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蒋健晖

发布于:2018-01-18 星期四 19:56:58 点击数:21036

教授,博士生导师



基本信息

蒋健晖,湖南大学化学化工学院教授,博士生导师。曾主持国家杰出青年科学基金项目、国家重大科学仪器研制项目、国家重点研发项目等。

教育背景

1996/09 – 1999/06   湖南大学,理学博士

1993/09 – 1996/06   湖南大学,理学硕士

1989/09 – 1993/06   湖南大学,理学学士

工作履历

2019/05 至今     湖南大学,副校长

2017/11 – 2019/05     湖南大学,校长助理

2011/01 – 2018/07     湖南大学,化学化工学院 院长

2005/07 – 2010/12  湖南大学,化学化工学院 副院长

2004/12 – 2018/12     化学生物传感与计量学国家重点实验室,副主任

2003/05 – 至今     湖南大学,教授

2002/11 – 2003/02   日本关西学院大学,访问教授

    2001/03 – 2003/05   湖南大学,副教授

2000/11 – 2001/12   日本关西学院大学,博士后

1999/07 – 2001/03   湖南大学,讲师


研究领域

    主要研究方向为生物传感和生物成像,主要涉及生物大分子与细胞半合成及生物成像、生物传感技术与芯片等研究。

科研项目

    国家重点研发项目,2019YFA0905800,新一代DNA合成技术,2020/01-2024/12;

    国家自然科学基金重大科研仪器研制项目,21527810,数字滚环扩增生物分析的单分子成像与计数装置研究,2016/01-2020/12


学术成果

近年部分通讯作者论文:

2019: 

1. Feng Liu, Xiao Shi, Xianjun Liu, Fenglin Wang,* Hai-Bo Yi and Jian-Hui Jiang*, Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging. Chemical Science 2019, 10 (40), 9257-9264.

2. Zhan-Ming Ying, Yue-Yan Yuan, Bin Tu, Li-Juan Tang*, Ru-Qin Yu, Jian-Hui Jiang*, A single promoter system co-expressing RNA sensor with fluorescent proteins for quantitative mRNA imaging in living tumor cells. Chemical Science 2019, 10 (18), 4828-4833.

3. Zhi-Mei Huang, Mei-Ya Lin, Chong-Hua Zhang, Zhenkun Wu,* Ru-Qin Yu, and Jian-Hui Jiang*, Recombinant Fusion Streptavidin as a Scaffold for DNA Nanotetrads for Nucleic Acid Delivery and Telomerase Activity Imaging in Living Cells. Analytical Chemistry 2019, 91 (15), 9361-9365.

4. Na Li, Xiu-Yan Wang, Mei-Hao Xiang, Jin-Wen Liu*, Ru-Qin Yu, and Jian-Hui Jiang*, Programmable Self-Assembly of Protein-Scaffolded DNA Nanohydrogels for Tumor-Targeted Imaging and Therapy. Analytical Chemistry 2019, 91 (4), 2610-2614.

5. Mei-Hao Xiang, Hui Huang, Xian-Jun Liu, Zong-Xuan Tong, Chun-Xia Zhang, Fenglin Wang*, Ru-Qin Yu, and Jian-Hui Jiang*, Mitochondrion-Targeting Fluorescence Probe via Reduction Induced Charge Transfer for Fast Methionine Sulfoxide Reductases Imaging. Analytical Chemistry 2019, 91 (9), 5489-5493.

6. Du-Juan Huang, Ting Cao, Zhi-Mei Huang, Zhenkun Wu, * Li-Juan Tang and Jian-Hui Jiang*, Crosslinking catalytic hairpin assembly for high-contrast imaging of multiple mRNAs in living cells. Chemical Communications 2019, 55 (27), 3899-3902.

7. Na Li, Lan Liu, Mei-Hao Xiang, Jin-Wen Liu*, Ru-Qin Yu, and Jian-Hui Jiang*, Proximity- induced hybridization chain assembly with small- molecule linked DNA for single- step amplified detection of antibodies. Chemical Communications 2019, 55 (30), 4387-4390.

8. Xueli Zhu, Meng-Mei Lv, Jin-Wen Liu*, Ru-Qin Yu, Jian-Hui Jiang*, DNAzyme activated protein-scaffolded CRISPR-Cas9 nanoassembly for genome editing. Chemical Communications 2019, 55 (46), 6511-6514.


2018: 

1. Shuaijun Pan*, Rui Guo, Mattias Björnmalm, Joseph J. Richardson, Ling Li, Chang Peng, Nadja Bertleff-Zieschang, Weijian Xu*, Jianhui Jiang*, Frank Caruso*, Coatings superrepellent to sub-20 mN m−1 liquids, Nature Materials, 2018, 90, 1040-1047.

2. Du-Juan Huang, Zhi-Mei Huang, Hu-Yan Xiao, Zhen-Kun Wu*, Li-Juan Tang, Jian-Hui Jiang*, Protein Scaffolded DNA Tetrads Enable Efficient Delivery and Ultrasensitive Imaging of miRNA through Crosslinking Hybridization Chain Reaction, Chemical Sciences, 2018, 9, 4892-4897.

3. Lan Liu, Jin-Wen Liu, Han Wu, Xiang-Nan Wang, Ru-Qin Yu*, Jian-Hui Jiang*, Branched Hybridization Chain Reaction (bHCR) Circuit for Ultrasensitive Localizable Imaging of mRNA in Living Cells, Analytical Chemistry, 2018, 90, 1502-1505.

4. Jin-Wen Liu, Yu-Min Wang, Chong-Hua Zhang, Lu-Ying Duan, Zheng Li*, Ru-Qin Yu, Jian-Hui Jiang*, Tumor-Targeted Graphitic Carbon Nitride Nanoassembly for Activatable Two-Photon Fluorescence Imaging, Analytical Chemistry, 2018, 90, 4649-4656.

5. Zhan-Ming Ying, Bin Tu, Lan Liu, Hao Tang*, Li-Juan Tang, Jian-Hui Jiang*, Spinach-Based Fluorescent Light-up Biosensors for Multiplexed and label-Free Detection of microRNAs, Chemical Communications, 2018, 54, 3010-3013.

6. Xianjun Liu, Meihao Xiang, Zongxuan Tong, Fenglin Wang*, Ru-Qin Yu and Jian-Hui Jiang*, Activatable Fluorescence Probe via Self-immolative Intramolecular cyclization for Histone Deacetylase Imaging in Live Cells and Tissues, Analytical Chemistry, 2018, 90, 5534-5539.

7. Lan Liu, Jin-Wen Liu, Zhi-Mei Huang, Han Wu, Na Li, Li-Juan Tang* and Jian-Hui Jiang*, Proton-Fueled, Reversible DNA Hybridization Chain Assembly for pH Sensing and Imaging, Analytical Chemistry, 2018, 90, 6944-6947.

8. Wen Chen, Cai Gao, Xianjun Liu, Feng Liu, Fenglin Wang*, Li-Juan Tang, and Jian-Hui Jiang*, Engineering Organelle-Specific Molecular Viscosimeters Using Aggregation-Induced Emission Luminogens for Live Cell Imaging, Analytical Chemistry, 2018, 90, 8736-8741.

9. Na LiMei-Hao XiangJin-Wen Liu*Hao TangJian-Hui Jiang*, DNA Polymer Nanoparticles Programmed Via Supersandwich Hybridization for Imaging and Therapy of Cancer Cells. Analytical Chemistry, 2018, 90, 12951-12958.

10. Xueli ZhuHongyan YeJin-Wen Liu*Ru-Qin YuJian-Hui Jiang*, Multivalent Self-Assembled DNA Polymer for Tumor-Targeted Delivery and Live Cell Imaging of Telomerase Activity. Analytical Chemistry, 2018, 90, 13188-13192.

11. Lu-Ying DuanYu-Jie Wang, Jin-Wen Liu*Yu-Min WangNa LiJian-Hui Jiang*, Tumor-Selective Catalytic Nanosystem for Activatable Theranostics. Chemical Communications, 2018, 54, 8214-8217.

12. Jun-Jie Li, Wan-Ning Li, Wen-Fang Du, Meng-Mei Lv, Zhen-Kun Wu* and Jian-Hui Jiang*, Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing, Chemical Communications, 2018, 54, 10626-10629.

13. Zhan-Ming Ying, Hu-Yan Xiao, Hao Tang*, Ru-Qin Yu and Jian-Hui Jiang*, Light-up RNA aptamer enabled label-free protein detection via a proximity induced transcription assay, Chemical Communications, 2018, 54, 8877-8880.

14. Jiyun Chen, Xiaomin Xu, Zhimei Huang, Yuan Luo, Lijuan Tang*, Jian-Hui Jiang*, BEAMing LAMP: Single-Molecule Capture and On-bead Isothermal Amplification for Digital Detection of Hepatitis C Virus in Plasma, Chemical Communications, 2018, 54, 291-294.

15. Hang Zhang, Guanhua Zhang*, Zhiqin Li, Ke Qu, Huimin Shi, Qingfeng Zhang, Huigao Duan, and Jianhui Jiang*, Osiers-sprout-like heteroatoms doped carbon nanofibers as ultra-stable anodes for lithium/sodium ion storage, Nano Research, 2018, 11(7), 3791-3801.

 

2017: 

1. Zhan-ming Ying, Zhan Wu, Bin Tu, Weihong Tan, Jian-Hui Jiang*, Genetically-encoded Fluorescent RNA Sensor for Ratiometric Imaging of MicroRNA in Living Tumor Cells, Journal of the American Chemical Society, 2017, 139, 9779-9782. 

2. Zhenkun Wu, Huanhuan Fan, Nitya Sai Reddy Satyavolu, WenJing Wang, Ryan Lake, Jian-Hui Jiang,* and Yi Lu*, Imaging Endogenous Metal Ions in Living Cells Using a DNAzyme–Catalytic Hairpin Assembly Probe, Angewandte Chemie International Edition, 2017, 56, 8721-8725. 

3. Ying Tang, Xiao-Li Zhang, Li-Juan Tang, Ru-Qin Yu, Jian-Hui Jiang*, In Situ Imaging of Individual mRNA Mutation in Single Cells Using Ligation Mediated Branched Hybrization Chain Reaction (Ligation-bHCR), Analytical Chemistry, 2017, 89, 3445-3451. 

4. Lan Liu, Jin-Wen Liu, Zhi-Mei Huang, Han Wu, Na Li, Li-Juan Tang*, and Jian-Hui Jiang*, Proton-Fueled, Reversible DNA Hybridization Chain Assembly for pH Sensing and Imaging, Analytical Chemistry, 2017, 89, 6944-6947. 

5. Xueli Zhu, Jin Huang, Jinwen Liu, Hang Zhang, Jianhui Jiang*, Ruqin Yu*, Dual enzyme-inorganic hybrid nanoflowers incorporated microfluidic paper-based analytic devices (µPADs) biosensor for sensitive visualized detection of glucose, Nanoscale, 2017, 9, 5658-5663. 

6. Yu-Min Wang, Jin-Wen Liu, Gary Brent Adkins, Wen Shen, Michael Trinh, Lu-Ying Duan, Jian-Hui Jiang*, Wenwan Zhong*, Enhancement of the Intrinsic Peroxidase-Like Activity of Graphitic Carbon Nitride Nanosheets by ssDNAs and Its Application for Detection of Exosomes, Analytical Chemistry, 2017, 89, 12327-12333. 

7. Feng Liu, Hai-Juan Liu, Xian-Jun Liu, Wen Chen, Feng-Lin Wang*, Ru-Qin Yu, and Jian-Hui Jiang*, Mitochonrion-Targeting, Environment-Sensitive Red Fluorescent Probe for Highly Sensitive Detection and Imaging of Vicinal Dithiol-Containing Proteins, Analytical Chemistry, 2017, 89, 11203-11207.

 

2016: 

1. Xiang-Cheng Lin, Ting Zhang, Lan Liu, Hao Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Mass Spectrometry Based Ultrasensitive DNA Methylation Profiling Using Target Fragmentation Assay, Analytical Chemistry, 2016, 88, 1083-1087. 

2. Jin-Wen Liu, Yu-Min Wang, Liu Xu, Lu-Ying Duan, Hao Tang*, Ru-Qin Yu, and Jian-Hui Jiang*, Melanin-like Nanoquencheron Graphitic Carbon Nitride Nanosheetsfor Tyrosinase Activity and Inhibitor Assay, Analytical Chemistry, 2016, 88, 8355-8358    

3. Chong-Hua Zhang, Ling-Wei Liu, Ping Liang, Li-Juan Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Plasmon Coupling Enhanced Raman Scattering Nanobeacon for Single-Step, Ultrasensitive Detection of Cholera Toxin, Analytical Chemistry, 2016, 88, 7447-7452. 

4. Wei Liu, Si-Jia Liu, Yong-Qing Kuang*, Feng-Yan Luo, Jian-Hui Jiang*, Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells, Analytical Chemistry, 2016, 88, 7867-7872. 

5. Xiang-Cheng Lin, Xiang-Nan Wang, Lan Liu, Qian Wen*, Ru-Qin Yu, Jian-Hui Jiang*, Surface Enhanced Laser Desorption Ionization of Phospholipids on Gold Nanoparticles for Mass Spectrometric Immunoassay, Analytical Chemistry, 2016, 88, 9881-9884. 

6. Ying Tang, Zhan Wu*, Chong-Hua Zhang, Xiao-Li Zhang and Jian-Hui Jiang*, Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors, Chemical Communications, 2016, 52, 3631-3634. 

7. Wenfang Du, Mengmei Lv, Junjie Li, Ruqin Yu*, Jianhui Jiang,* A Ligation-Based Loop-Mediated Isothermal Amplification (Ligation-LAMP) Strategy for Highly Selective MicroRNA Detection, Chemical Communications, 2016, 52, 12721-12724 

8. Chonghua Zhang, Ying Tang, Ying-Ying Sheng, Hui Wang, Zhan Wu*, Jianhui Jiang,* Ultrasensitive Detection of MicroRNAs using Catalytic Hairpin Assembly Coupled with Enzymatic Repairing Amplification, Chemical Communications, 2016, 52, 13584-13587. 

9. Wang Xu, Zebing Zeng, Jian-Hui Jiang,* Young-Tae Chang,* Lin Yuan*, Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes, Angewandte Chemie International Edition, 2016, 55, 13658-13699. 

10. Mei-Hao Xiang, Jin-Wen Liu, Na Li, Hao Tang*, Ru-Qin Yu and Jian-Hui Jiang*, Fluorescent Graphitic Carbon Nitride Nanosheet Biosensor for Highly Sensitive, Label-Free Detection of Alkaline Phosphatase, Nanoscale, 2016, 8, 4727-4732. 

11. Jin-Wen Liu, Ying Luo, Yu-Min Wang, Lu-Ying Duan, Jian-Hui Jiang*, and Ru-Qin Yu*, Graphitic Carbon Nitride Nanosheets-based Ratiometric Fluorescent Probe for Highly Sensitive Detection of H2O2 and Glucose, ACS Applied Materials & Interfaces, 2016, 8, 33439-33445.

 

2015: 

1. Zhan Wu, Gao-Qin Liu, Xiao-Li Yang, Jian-Hui Jiang*, Electrostatic Nucleic Acid Nanoassembly Enables Hybridization Chain Reaction in Living Cells for Ultrasensitive mRNA Imaging, Journal of the American Chemical Society, 2015, 137, 6829-6836. 

2. Zhen-Kun Wu, Dian-Ming Zhou, Zhan Wu*, Xia Chu, Ru-Qin Yu and Jian-Hui Jiang*, Single-Base Mismatch Discrimination by T7 Exonuclease with Target Cyclic Amplification Detection, Chemical Communications, 2015, 51, 2954-2956.

3. Qing Li, Yan-Dan Wang, Guo-Li Shen, Hao Tang*, Ru-Qin Yu, Jian-Hui Jiang*, Split Aptamer Mediated Endonuclease Amplification for Small-Molecule Detection, Chemical Communications, 2015, 51, 4196-4199. 

4. Jian Chen*, Weibang Zhong, Ying Tang, Zhan Wu, Ya Li, Pinggui Yi*, Jianhui Jiang*, Amphiphilic BODIPY-Based Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Patterning and Dual-Color Cell Imaging, Macromolecules, 2015, 48, 3500-3508.

 

2014: 

1. Liping Qiu, Tao Zhang, Jianhui Jiang*, Cuichen Wu, Guizhi Zhu, Mingxu You, Xigao Chen, Liqin Zhang, Cheng Cui, Ruqin Yu, Weihong Tan*, Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment, Journal of the American Chemical Society, 2014, 136, 13090-13093.

2. Dian-Ming Zhou, Wen-Fang Du, Qiang Xi, and Jian-Hui Jiang*, A Novel Isothermal Nucleic Acid Amplification Strategy by Cyclic Enzymatic Repairing for Highly Sensitive MicroRNA Detection, Analytical Chemistry, 2014, 86, 6763-6767.

 3. Qiang Xi, Dianming Zhou, Jin-Wen Liu, Ru-Qin Yu*, Jian-Hui Jiang*, Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification, Analytical Chemistry, 2014, 86, 1361-1365. 

4. Qing Li, Lin Liu, Jin-Wen Liu, Jian-Hui Jiang*, Ru-Qin Yu, Xia Chu*, Nanomaterial-based fluorescent probes for live-cell imaging, Trends in Analytical Chemistry, 2014, 58, 130-144. 

5. Xin-Min Nie, Rong Huang, Cai-Xia Dong, Li-Juan Tang, Rong Gui*, Jian-Hui Jiang*, Plasmonic ELISA for the ultrasensitive detection of Treponema pallidum, Biosensors and Bioelectronics, 2014, 58, 314-319. 

6. Qian Wen, Si-Jia Liu, Li-Juan Tang*, Ying Tang, Jian-Hui Jiang*, Gold Nanoparticle Supported Phospholipid Membranes as A Biomimetic Biosensor Platform for Phosphoinositide Signaling Detection, Biosensors and Bioelectronics, 2014, 62, 113-119.


奖励与荣誉

2014 国家自然科学二等奖

2003 国家自然科学二等奖