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刘艳岚

发布于:2018-03-11 星期日 17:37:48  点击数:37091

教授,博士生导师,海外高层次人才计划入选者

Email:ylliu@hnu.edu.cn

团队主页:http://mbl.hnu.edu.cn/

基本信息

刘艳岚,化学生物传感与计量学国家重点实验室,湖南大学化学化工学院,分子科学与生物医学实验室(MBL),教授, 博士生导师,岳麓学者,国家海外高层次人才计划入选者。主要从事多功能成像探针设计及在重大疾病如癌症及心脑血管疾病的活体成像分析及靶向药物传输方面的研究。以第一作者/通讯作者身份发表文章包括Chem. Rev.、Acc. Chem. Res.、PNAS、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Adv. Funct. Mater.等国际权威期刊论文。研究成果被Science Translational Medicine、NanoWerk等专题报道。文章总他引次数9000余次,单篇最高引用2000余次。多篇文章入选“ESI高被引文章”。

 团队每年招收硕士、博士生若干名,长期招聘博士后研究人员及科研助理,诚邀具有化学、材料、生物、或医学学科背景的青年才俊加盟!


教育背景

2008.09-2014.01 中国科学院长春应用化学研究所 理学博士

2004.09-2008.07  黑龙江大学 理学学士


工作履历

2017.09-至今   湖南大学化学化工学院 教授,博士生导师

2014.02-2017.09  哈佛医学院 博士后


学术兼职

Journal of Analysis and Testing  青年编委  2022-至今


研究领域

生命分析化学、分子影像、诊疗一体化设计及纳米生物技术


科研项目

国家海外高层次人才项目,主持

国家自然科学基金面上项目,主持

国家重点研发计划,课题负责人

湖湘高层次人才聚集工程创新人才项目,主持



学术成果

代表性论文:

1.  Xia, Y.; Li, J.; Wang, L.; Luo, X.; Xie, Y.; Liu, Y.* Spatially Confined Intervention of Cellular Senescence by a Lysosomal Metabolism Targeting Molecular Prodrug for Broad-Spectrum Senotherapy. Angew. Chem. Int. Ed. 2022, 61, e202115764.

2.  Lei, P.; Chen, H.; Feng, C.; Yuan, X.; Xiong, Z.; Liu, Y.*; Liao, W.* Noninvasive Visualization of Sub-5 mm Orthotopic Hepatic Tumor via Nanoprobe-Mediated Inverse Contrast Imaging. ACS Nano 2022, 16, 897-909.

3.  Yuan, X.; Wang, L.; Hu, M.; Zhang L.; Chen, H.; Zhang, D.; Xu, L.; Wang, D.; Liu, Y.;* Tan, W.*, Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-adaptive Cancer Chemodynamic Therapy. Angew. Chem. Int. Ed. 2021, 60, 20943-20951.

4.   Zhang, L.; Wang, L.; Yuan, X.; Zhong, M.; Chen, H.; Zhang, D.; Han, X.; Xie, S.; He, L.; Li, Y.; Chen, F.; Liu, Y.;* Tan, W.* Decoding the Complex Free Radical Cascade by a DNA Framework-Based Artificial DNA Encoder. Angew. Chem. Int. Ed. 2021, 60, 2-13 (Hot paper).

5.  Kong, W.; Wang, L.; Zhao, Y.; Chen, H.; Liu, Y.; Han, X.; Yang, Y.; Wang, J.; You, C*, Liu, Y.* Sequential Module Coordination-Driven Programmable Function Switch of Metal-Molecule Nanoframeworks for Cancer Theranostics. Nano Today 2021, 38, 101126.

6.  He, L.; Chen, F; Zhang, D.; Xie, S.; Xu, S.; Wang, Z.; Zhang, L.; Cui, C.; Liu, Y.;* Tan, W.* Transducing Complex Biomolecular Interactions by Temperature-Output Artificial DNA Signaling Networks. J. Am. Chem. Soc. 2020, 142, 14234-14239.

7.  Xuan, W.; Xia, Y.; Li, T.; Wang, L.; Liu, Y.;* Tan, W.* Molecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy. J. Am. Chem. Soc. 2020, 142, 937-944 (ESI高被引论文).

8.  Zhang, D.; Wang, L.; Yuan, X.; Gong, Y.; Liu, H.; Zhang, J.; Zhang, X.; Liu, Y.;* Tan, W.* Naked-Eye Readout of Analyte-Induced NIR Fluorescence Responses by an Initiation-Input-Transduction Nanoplatform. Angew. Chem. Int. Ed. 2020, 59, 695-699.

9. Han, X.; Wang, L.; Li, T.; Zhang, J.; Zhang, D.; Li, J.; Xia, Y.; Liu, Y.*; Tan, W.* Beyond Blocking: Engineering RNAi-Mediated Targeted Immune Checkpoint Nanoblocker Enables T‑Cell-Independent Cancer Treatment. ACS Nano 2020, 14, 12, 17524−17534.

10.   Liu, Y.;* Shi, J.* Antioxidative nanomaterials and biomedical applications. Nano Today 2019, 27, 146-177.

11. Liu, Y.;* Ji, X.; Tong, W.; Askhatova, D.; Yang, T.; Chen, H.; Wang, Y.; Shi, J.* Engineering Multifunctional RNAi Nanomedicine to Concurrently Target Cancer Hallmarks for Combinatorial Therapy. Angew. Chem. Int. Ed. 2018, 57, 1510-1513.

12.  Liu, Y.; Ai, K.; Ji, X.; Askhatova, D.; Du, R.; Lu, L.;* Shi, J.* Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke. J. Am. Chem. Soc. 2017, 139, 856-862 (ESI高被引论文).

13.   Liu, Y.; Gunda, Y.; Zhu, X.; Xu, X.; Wu, J.; Askhatova, D.; Farokhzad, OC.;* Parangi, S.;* Shi, J.* Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc. Natl. Acad. Sci. USA. 2016, 113, 7750-7755.

14.  Liu, Y.; Ai, K.; Lu, L.* Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields. Chem. Rev. 2014, 114, 5057-115 (ESI高被引论文).

15.  Liu, Y.; Ai, K.; Liu, J.; Yuan, Q.; He, Y.; Lu, L.* A high-performance ytterbium-based nanoparticulate contrast agent for in vivo X-ray computed tomography imaging. Angew. Chem. Int. Ed. 2012, 51, 6, 1437-1442 (ESI高被引论文).


奖励与荣誉

爱思唯尔(Elsevier)“中国高被引学者”(化学)

中国科学院院长优秀奖

中国科学院-澳大利亚必和必拓(BHP Billiton)奖

中国科学院百篇优秀博士论文