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聂舟

发布于:2018-01-04 星期四 14:15:55 点击数:24798

教授,博士生导师

Email: niezhou@hnu.edu.cn/niezhou.hnu@gmail.com


基本信息

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湖南大学二级教授,博士生导师。

现为湖南大学研究生院副院长兼学位办主任,第十二届湖南省政协委员,生物大分子化学生物学湖南省重点实验室主任。

主持国家自然科学基基金杰出青年基金、优秀青年基金等项目,入选国内高层次人才计划,荣获中国化学会青年化学奖等奖励。

教育背景

1998-2002  南开大学生命科学学院 理学学士

2002-2007  中国科学院化学研究所 理学博士


工作履历

2019-至今   湖南大学研究生院副院长兼学位办主任

2015-2019  湖南大学化学化工学院 副院长

2011-2012 Purdue University(普渡大学)  博士后

2011-至今  湖南大学化学化工学院 教授 博士生导师

2008-2010 湖南大学化学化工学院 副教授

2007-2008 湖南大学化学化工学院 讲师

学术兼职

2018年10月-至今 中国化学会青年化学工作者委员会委员

2018年6月-至今 中国化学会期刊《分析化学》编委

2015年7月-至今 英国皇家化学会所属学术期刊《RSC Advances》Associate Editor

研究领域

围绕生物医学中关键机制,如表观遗传及细胞信号传导等开展深入探索,主要开展以下两方面研究:

1. 基于功能蛋白质和核酸的生物传感新方法;

2. 化学手段调控细胞行为和命运。

科研项目

国家自然科学基金杰出青年基金、优秀青年基金、面上项目和青年基金项目,湖南省杰出青年基金项目,湖南省重点实验室项目等。

学术成果

自2009年以来作为通讯作者在J. Am. Chem. Soc.Angew. Chem. Int. Ed., Nano Lett., ACS. Nano., Nucleic Acids Res., Chem. Sci., TrAC-Trend. Anal. Chem., Anal. Chem., Small, Chem. Commun., 等SCI收录源刊物上发表SCI论文70余篇(影响因子> 5,60余篇),近五年论文他引2000多次。获国家发明专利授权2项,受邀为Springer出版社撰写英文学术专著2章。

Selected publications:


  1. X.H. Zhu, R. Tang, S.G. Wang, X.Y. Chen, J.J. Hu, C.Y. Lei, Y. Huang, H.H. Wang, Z. Nie*, S.Z. Yao. Protein@inorganic nanodumpling system for high-loading protein delivery with activatable fluorescence and nagnetic resonance bimodal imaging capabilities. ACS Nano, 2020, 14, 2172-2182

  2. X.Y. Luo#, B.B. Xue#, G.F. Feng#, J.H. Zhang, B. Lin, P. Zeng, H.Y. Li, H.B. Yi, X.-L. Zhang, H.Z. Zhu*, Z. Nie*. Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection. J. Am. Chem. Soc., 2019, 141, 5182-5191

  3. G.F. Feng#, X.Y. Luo#, X. Lu, S.Y. Xie, L. Deng, W.Y. Kang, F. He, J.H. Zhang, C.Y. Lei*, B, Lin, Y. Huang, Z. Nie*, S.Z. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment. Angew. Chem. Int. Ed., 2019, 58, 6590-6594. (Very Important Paper, Back Cover)

  4. M. Wang, F. He, H. Li, S.H. Yang, J.H. Zhang, P. Ghosh, H.-H. Wang*, Z. Nie*. A near-infrared light-activated DNA-agonist nanodevice for nongenetically and remotely controlled cellular signaling and behaviors in live animals. Nano Lett., 2019, 19, 2603-2613.

  5. H. Li, M. Wang, T.H. Shi, S.H. Yang, J.H. Zhang, H.-H. Wang*, Z. Nie*. A DNA-mediated chemically induced dimerization (D-CID) nanodevice for nongenetic engineering of receptor to control cell behaviorAngew. Chem. Int. Ed., 2018, 57,10226-10230. (Hot paper)

  6. Y. Li, S.J. Sun, L. Fan, S.F. Hu, Y. Huang, K. Zhang, Z. Nie*, S.Z. Yao. Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis. Angew. Chem. Int. Ed., 2017, 56, 14888-14892.

  7. Z. Nie*, P.F. Wang, C. Tian, C.D. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405.

  8. C.Y. Lei, Y. Huang, Z. Nie*, J. Hu, L.J. Li, G.Y. Lu, Y.T. Han, S.Z. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362. (Hot Paper)

  9. G.F. Feng, C. Luo, H.B. Yi, L. Yuan, B. Lin, X.Y. Luo, X.X. Hu, H.-H. Wang, C.Y. Lei, Z. Nie*, S.Z. Yao. DNA mimics of red fluorescent proteins (RFP) based on G-quadruplex-confined synthetic RFP chromophores. Nucleic Acids Res., 2017, 45, 10380-10392.

  10. W. Li, Y. Li, Z.L. Liu, B. Lin, H.B. Yi, F. Xu, Z. Nie*, S.Z. Yao. Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity. Nucleic Acids Res., 2016, 44, 7373-7384.

  11.  K.Y. He, Y. Li, B.B. Xiang, P. Zhao, Y.F. Hu, Y. Huang, W. Li, Z. Nie*, S.Z. Yao. A universal platform for building molecular logic circuits based on a reconfigurable three-dimensional DNA nanostructure. Chem. Sci., 2015, 6, 3556-3564.

  12. S.F. Hu, J.H. Zhang, R. Tang, J.H. Fan, H.Q. Liu, W.Y. Kang, C.Y. Lei,  Z. Nie*, Y. Huang*, S.Z. Yao. Click-type protein−DNA conjugation for Mn2+ imaging in living cells. Anal. Chem., 2019, 91, 10180-10187.

  13. S. Wang, W. Song, S. Wei, S. Zeng, S. Yang, C. Lei*, Y. Huang, Z. Nie*, S. Yao. Functional titanium carbide MXenes-loaded entropy-driven RNA explorer for long noncoding RNA PCA3 imaging in live cells. Anal. Chem., 2019, 91, 86228629.

  14. S. Wang, S.H. Wei, S.G. Wang, X.H. Zhu, C. Lei*, Y. Huang, Z. Nie*, S.Z. Yao. Chimeric DNA-functionalized titanium carbide MXenes for simultaneous mapping of dual cancer biomarkers in living cells. Anal. Chem., 2019, 91, 1651-1658.

  15. S.J. Sun, Y.N. Liu, J.L. Xia, M. Miao, R. Tang, C.Y. Lei, Y. Huang, Z. Nie*, S.Z. Yao. A semisynthetic fluorescent protein assembly-based FRET probe for real-time profiling of cell membrane protease functions in situ. Chem. Commun., 2019, 55, 2218-2221.

  16. S. Zeng, D. Liu, C.Y. Li, F. Yu, L. Fan, C.Y. Lei, Y. Huang*, Z. Nie*, S.Z. Yao. Cell-surface-anchored ratiometric DNA tweezer for real-time monitoring of extracellular and apoplastic pH. Anal. Chem., 2018, 90, 13459-13466.

  17. J.K. Wang, Y.L. Zhu, C.A. Grimes, Z. Nie*, Q.Y. Cai*. Eu,Sm,Mn-doped CaS nanoparticles with 59.3% upconversion-luminescence quantum yield: enabling ultrasensitive and facile smartphone-based sulfite detectionAnal. Chem., 2018, 90, 8658–8664.

  18. S.F. Hu, X.Y. Chen, C.Y. Lei, R. Tang, W.Y. Kang, H.H. Deng, Y. Huang*, Z. Nie*, S.Z. Yao. Charge designable and tunable GFP as a target pH-responsive carrier for intracellular functional protein delivery and tracing. Chem. Commun., 2018, 54, 7806-7809.

  19. X.H. Zhu, L. Fan, S.G. Wang, C.Y. Lei*, Y. Huang, Z. Nie*, S.Z. Yao. Phospholipid-tailored titanium carbide nanosheets as a novel fluorescent nanoprobe for activity assay and imaging of phospholipase D. Anal. Chem., 2018, 90, 6742-6748.

  20. J. Zhang, M.L. Wang, R. Tang, Y.N. Liu, C.Y. Lei, Y. Huang*, Z. Nie*, S.Z. Yao. Transpeptidation-mediated assembly of tripartite split green fluorescent protein for label-free assay of sortase activity. Anal. Chem., 2018, 90, 3245-3252.

  21. J.K. Wang, N. He, Y.L. Zhu, Z.B. An, P. Chen, C.A. Grimes, Z.Nie*, Q.Y. Cai*. Highly-luminescent Eu,Sm,Mn-doped CaS up/down conversion nano-particles: application to ultra-sensitive latent fingerprint detection and in vivo bioimaging. Chem. Commun., 2018, 54, 591-594.


奖励与荣誉

2016年 中国化学会青年化学奖

2015年 卢嘉锡优秀导师奖



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