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刘剑波

发布于:2018-02-07 星期三 08:29:31 点击数:5932

刘剑波   副教授  岳麓学者

办公室: 环境馆南106室

Email: liujianbo@hnu.edu.cn, liujianbohn@gmail.com  

http://nanobio.hnu.edu.cn


基本信息

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教育背景

2006–2011,湖南大学,分析化学,博士 (导师:王柯敏 教授)

2004–2006,湖南大学,生物医学工程,硕士  (导师:王柯敏 教授)

2000–2004,湖南大学,化学(应用化学试点班),学士


工作履历

2014-至今,湖南大学,化学化工学院,副教授

2015-2017,英国布里斯托大学,化学学院,访问博士后 (导师: Stephen Mann FRS)

2011-2014,湖南大学,化学化工学院,助理研究员

研究领域

分析化学: 

纳米与分子尺度水平上的化学生物分析

化学生物学: 

细胞与组织仿生及其生物医学应用研究

科研项目

1、国家自然科学基金面上项目,21778016,仿生催化产生一氧化氮的级联酶组装体的构建及其抗血栓应用研究,2018/01-2021/12,主持;

2、国家自然科学基金面上项目,21575037,核酸适配体-DNA纳米凝胶药物载体的构建及其肿瘤靶向治疗研究,2016/01-2019/12,主持;

3、国家自然科学基金青年基金,21205033,量子点可逆团聚荧光纳米探针的构建研究,2013/01-2015/12,主持;

4、湖南省自然科学基金青年项目,2017JJ3026,基于量子点化学鼻阵列图谱的血清蛋白传感技术研究,2017/01-2019/12,主持;

5、湖南大学青年教师成长计划资助,中央高校基本科研业务费,2012/1-2018/12、主持;

6、湖南省重点研发科技计划项目,2017DK2011,面向早期结直肠癌诊治的小鼠T分期原位模型构建及其功能化探针筛选与靶向诊疗应用研究, 2017/03-2019/12,参与;

7、863计划,诊断试剂关键性原辅材料的研制,2012/04-2016/12,参与;

8、国家自然科学基金重大项目子课题,21190041, 核酸适配体的筛选与分子识别基础研究,2012/04-2016/12,参与。

学术成果

发表学术论文80余篇,其中第一作者与通讯作者文章30余篇。授权发明专利5项。

URL:     http://www.researcherid.com/rid/K-1959-2016

ORCID: https://orcid.org/0000-0001-8282-4078


[32]    Chunying Li, Hui Chen, Qiaoshu Chen, Hui Shi,* Xiaohai Yang, Kemin Wang, and Jianbo Liu.* Lipophilic G-quadruplex isomers as biomimetic ion channels for conformation- dependent selective transmembrane transport. Analytical Chemistry 2020, https://doi.org/10.1021/acs.analchem.0c02222.

[31]     Yanwen Zhang, Songyang Liu, Yu Yao, Yufeng Chen, Shaohong Zhou, Xiaohai Yang, Kemin Wang,* and Jianbo Liu.* Invasion and defense interactions between enzyme-active liquid coacervate protocells and living cells. Small, 2020, https://doi.org/10.1002/smll.202002073.

[30]      Jianbo Liu,* Liangfei Tian, Yan Qiao, Shaohong Zhou, Avinash J. Patil, Kemin Wang, Mei Li,* and Stephen Mann.* Hydrogel-immobilized coacervate droplets as modular microreactor assemblies. Angewandte Chemie International Edition, 2020, 59, 6853 – 6859. (Hot paper, Cover Article)

[29]      Yan Huang, Haifeng Li, Xiaoxiao He, Xiaohai Yang, Li Li, Songyang Liu, Zhen Zou, Kemin Wang,* Jianbo Liu.* Near-infrared photothermal release of hydrogen sulfide from nanocomposite hydrogels for anti-inflammation applications. Chinese Chemical Letters, 2020, 31, 787-791.

[28]      Miaomiao Zhuang, Yanwen Zhang, Shaohong Zhou, Yun Zhang, Kemin Wang, Jinfang Nie* and Jianbo Liu.* Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum.  Chemical Communications, 2019, 55, 13880-13883.

[27]      Chunying Li,  Hui Chen,  Li Zhou,  Hui Shi,  Xiaoxiao He,  Xiaohai Yang,*  Kemin Wang  and  Jianbo Liu.* Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport. Chemical Communications, 2019, 55, 12004-12007. (Cover Page)

[26]     Haifeng Li,  Yu Yao, Hui Shi, Yanli Lei, Yan Huang, Kemin Wang, Xiaoxiao He* and Jianbo Liu.* Near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability. Journal of Materials Chemistry B, 2019, 7, 5992-5997.

[25]      Qiaoshu Chen, Shaohong Zhou, Chunying Li, Qiuping Guo, Xiaohai Yang, Jin Huang, Jianbo Liu* and Kemin Wang* DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging. Chemical Communications, 2019, 55, 4242-4245. 

[24]      Li Li, Gui Li, Xiaoxiao He, Xiaohai Yang, Songyang Liu, Jinlu Tang, Qiaoshu Chen, Jianbo Liu*, Kemin Wang.* Protein- driven disassembly of surfactant- polyelectrolyte nanomicelles: Modulation of quantum dot/fluorochrome FRET for pattern sensing. Sensors and Actuators B: Chemical, 2018, 272, 393-399.

[23]      Li Zhou, Yu Liu, Hui Shi, Xiaohai Yang, Jin Huang, Songyang Liu, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.*  Flexible Assembly of an Enzyme Cascade on a DNA Triangle Prism Nanostructure for the Controlled Biomimetic Generation of Nitric Oxide. ChemBioChem. 2018, 19, 2099-2106. 

[22]      Wei Liu, Jue Zhang, Zhihong Peng, Xiaohai Yang, Li Li, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Controlled formation of Ag2S/Ag Janus nanoparticles using alkylamine as reductant surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, 544, 111-117.

[21]      Qiaoshu Chen, ChunyingLi,  Xiaohai Yang, Jin Huang,  Songyang Liu, Wei Liu,  Jianbo Liu* and  Kemin Wang*. Self-assembled DNA Nanowires as Quantitative Dual-drug Nanocarriers for Antitumor ChemophotodynamicCombination Therapy.    Journal of Materials Chemistry B, 2017,5(36), 7529-7537.

[20]      Yu LiuQiaoshu ChenXiaohai YangQiuping GuoLi Li, Jianbo Liu,* Kemin Wang*. Design of Modular DNA Triangular-Prism Sensor Enabling Ratiometric and Multiplexed Biomolecule Detection on SingleMicrobead. Analytical Chemistry2017, 89(3), 3590−3596.

[19]      Xi Guo, Yanwen Zhang, Jianbo Liu,*Xiaohai Yang, Jin Huang, Li Li, Lan Wan, Kemin Wang*Red Blood Cell Membrane-Mediated Fusion of Hydrophobic Quantum Dots with Living Cell Membranes for Cell Imaging. Journal of Materials Chemistry B, 2016, 4(23), 4191-4197.

[18]      Lan Wan, Qiaoshu Chen, Jianbo Liu,* Xiaohai Yang, Jin Huang, Li Li, Xi Guo, Jue Zhang, Kemin Wang* Programmable Self-Assembly of DNA-Protein Hybrid Hydrogel for Enzyme Encapsulation with Enhanced Biological Stability. Biomacromolecules, 2016, 17 (4), 1543–1550.

[17]      Li Li, Jianbo Liu*, Xiaohai Yang, Jin Huang, Dinggeng He, Xi Guo, Lan Wan, Xiaoxiao He, Kemin Wang* Biomimetic synthesis of highly biocompatible gold nanoparticles with amino acid-dithiocarbamate as a precursor for SERS imaging. Nanotechnology, 2016, 27(10): 105603.

[16]      Xing Shi, Jue Zhang, Xiaohai Yang, Wei Liu, Li Li, Gui Li, Jianbo Liu,*Kemin Wang* Metallurgical leaching of metal powder for facile and generalized synthesis of metal sulfide nanocrystals. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 497, 344–351

[15]      Wei Liu, Xiaohai Yang, Dinggeng He, Leiliang He, Li Li, Yu Liu, Jianbo Liu,*Kemin Wang* Dopamine modulated ionic permeability in mesoporous silica sphere based biomimetic compartment. Colloids and surfaces B: Biointerfaces, 2016, 142, 266–271.

[14]      Jianbo Liu, Haining Ji, Jin Huang, Li Li, Qing Wang, Xiaohai Yang, Kemin Wang* Intelligent Nucleic Acid Functionalized Dual-Responsive Gold Nanoflare: Logic-Gate Nanodevice Visualized by Single-Nanoparticle Imaging. ChemistrySelect, 2016, 1(2), 347 –353

[13]      Li Li, Jianbo Liu (co-author), Xiaohai Yang, Zhihong Peng, Wei Liu, Xu Jianguo, Jinglu Tang, Xiaoxiao He, Kemin Wang: Quantum dot/ methylene blue FRET mediated NIR fluorescent nanomicelles with large Stocks shift for bioimaging. Chemical Communications, 2015, 51(76), 14357-14360.

[12]  Chunlei Wu, Jianbo Liu (co-author), Pengfei Zhang, Jing Li, Haining Ji, Xiaohai Yang, Kemin Wang: Recognition-before-labeling strategy for sensitive detection of lung cancer cells with quantum dots-aptamer complex. Analyst, 2015,140, 6100-6107.

[11]  Wei Liu, Jianbo Liu  (co-author), Xiaohai Yang, Kemin Wang, Qing Wang, Meng Yang, Li Li, Chunxia Song. Phosphate modulated permeability of mesoporous silica spheres: a biomimetic ion channel decorated compartment model. Journal of Materials Chemistry B, 2015, 2015,3, 323-329.

[10]  Jianbo Liu, Gui Li, Xiaohai Yang, Kemin Wang, Li Li, Wei Liu, Xing Shi, Yali Guo: Exciton Energy Transfer-Based Quantum Dot Fluorescence Sensing Array: “Chemical Noses” for Discrimination of Different Nucleobases. Analytical Chemistry, 2014, 87(2), 876-883.

[9]  Jianbo Liu, Pengfei Zhang, Xiaohai Yang, Kemin Wang, Qiuping Guo, Jin Huang, Wei Li. Aptamer-mediated indirect quantum dot labeling and fluorescent imaging of target proteins in living cells. Nanotechnology, 2014, 25, 505502.

[8]  Jianbo Liu, Xiaohai Yang, Kemin Wang, Qing Wang, Wei Liu, Dong Wang. Solid-phase single molecule biosensing using dual-color colocalization of fluorescent quantum dot nanoprobes. Nanoscale 2013, 5, 11257-11264.

[7]  Jianbo Liu, Yan Liu, Xiaohai Yang, Kemin Wang, Qing Wang, Hui Shi, Li Li. Exciton Energy Transfer-Based Fluorescent Sensing through Aptamer-Programmed Self-Assembly of Quantum Dots. Analytical Chemistry 2013, 85, 11121-11128.

[6]  Jianbo Liu, Xiaohai Yang, Kemin Wang, Xiaoxiao He, Qing Wang, Jin Huang, Yan Liu. Aggregation control of quantum dots through ion-mediated hydrogen bonding shielding. ACS Nano, 2012, 6, 4973-4983.

[5]  Jianbo Liu, Xiaohai Yang, Kemin Wang, Qing Wang, Haining Ji, Chunlei Wu, Jing Li, Xiaoxiao He, Jinlu Tang, Jin Huang. Combining physical embedding and covalent bonding for stable encapsulation of quantum dots into agarose hydrogels. Journal of Materials Chemistry, 2012, 22, 495-501.

[4]  Jianbo Liu, Xiaohai Yang, Kemin Wang, Yan He, Pengfei Zhang, Haining Ji, Lixin Jian, Wei Liu. Single nanoparticle imaging and characterization of different phospholipid-encapsulated quantum dot micelles. Langmuir, 2012, 28, 10602-10609.

[3]  Jianbo Liu, Xiaohai Yang, Kemin Wang, Ronghua Yang, Haining Ji, Liyan Yang, Chunlei Wu. A switchable fluorescent quantum dot probe based on aggregation/disaggregation mechanism. Chemical Communications, 2011, 47, 935-937.

[2]  Jianbo Liu, Xiaohai Yang, Xiaoxiao He, Kemin Wang, Qing Wang, Qiuping Guo, Hui Shi, Jin Huang, Xiqin Huo. Fluorescent nanoparticles for chemical and biological sensing. Science China-Chemistry, 2011, 54, 1157-1176.

[1]  Jianbo Liu, Xiaohai Yang, Kemin Wang, Dong Wang, Pengfei Zhang. Chemical etching with tetrafluoroborate: a facile method for resizing of CdTe nanocrystals under mild conditions. Chemical Communications, 2009, 6080-6082.