发布于:2018-01-04 星期四 14:15:55  点击数:56155




Dr. Zhou Nie is a professor at the College of Chemistry and Chemical Engineering, Hunan University. He obtained bachelor's degree from Nankai University in 2002, and obtained Ph.D. degree from the Institute of Chemistry, Chinese Academy of Science in 2007. Since 2007, He started his career at the State Key Laboratory of Chemo/Biosensing and Chemometrics at Hunan University. From 2011 to 2012, he received his postdoctoral training at Purdue University. His current research is focused on the development of new chemical-biological tools for the detection and regulation of key factors in crucial biological events, such as cellular signal transduction and transcription regulation. Since 2009, He has published 100+ papers as the corresponding author in high-impact journals (IF > 5), including J. Am. Chem. Soc., Angew. Chem. Int. Ed., Science Advances, Nano Lett., ACS Nano, Nucleic Acids Res., Chem. Sci., Anal. Chem. All his SCI papers have been cited >5000 times by research peers (H-index = 46). He was awarded by the National Science Fund for Distinguished Young Scholars in 2017, the "Cheung Kong Scholar" for Young Scholars in 2015, the Ten Thousand Talent Program for Young Top-notch Talent in 2014, the National Science Fund for Excellent Young Scholars in 2012, and Chinese Chemical Society Award for Outstanding Young Chemist in 2015. Now he is an associate editor of “RSC Advances”.





围绕生物医学中关键机制,如表观遗传及细胞信号传导等开展深入探索,主要开展以下两方面研究:1. 基于功能蛋白质和核酸的生物传感新方法;2. 化学手段调控细胞行为和命运。自2009年以来作为通讯作者在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Science Advances, Nano Lett., ACS. Nano., Nucleic Acids Res., Chem. Sci., Anal. Chem. 等国际国内高水平期刊上发表学术论文100多篇,论文他引5000多次。获国家发明专利授权2项,受邀为Springer出版社撰写英文学术专著2章。


1998-2002  南开大学生命科学学院 理学学士

2002-2007  中国科学院化学研究所 理学博士


2019-至今   湖南大学研究生院副院长兼学位办主任

2015-2019  湖南大学化学化工学院 副院长

2011-2012 Purdue University(普渡大学)  博士后

2011-至今  湖南大学化学化工学院 教授 博士生导师

2008-2010 湖南大学化学化工学院 副教授

2007-2008 湖南大学化学化工学院 讲师


2022年5月-至今 中国化学会分子医学专业委员会委员

2021年8月-至今 中国感光学会光化学和光生物专业委员会委员

2018年10月-至今 中国化学会青年化学工作者委员会委员

2018年6月-至今 中国化学会期刊《分析化学》编委

2015年7月-至今 英国皇家化学会期刊《RSC Advances》副主编



1. 基于功能蛋白质和核酸的生物传感新方法;

2. 化学手段调控细胞行为和命运。




  近年来以通讯作者在J. Am. Chem. Soc.(2), Angew. Chem. Int. Ed.(8), Science Advances, Nano Lett., ACS. Nano., Nucleic Acids Res., Chem. Sci., Anal. Chem等国际国内高水平期刊上发表学术论文100多篇,他引5000多次。获国家发明专利授权2项,受邀为Springer出版社撰写英文学术专著2章。

Selected publications:

  1. M. Wang#D.L. Yang#Q. LuL. LiuZ.X. CaiY.R. Wang, H.-H. Wang, P.F. Wang*. Z. Nie*. Spatially reprogramed receptor organization to Switch Cell behavior using a DNA origami-templated aptamer nanoarrayNano Lett.2022, 22, 8445-8454. 

  2. R. Tang#Y.H. Fu#B. Gong, Y.-Y. FangH.-H. Wang, Y. Huang, Z. Nie*. P. Wei*. A chimeric conjugate of antibody and programmable DNA nanoassembly smartly activates T cells for precise cancer cell targeting. Angew. Chem. Int. Ed., 2022, 61, e202205902.

  3. J.H. Zhang#H.Y. Li#B. LinX.Y.  LuoP. YinT. YiB.B. XueX.-L. ZhangH.Z. ZhuZ. Nie*. Development of near-infrared nucleic acid mimics of fluorescent proteins for in vivo imaging of viral RNA with turn-on fluorescence. J. Am. Chem. Soc., 2021, 143, 19317-19329. 

  4. K. Shi, S.Y. Xie, R.Y. Tian, S. Wang, Q. Lu, D.H. Gao, C.Y. Lei, H.Z. Zhu, Z. Nie*.  A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics.Science Advances, 2021, 7, eabc7802. 

  5. H. Li, J. Gao, L. Cao, X. Xie, J.H. Fan, H.D. Wang, H.-H. Wang*, Z. Nie*.  A DNA molecular robot that autonomously walks on the cell membrane to drive cell motility. Angew. Chem. Int. Ed., 2021, 60, 26087-26095. (VIP Paper, Inside back cover). Featured by Nature Nanotechnology, Chemistry WorldAdvanced Science News.

  6. J.H. Zhang, Z.Y. Qiu, J.H. Fan, F. He, W.Y. Kang, S.H. Yang, H.-H. Wang*, J. Huang*,  Z. Nie*. Scan and Unlock: A programmable DNA molecular automaton for cell-selective activation ligand-based signalingAngew. Chem. Int. Ed., 2021, 60, 6733-6743. (Hot Paper)

  7. X.H. Zhu, R. Tang, S.G. Wang, X.Y. Chen, J.J. Hu, C.Y. Lei, Y. Huang, H.H. Wang, Z. Nie*, S.Z. Yao. Protein@inorganic nanodumpling system for high-loading protein delivery with activatable fluorescence and magnetic resonance bimodal imaging capabilities. ACS Nano, 2020, 14, 2172-2182

  8. X.Y. Luo#, B.B. Xue#, G.F. Feng#, J.H. Zhang, B. Lin, P. Zeng, H.Y. Li, H.B. Yi, X.-L. Zhang, H.Z. Zhu*, Z. Nie*. Lighting up the native viral RNA genome with a fluorogenic probe for the live-cell visualization of virus infection. J. Am. Chem. Soc., 2019, 141, 5182-5191

  9. G.F. Feng#, X.Y. Luo#, X. Lu, S.Y. Xie, L. Deng, W.Y. Kang, F. He, J.H. Zhang, C.Y. Lei*, B, Lin, Y. Huang, Z. Nie*, S.Z. Yao. Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment. Angew. Chem. Int. Ed., 2019, 58, 6590-6594. (VIP Paper, Back cover).

  10. M. Wang, F. He, H. Li, S.H. Yang, J.H. Zhang, P. Ghosh, H.-H. Wang*, Z. Nie*. Near-infrared light-activated DNA-agonist nanodevice for nongenetically and remotely controlled cellular signaling and behaviors in live animals. Nano Lett., 2019, 19, 2603-2613. Featured by The ScientistACS PressPacScience Daily, etc.

  11. H. Li, M. Wang, T.H. Shi, S.H. Yang, J.H. Zhang, H.-H. Wang*, Z. Nie*. A DNA-mediated chemically induced dimerization (D-CID) nanodevice for nongenetic receptor engineering to control cell behaviorAngew. Chem. Int. Ed., 2018, 57,10226-10230.  (Hot Paper)

  12. Y. Li, S.J. Sun, L. Fan, S.F. Hu, Y. Huang, K. Zhang, Z. Nie*, S.Z. Yao. Peptide logic circuits based on chemoenzymatic ligation for programmable cell apoptosis. Angew. Chem. Int. Ed., 2017, 56, 14888-14892. 

  13. Z. Nie*, P.F. Wang, C. Tian, C.D. Mao*. Synchronization of two assembly processes to build responsive DNA nanostructures. Angew. Chem. Int. Ed., 2014, 53, 8402-8405.

  14. C.Y. Lei, Y. Huang, Z. Nie*, J. Hu, L.J. Li, G.Y. Lu, Y.T. Han, S.Z. Yao. Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation analysis. Angew. Chem. Int. Ed., 2014, 53, 8358-8362.  (Hot Paper)

  15. G.F. Feng, C. Luo, H.B. Yi, L. Yuan, B. Lin, X.Y. Luo, X.X. Hu, H.-H. Wang, C.Y. Lei, Z. Nie*, S.Z. Yao. DNA mimics of red fluorescent proteins (RFP) based on G-quadruplex-confined synthetic RFP chromophores. Nucleic Acids Res., 2017, 45, 10380-10392.

  16. W. Li, Y. Li, Z.L. Liu, B. Lin, H.B. Yi, F. Xu, Z. Nie*, S.Z. Yao. Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity. Nucleic Acids Res., 2016, 44, 7373-7384.



2021年 湖南省优秀科技工作者

2021年 湖南省优秀研究生导师

2016年 中国化学会青年化学奖

2015年 卢嘉锡优秀导师奖