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袁林

发布于:2018-01-04 星期四 15:01:14  点击数:48100

教授,博士生导师

E-mail: lyuan【@】hnu.edu.cn

Tel: 0731-88821632




基本信息

袁林,湖南大学化学化工学院、化学生物传感与计量学国家重点实验室教授、博士生导师。分别于南华大学和湖南大学获得学士和博士学位,在新加坡国立大学化学系从事博士后研究。2012年至今,历任湖南大学助理教授、副教授、教授。目前已在国际学术期刊上发表论文100余篇,总引用10000余次,h指数为51,其中2012年至今以第一或通讯作者在J. Am. Chem. Soc.9篇)、 Nat. Commun.(1篇)、 Angew. Chem. Int. Ed.9篇)、CCS Chem.(1Chem. Sci.4篇)Anal. Chem.9篇)Adv. Funct. MaterBiomaterials等期刊发表论文70余篇。主要从事小分子荧光探针及应用方向的研究。

招生专业:分析化学(化学与生物传感/博士和硕士生)、有机化学(生物有机化学/博士和硕士生)


热忱欢迎有志从事科研工作的学生报考/保送本课题组博/硕士研究生(2023年有保送生(含直博生1名)招生计划,欢迎感兴趣的同学申请),欢迎博士毕业生到本课题组开展博士后研究(全年可申请)。


实验室成员:

博士后:李伟、钱明

博士生:蒋刚威(2019)、何龙(2019)、吴倩(2020)、秦作佳(2020)杨飞宇(2021)左姗(2021)、沈阳(2022)、雷千(2022)

硕士生:周慧杰(2020)李海燕(2021)、黄静(2021)、谢雨鑫(2021)、李雁华(2022)、赵欣雨(2022)、郑旭东(2022)

已毕业学生:

程  丹(博士,南华大学教授,获2017年国奖和2020年湖南省优秀博士学位论文、湖南省杰青);

任天兵(博士,湖南大学副教授,获2018年国奖、2019年博新计划、2021年湖南省优秀博士学位论文);

李  伟(博士,湖南大学博士后);

袁  婕(博士,河南师范大学教师);

刘  晓(博士,复旦大学博士后);

樊晓鹏(博士,河北大学教师);

张星星(博士,合肥会通新材料股份有限公司)

潘月(硕士)、魏艳芬(硕士,获2016年国奖)、金芳平(硕士,获2015年国奖)、张倩玲(硕士)、吕芸(硕士,获2018年国奖)、文思雨(硕士)、张维(硕士)、王志尧(硕士)、赖焕华(硕士)、向振(硕士,获2019年国奖)、彭蓉(硕士)尹淑璐(硕士)、卢鹏(硕士、获2020年国奖)龚向阳(硕士)、周千惠(硕士)、郑莹新(硕士)、何林辉(硕士)




教育背景

2002.9-2006.7  南华大学化学化工学院,工学学士;

2006.9-2008.8 湖南大学化学化工学院,无;

2008.9-2013.5  湖南大学化学化工学院,理学博士.



工作履历

2012. 6-2015. 9  湖南大学化学化工学院,助理教授

2014. 2-2015. 3  新加坡国立大学化学系,博士后

2015. 10-2017. 1  湖南大学化学化工学院,副教授

2017. 1- 现在     湖南大学化学化工学院,教授


学术兼职

《中国化学快报》编委: 2022-至今

Chemosensors编委: 2021-至今

Chemistry - An Asian Journal Early Career Advisory Board: 2018-至今

《高等学校化学学报》青年执行编委: 2018-至今



研究领域

分子探针及生物成像、有机光功能染料合成及应用

科研项目

国家高层次人才青年项目(2020-2023;180万)

国家自然科学基金面上项目(课题编号22074036;2021-2024;65万)

湖南大学交叉学科前沿项目 (2020-2022;30万)

国家自然科学基金面上项目(批准文号21877029;2019-2022;67.5万)

湖南大学培养项目 (2019-2022;30万)

国家自然科学基金重点项目(子课题)(2018-2022;50万)

湖湘青年英才项目(课题编号2017RS3019;2017-2019;50万)

国家自然科学基金优秀青年基金(课题编号21622504;2017-2019;130

学术成果

全部文章:YUAN, Lin - Web of Science 核心合集http://orcid.org/0000-0002-1015-5319


Selected Publications:  *(Corresponding Author)

34.  L. He, L.-H. He, S. Xu, T.-B. Ren*, X.-X. Zhang, Z.-J. Qin, X.-B. Zhang, L. Yuan*Engineering of Reversible NIR‐II Redox‐Responsive Fluorescent Probes for Imaging of Inflammation In VivoAngew. Chem. Int. Ed. 2022DOI: 10.1002/anie.202211409.

构建可逆NIR-II氧化还原响应荧光探针用于体内炎症成像- X-MOL资讯

33.  J. Yuan, Q. H. Zhou, S. Xu, W. Li, X. X. Zhang, T. B. Ren,  L. Yuan*, X. B. Zhang*Enhancing the Release Efficiency of Molecular Chemotherapeutic Prodrug by Photodynamic Therapy. Angew. Chem. Int. Ed. 202261(33), e202206169. DOI: 10.1002/anie.202206169.

光动力学治疗介导的偶氮前药激活策略- X-MOL资讯

32.  G. Jiang, T.-B. Ren, E. D’Este, M. Xiong, B. Xiong, K. Johnsson, X.-B. Zhang, L. Wang*, L. Yuan*. A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy. Nat. Commun2022, 13, 2264. DOI:10.1038/s41467-022-29547-3.

“珠联璧合”提升探针多个性能用于STED超分辨成像- X-MOL资讯

31. Z. Qin, T.-B. Ren, H. Zhou, X. Zhang, L. He, Z. Li, X.-B. Zhang. L. Yuan*. NIRII-HDs: A Versatile Platform for Developing Activatable NIR-II Fluorogenic Probes for Reliable In Vivo Analyte Sensing. Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202201541.

NIRII-HDs:用于开发激活型NIR-II荧光成像探针的新型荧光染料- X-MOL资讯

30.  K. Li,T.-B. Ren,S. Huan, L. Yuan*; X.-B. Zhang*. Progress and Perspective of Solid-State Organic Fluorophores for Biomedical Applications. J. Am. Chem. Soc. 2021, 143, 21143–21160.

29.  K. Li, S. Xu, M. Xiong, S.-Y. Huan, L. Yuan*; X.-B. Zhang*. Molecular engineering of organic-based agents for in situ bioimaging and phototherapeutics. Chem. Soc. Rev., 2021, 50, 11766.

28. X. Zhang, T. Ren, Q. Zhang, T. Zeng, Z. Li, F. Yang, X.-B. Zhang, and L. Yuan*, Molecular design strategy to alleviate the environmental interference of two-photon fluorescence probes. Cell Reports Physical Science. 2021, 2, 100471.

27.   X. Liu, L.He, X. Gong, Y. Yang, D. Cheng, J. Peng, L. Wang, X.-B. Zhang, and L. Yuan*, Engineering of Reversible Luminescent Probes for Real-Time Intravital Imaging of Liver Injury and Repair (chinesechemsoc.org). CCS Chem, 2021,  3, 904–916


26. D. Cheng; W. Xu; X. Gong; L. Yuan*; X.-B. Zhang*Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury ImagingAcc. Chem. Res. 2021, 54, 403−415       

Abstract Image

 

25. W. Li; L. Wang; S. Yin; H. Lai; L. Yuan*; X. Zhang. Engineering a highly selective probe for ratiometric imaging of H2Sn and revealing its signaling pathway in fatty liver disease. Chemical Science, 2020, 11, 7991-7999 


Graphical abstract: Engineering a highly selective probe for ratiometric imaging of H2Sn and revealing its signaling pathway in fatty liver disease

24. D. Cheng, J. Peng, Y. Lv, D. Su, D. Liu, M. Chen, L. Yuan*, X. Zhang. De Novo Design of Chemical Stability Near-infrared Molecular Probes for High-fidelity Hepatotoxicity Evaluation in VivoJ. Am. Chem. Soc. 2019DOI: 10.1021/jacs.9b01374


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23.  L. Su, T. Ren, J. Dong*, L. Liu, S. Xie, L. Yuan*, Y. Zhou*, SF. Yin. Cu (I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties.  J. Am. Chem. Soc. 2019 141 (6), 2535–2544. 
DOI: 10.1021/jacs.8b12495

Figure


22.  T. Ren, W. Xu, W. Zhang, X. Zhang, Z. Wang, Z. Xiang, L. Yuan*, X. Zhang. A General Method to Increase Stokes Shift by Introducing Alternating Vibronic Structures. J. Am. Chem. Soc. 2018140 (24), 7716–7722. DOI: 10.1021/jacs.8b04404

ja-2018-04404z_0010.gif


21. T. Ren, W. Xu, Q. Zhang, X. Zhang, S. Wen, H. Yi, L. Yuan*, X. Zhang. Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network. Angew. Chem. Int. Ed. 2018,  57(25), 7473-7477. DOI:10.1002/anie.201800293


image.png


20. Y. Lv,  D. Cheng,  D. Su,  M.Chen,  B.-C. Yin, L. Yuan*, X. Zhang. Visualization of Oxidative Injury in the Mouse Kidney by Selective Superoxide Anion Fluorescent Probes. Chem. Sci., 20189, 7606-7613. DOI:10.1039/C8SC03308K



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19. T. Ren, Q. Zhang,  D. Su, X. Zhang,  L. Yuan*, X. Zhang. Detection of Analytes in Mitochondria without Interference from Other Sites Based on an Innovative Ratiometric Fluorophore. Chem Sci2018 9, 5461-5466. DOI:10.1039/C8SC01673A    

image.png


18.  D. Cheng, Y. Pan, L. Wang, Z. Zeng, L. Yuan*, X. Zhang, Y.-T. Chang. Selective visualization of the endogenous peroxynitrite in an inflamed mouse model by a mitochondria-targetable two-photon ratiometric fluorescent probe. J. Am. Chem. Soc. 2017, 139, 285-292. DOI: 10.1021/jacs.6b10508                                              

TOC18.gif


17.  J. Peng*, A. Samanta, X. Zeng, S. Han, L. Wang, D. Su, D. T. B. Loong, N.-Y. Kang, S.-J. Park, A. H. All, W. Jiang, L. Yuan*, X. Liu*, Y.-T. Chang*. Real-time in vivo hepatotoxicity monitoring through chromophore-conjugated upconversion nanoprobes. Angew. Chem. Int. Ed2017, 56, 4165 –4169. DOI:10.1002/anie.201612020

TOC17.jpg

 

16.  D. Cheng, W. Xu, L. Yuan*, X. Zhang. Investigation of Drug-Induced Hepatotoxicity and Its Remediation Pathway with Reaction-Based Fluorescent Probes. Anal. Chem2017, 89, 7693-7700. DOI: 10.1021/acs.analchem.7b01671

TOC16.gif


15.  T. Ren, W. Xu, F. Jin, D. Cheng, L Zhang, L. Yuan*, X. Zhang. Rational Engineering of Bioinspired Anthocyanidin Fluorophores with Excellent Two-Photon Properties for Sensing and Imaging. Anal. Chem2017, 89, 11427-11434. DOI: 10.1021/acs.analchem.7b02538

TOC15.gif

14.  W. Xu, Z. Zeng, J.-H. Jiang*, Y.-T.Chang*, L. Yuan*. Discerning the chemistry in individual organelles with small molecule fluorescent probes. Angew. Chem. Int. Ed201655, 13658-13699. DOI:10.1002/anie.201510721

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13.  L. Wang, L. Yuan*, X. Zeng, J. Peng, Y. Ni, J. C. Er, W. Xu, B. K. Agrawalla, D. Su, B. Kim, Y.-T. Chang*. A multisite-binding switchable fluorescent probe for monitoring mitochondrial ATP level fluctuation in live cells. Angew. Chem. Int. Ed201655, 1773-1776. DOI:10.1002/anie.201510003 (commercial available at https://www.sigmaaldrich.com/catalog/product/mm/sct045?lang=zh&region=CN)

TOC13.jpg


12.  J. Peng, C. L. Teoh, X. Zeng, A. Samanta, L. Wang, W. Xu, D. Su, L. Yuan*, X. Liu, Y.-T. Chang*. Development of a highly selective, sensitive, and fast response upconversion luminescent platform for hydrogen sulfide detection. Adv. Funct. Mater201626, 191-199. DOI:10.1002/adfm.201503715

TOC12.jpg

11. Y. Wei, D. Cheng, T. Ren, Y. Li, Z. Zeng, L. Yuan*. Design of NIR chromenylium–cyanine fluorophore library for “switch-on” and ratiometric detection of bio-active species in vivoAnal. Chem. 2016, 88, 1842−1849. DOI: 10.1021/acs.analchem.5b04169

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10. L. Yuan, L. Wang, K. Bikram, S.-J. Park, H. Zhu, B. Sivaraman, J. Peng, Q. Xu, Y.-T. Chang. Development of targetable two-photon fluorescent probes to image hypochlorous acid in mitochondria and lysosome in live cell and inflamed mouse model. J. Am. Chem.Soc. 2015, 137, 5930−5938.

9. L. Yuan*, F. Jin, Z. Zeng*, C. Liu, S. Luo, J. Wu. Engineering a FRET strategy to achieve a ratiometric two-photon fluorescence response with a large emission shift and its application to fluorescence imaging. Chem Sci20156, 2360-2365.

8. L. Yuan, W. Lin*, H. Chen, S. Zhu, L. He. A unique family of rigid analogues of the GFP chromophore with tunable two-photon action cross-sections for biological imaging. Angew. Chem. Int. Ed201358, 10018–10022.

7. L. Yuan, W. Lin*, L. Tan, K. Zheng, W. Huang. Lighting up carbon monoxide: fluorescent probes for monitoring CO in living cells. Angew. Chem. Int. Ed201352, 1628–1630.

6. L. Yuan, W. Lin*, K. Zheng, L. He, W. Huang, Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging. Chem. Soc. Rev., 201342, 622-661.

5. L. Yuan, W. Lin*, K. Zheng, S. Zhu, FRET-based small-molecule fluorescent probes: rational design and bioimaging applications. Acc. Chem. Res201346, 1462-1473.

4. L. Yuan, W. Lin, H. Chen, Analogs of Changsha near-infrared dyes with large Stokes Shifts for bioimaging. Biomaterials201334, 9566-9571.

3. L. Yuan, W. Lin*, S. Zhao, W. Gao, B. Chen, L. He, S. Zhu, A unique approach to development of near-infrared fluorescent sensors for in vivo imaging. J. Am. Chem.Soc. 2012134, 13510-13523.

2. L. Yuan, W. Lin,* Y. Xie, B. Chen, S. Zhu. Single fluorescent probe responds to H2O2, NO, and H2O2/NO with three different sets of fluorescence Signals. J. Am. Chem. Soc. 2012, 134, 1305-1315.

1. L. Yuan, W. Lin,* Y. Yang, H. Chen. A unique class of near-infrared functional fluorescent dyes with carboxylic-acid-modulated fluorescence ON/OFF switching: rational design, synthesis, optical properties, theoretical calculations, and applications for fluorescence imaging in living animals. J. Am. Chem. Soc. 2012134, 1200-1211.

 


热忱欢迎有志从事科研工作的学生报考/保送本课题组博/硕士研究生,欢迎博士毕业生到本课题组开展博士后研究(全年可申请)。



奖励与荣誉

湖南省科技创新领军人才                    (2021)

湖南省优秀博士论文指导教师             (两次:2020、2021)

国家“万人计划”青年拔尖人才          (2020)

湖湘青年英才                                     (2017)

国家自然科学基金优秀青年基金获得者(2016)