xiaohai Yang, Kemin Wang,* Qing Wang, Hui Shi, Li Li. Exciton energy transfer-based fluorescent sensing through aptamer-programmed self-assembly of quantum dots. Analytical Chemistry 2013, 85, 11121-11128.

[7]  Jianbo Liu, Xiaohai Yang, Kemin Wang,* Xiaoxiao He, Qing Wang, Jin Huang, Yan Liu. Aggregation control of quantum dots through ion-mediated hydrogen bonding shielding. ACS Nano, 2012, 6, 4973-4983.

[6]  Jianbo Liu, Xiaohai Yang, Kemin Wang,* Qing Wang, Haining Ji, Chunlei Wu, Jing Li, Xiaoxiao He, Jinlu Tang, Jin Huang. Combining physical embedding and covalent bonding for stable encapsulation of quantum dots into agarose hydrogels. Journal of Materials Chemistry, 2012, 22, 495-501.

[5]  Jianbo Liu, Xiaohai Yang, Kemin Wang,* Yan He, Pengfei Zhang, Haining Ji, Lixin Jian, Wei Liu. Single nanoparticle imaging and characterization of different phospholipid-encapsulated quantum dot micelles. Langmuir, 2012, 28, 10602-10609.

[4]  Jianbo Liu, Xiaohai Yang, Kemin Wang,* Ronghua Yang, Haining Ji, Liyan Yang, Chunlei Wu. A switchable fluorescent quantum dot probe based on aggregation/disaggregation mechanism. Chemical Communications, 2011, 47, 935-937.

[3]  Jianbo Liu, Xiaohai Yang, Xiaoxiao He, Kemin Wang,* Qing Wang, Qiuping Guo, Hui Shi, Jin Huang, Xiqin Huo. Fluorescent nanoparticles for chemical and biological sensing. Science China-Chemistry, 2011, 54, 1157-1176.

[2]  Jianbo Liu, Xiaohai Yang, Kemin Wang,* Dong Wang, Pengfei Zhang. Chemical etching with tetrafluoroborate: a facile method for resizing of CdTe nanocrystals under mild conditions. Chemical Communications, 2009, 6080-6082.

[1] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Weihong Tan, Zhaohui Li, Pengfei Zhang, Dong Wang. Preparation of hydrophobic quantum dots using oleylamine-hydrogen selenide complex as precursor. Chemical Journal of Chinese Universities, 2008, 29, 2516-2520.


近五年学术报告:

(1) Jianbo Liu, A new protocell model: coacervate microdroplets via liquid-liquid phase separation, 19th Chinese Biophysics Congress, Hefei, July 23-26, 2021.

(2) Jianbo Liu, Protocells: a new kind of artificial cells, The International Youth Conference of Bionic Science and Engineering Conference 2021 (IYCBSE2021). Shenzhen,  July 17-18 2021

(3) 刘剑波,人造细胞的生物医学应用研究,微纳米技术与医疗健康创新大会(2021), 2021 年5月29-31日

(4) 刘剑波,基于人造细胞的生物分析与疾病诊疗应用研究,中国化学会年会,珠海,2021 年4月17-22日。

(5) Jianbo Liu, NIR photocontrolled H2S release from the thermal degradation of dithiocarbamate based on Au-Ag@Au nanoparticle, 2017 International Congress on Analytical Sciences (2017 ICAS), Haikou, May 5-8, 2017.

(6) 刘剑波,基于DNA 三棱柱的生物分析应用研究,第十三届全国化学传感器学术会议,桂林,2017年11月5-8日。



奖励与荣誉

2021 年 中国十大新锐科技人物;

2021 年 湖南省杰出青年科学基金获得者;

2021 年 湖南大学 庆祝中国共产党100周年 优秀党员;

2018 年 湖南大学优秀硕士论文指导老师;

2017 年 欧盟玛丽居里行动计划Seal of Excellence 奖章;

2017 年 湖南大学岳麓学者晨星A 岗

2012 年 湖南大学优秀博士学位论文。